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Dependence Potential of the Synthetic Cannabinoids JWH-073, JWH-081, and JWH-210: In Vivo and In Vitro Approaches

Cha HJ, Lee KW, Song MJ, Hyeon YJ, Hwang JY, Jang CG, Ahn JI, Jeon SH, Kim HU, Kim YH, Seong WK, Kang H, Yoo HS, Jeong HS

  • Biomol Ther.
  • 2014 Jul;22(4):363-369.
Synthetic cannabinoids (CBs) such as the JWH series have caused social problems concerning their abuse liability. Because the JWH series produces euphoric and hallucinogenic effects, they have been distributed illegally...
Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells

An D, Kim K, Kim J

  • Biomol Ther.
  • 2014 Jul;22(4):355-362.
We have developed a fully automated high throughput drug screening (HTDS) system based on the microfluidic cell culture array to perform combinational chemotherapy. This system has 64 individually addressable cell...
Selective Estrogen Receptor Modulation by Larrea nitida on MCF-7 Cell Proliferation and Immature Rat Uterus

Ahn HN, Jeong SY, Bae GU, Chang M, Zhang D, Liu X, Pei Y, Chin YW, Lee J, Oh SR, Song YS

  • Biomol Ther.
  • 2014 Jul;22(4):347-354.
Larrea nitida is a plant that belongs to the Zygophyllaceae family and is widely used in South America to treat inflammatory diseases, tumors and menstrual pain. However, its pharmacological activity...
Antitumor and Apoptosis Induction Effects of Paeonol on Mice Bearing EMT6 Breast Carcinoma

Ou Y, Li Q, Wang J, Li K, Zhou S

  • Biomol Ther.
  • 2014 Jul;22(4):341-346.
Paeonol is a major phenolic micromolecular component of Moutan cortex Radicis, a traditional Chinese Medicine. It has shown antitumor effects in previous studies; however, the underlying mechanisms remain unknown. This...
Anti-Inflammatory and PPAR Transactivational Effects of Oleanane-Type Triterpenoid Saponins from the Roots of Pulsatilla koreana

Li W, Yan XT, Sun YN, Ngan TT, Shim SH, Kim YH

  • Biomol Ther.
  • 2014 Jul;22(4):334-340.
In this study, 23 oleanane-type triterpenoid saponins were isolated from a methanol extract of the roots of Pulsatilla koreana. The NF-kappaB inhibitory activity of the isolated compounds was measured in...
Adipose-Derived Stem Cells Improve Efficacy of Melanocyte Transplantation in Animal Skin

Lim WS, Kim CH, Kim JY, Do BR, Kim EJ, Lee AY

  • Biomol Ther.
  • 2014 Jul;22(4):328-333.
Vitiligo is a pigmentary disorder induced by a loss of melanocytes. In addition to replacement of pure melanocytes, cocultures of melanocytes with keratinocytes have been used to improve the repigmentation...
Dermal Stability and In Vitro Skin Permeation of Collagen Pentapeptides (KTTKS and palmitoyl-KTTKS)

Choi YL, Park EJ, Kim E, Na DH, Shin YH

  • Biomol Ther.
  • 2014 Jul;22(4):321-327.
Collagen pentapeptide (Lys-Thr-Thr-Lys-Ser, KTTKS) and its palmitoylated derivative (pal-KTTKS) have received a great deal of attention as cosmeceutical ingredients for their anti-wrinkle effects. The objective of this study was to...
Pachymic Acid Enhances Pentobarbital-Induced Sleeping Behaviors via GABA(A)-ergic Systems in Mice

Shah VK, Choi JJ, Han JY, Lee MK, Hong JT, Oh KW

  • Biomol Ther.
  • 2014 Jul;22(4):314-320.
This study was investigated to know whether pachymic acid (PA), one of the predominant triterpenoids in Poria cocos (Hoelen) has the sedative-hypnotic effects, and underlying mechanisms are mediated via gamma-aminobutyric...
The Heterochromatin-1 Phosphorylation Contributes to TPA-Induced AP-1 Expression

Choi WJ

  • Biomol Ther.
  • 2014 Jul;22(4):308-313.
Activator protein-1 (AP-1) is an inducible transcription factor that contributes to the generation of chronic inflammation in response to oxidative and electrophilic stress. Previous studies have demonstrated that the PI3K/Akt1...
Fucodiphlorethol G Purified from Ecklonia cava Suppresses Ultraviolet B Radiation-Induced Oxidative Stress and Cellular Damage

Kim KC, Piao MJ, Zheng J, Yao CW, Cha JW, Kumara MH, Han X, Kang HK, Lee NH, Hyun JW

  • Biomol Ther.
  • 2014 Jul;22(4):301-307.
Fucodiphlorethol G (6'-[2,4-dihydroxy-6-(2,4,6-trihydroxyphenoxy)phenoxy]biphenyl-2,2',4,4',6-pentol) is a compound purified from Ecklonia cava, a brown alga that is widely distributed offshore of Jeju Island. This study investigated the protective effects of fucodiphlorethol G...
Cytochalasin B Modulates Macrophage-Mediated Inflammatory Responses

Kim MY, Kim JH, Cho JY

  • Biomol Ther.
  • 2014 Jul;22(4):295-300.
The actin cytoskeleton plays an important role in macrophage-mediated inflammatory responses by modulating the activation of Src and subsequently inducing nuclear factor (NF)-kappaB translocation. In spite of its critical functions,...
Anti-Inflammatory Effect of Mangostenone F in Lipopolysaccharide-Stimulated RAW264.7 Macrophages by Suppressing NF-kappaB and MAPK Activation

Cho BO, Ryu HW, So Y, Lee CW, Jin CH, Yook HS, Jeong YW, Park JC, Jeong IY

  • Biomol Ther.
  • 2014 Jul;22(4):288-294.
Mangostenone F (MF) is a natural xanthone isolated from Garcinia mangostana. However, little is known about the biological activities of MF. This study was designed to investigate the anti-inflammatory effect...
Silymarin Inhibits Cytokine-Stimulated Pancreatic Beta Cells by Blocking the ERK1/2 Pathway

Kim EJ, Kim J, Lee MY, Sudhanva M, Devakumar , Jeon YJ

  • Biomol Ther.
  • 2014 Jul;22(4):282-287.
We show that silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), inhibits cytokine mixture (CM: TNF-alpha, IFN-gamma, and IL-1beta)-induced production of nitric oxide (NO) in the pancreatic beta...
Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells

Kim HJ, Kim J, Kang KS, Lee KT, Yang HO

  • Biomol Ther.
  • 2014 Jul;22(4):275-281.
Autophagy is a series of catabolic process mediating the bulk degradation of intracellular proteins and organelles through formation of a double-membrane vesicle, known as an autophagosome, and fusing with lysosome....
Genetically Engineered Mouse Models for Drug Development and Preclinical Trials

Lee H

  • Biomol Ther.
  • 2014 Jul;22(4):267-274.
Drug development and preclinical trials are challenging processes and more than 80% to 90% of drug candidates fail to gain approval from the United States Food and Drug Administration. Predictive...

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