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Effects of Electromagnetic Radiation Exposure on Stress-Related Behaviors and Stress Hormones in Male Wistar Rats

Mahdavi SM, Sahraei H, Yaghmaei P, Tavakoli H

  • Biomol Ther.
  • 2014 Nov;22(6):570-576.
  • doi: 10.4062/biomolther.2014.054
Studies have demonstrated that electromagnetic waves, as the one of the most important physical factors, may alter cognitive and non-cognitive behaviors, depending on the frequency and energy. Moreover, non-ionizing radiation...
Evaluation of Osseointegration around Tibial Implants in Rats by Ibandronate-Treated Nanotubular Ti-32Nb-5Zr Alloy

Nepal M, Li L, Bae TS, Kim BI, Soh Y

  • Biomol Ther.
  • 2014 Nov;22(6):563-569.
  • doi: 10.4062/biomolther.2014.111
Materials with differing surfaces have been developed for clinical implant therapy in dentistry and orthopedics. This study was designed to evaluate bone response to titanium alloy containing Ti-32Nb-5Zr with nanostructure,...
Dependence Potential of Tramadol: Behavioral Pharmacology in Rodents

Cha HJ, Song MJ, Lee KW, Kim EJ, Kim YH, Lee Y, Seong WK, Hong SI, Jang CG, Yoo HS, Jeong HS

  • Biomol Ther.
  • 2014 Nov;22(6):558-562.
  • doi: 10.4062/biomolther.2014.064
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance...
Protective Effects of Verapamil against H2O2-Induced Apoptosis in Human Lens Epithelial Cells

Wang Z, Wang D, Li Y, Zhang X

  • Biomol Ther.
  • 2014 Nov;22(6):553-557.
  • doi: 10.4062/biomolther.2014.033
Verapamil is used in the treatment of hypertension, angina pectoris, and atrial fibrillation. Recently, several studies have demonstrated that verapamil increased the optic nerve head blood flow and improved the...
Ribes fasciculatum var. chinense Attenuated Allergic Inflammation In Vivo and In Vitro

Jung JW, Kim SJ, Ahn EM, Oh SR, Lee HJ, Jeong JA, Lee JY

  • Biomol Ther.
  • 2014 Nov;22(6):547-552.
  • doi: 10.4062/biomolther.2014.015
Ribes fasciculatum var. chinense MAX. (R. fasciculatum) has traditionally been used in Korea to treat inflammatory diseases. However, the exact mechanism that accounts for the anti-inflammatory effect of R. fasciculatum...
Novel Suppressive Effects of Ketotifen on Migration and Invasion of MDA-MB-231 and HT-1080 Cancer Cells

Kim HJ, Park MK, Kim SY, Lee CH

  • Biomol Ther.
  • 2014 Nov;22(6):540-546.
  • doi: 10.4062/biomolther.2014.081
The high mortality rates associated with cancer reflect the metastatic spread of tumor cells from the site of their origin. Metastasis, in fact, is the cause of 90% of cancer...
The Protective Effects of IGF-1 on Different Subpopulations of DRG Neurons with Neurotoxicity Induced by gp120 and Dideoxycytidine In Vitro

Lu L, Dong H, Liu G, Yuan B, Li Y, Liu H

  • Biomol Ther.
  • 2014 Nov;22(6):532-539.
  • doi: 10.4062/biomolther.2014.036
Peripheral neuropathy induced by human immunodeficiency virus (HIV) infection and antiretroviral therapy is not only difficult to distinguish in clinical practice, but also difficult to relieve the pain symptoms by...
Apigenin Inhibits Tumor Necrosis Factor-alpha-Induced Production and Gene Expression of Mucin through Regulating Nuclear Factor-Kappa B Signaling Pathway in Airway Epithelial Cells

Seo HS, Sikder MA, Lee HJ, Ryu J, Lee CJ

  • Biomol Ther.
  • 2014 Nov;22(6):525-531.
  • doi: 10.4062/biomolther.2014.094
In the present study, we investigated whether apigenin significantly affects tumor necrosis factor-alpha (TNF-alpha)-induced production and gene expression of MUC5AC mucin in airway epithelial cells. Confluent NCI-H292 cells were pretreated...
Role of Annexin A5 on Mitochondria-Dependent Apoptosis Induced by Tetramethoxystilbene in Human Breast Cancer Cells

Hong M, Park N, Chun YJ

  • Biomol Ther.
  • 2014 Nov;22(6):519-524.
  • doi: 10.4062/biomolther.2014.112
We have previously shown that 2,4,3',5'-tetramethoxystilbene (TMS), a trans-stilbene analogue, induces apoptosis in human cancer cells. However, the detailed mechanisms of mitochondria-dependent apoptosis induced by TMS are not fully understood....
Arsenite Acutely Decreases Nitric Oxide Production via the ROS-Protein Phosphatase 1-Endothelial Nitric Oxide Synthase-Thr497 Signaling Cascade

Seo J, Lee JY, Sung MS, Byun CJ, Cho DH, Lee HJ, Park JH, Cho HS, Cho SJ, Jo I

  • Biomol Ther.
  • 2014 Nov;22(6):510-518.
  • doi: 10.4062/biomolther.2014.106
Chronic (>24 h) exposure of arsenite, an environmental toxicant, has shown the decreased nitric oxide (NO) production in endothelial cells (EC) by decreasing endothelial NO synthase (eNOS) expression and/or its...
Paraquat Induces Apoptosis through Cytochrome C Release and ERK Activation

Seo HJ, Choi SJ, Lee JH

  • Biomol Ther.
  • 2014 Nov;22(6):503-509.
  • doi: 10.4062/biomolther.2014.115
Paraquat has been suggested to induce apoptosis by generation of reactive oxygen species (ROS). However, little is known about the mechanism of paraquat-induced apoptosis. Here, we demonstrate that extracellular signal-regulated...
Arctigenin Increases Hemeoxygenase-1 Gene Expression by Modulating PI3K/AKT Signaling Pathway in Rat Primary Astrocytes

Jeong YH, Park JS, Kim DH, Kim HS

  • Biomol Ther.
  • 2014 Nov;22(6):497-502.
  • doi: 10.4062/biomolther.2014.121
In the present study, we found that the natural compound arctigenin inhibited hydrogen peroxide-induced reactive oxygen species (ROS) production in rat primary astrocytes. Since hemeoxygenase-1 (HO-1) plays a critical role...
Lightening up Light Therapy: Activation of Retrograde Signaling Pathway by Photobiomodulation

Kim HP

  • Biomol Ther.
  • 2014 Nov;22(6):491-496.
  • doi: 10.4062/biomolther.2014.083
Photobiomodulation utilizes monochromatic (or quasimonochromatic) light in the electromagnetic region of 600~1000 nm for the treatment of soft tissues in a nondestructive and nonthermal mode. It is conceivable that photobiomodulation...
Non-Thermal Atmospheric-Pressure Plasma Possible Application in Wound Healing

Haertel B, von Woedtke T, Weltmann K, Lindequist U

  • Biomol Ther.
  • 2014 Nov;22(6):477-490.
  • doi: 10.4062/biomolther.2014.105
Non-thermal atmospheric-pressure plasma, also named cold plasma, is defined as a partly ionized gas. Therefore, it cannot be equated with plasma from blood; it is not biological in nature. Non-thermal...

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