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Evaluation of Luminescent P450 Analysis for Directed Evolution of Human CYP4A11

Choi S, Han S, Lee H, Chun YJ, Kim D

  • Biomol Ther.
  • 2013 Nov;21(6):487-492.
Cytochrome P450 4A11 (CYP4A11) is a fatty acid hydroxylase enzyme expressed in human liver. It catalyzes not only the hydroxylation of saturated and unsaturated fatty acids, but the conversion of...
Cell Motility Is Decreased in Macrophages Activated by Cancer Cell-Conditioned Medium

Go A, Ryu YK, Lee JW, Moon EY

  • Biomol Ther.
  • 2013 Nov;21(6):481-486.
Macrophages play a role in innate immune responses to various foreign antigens. Many products from primary tumors influence the activation and transmigration of macrophages. Here, we investigated a migration of...
Impact of High Fat Diet-induced Obesity on the Plasma Levels of Monoamine Neurotransmitters in C57BL/6 Mice

Kim M, Bae S, Lim KM

  • Biomol Ther.
  • 2013 Nov;21(6):476-480.
Obesity is one of the most serious health problems in developed countries. It negatively affects diverse aspects of human wellbeing. Of these, a relationship between obesity and depression is widely...
Direct Analysis in Real Time Mass Spectrometry (DART-MS) Analysis of Skin Metabolome Changes in the Ultraviolet B-Induced Mice

Park HM, Kim HJ, Jang YP, Kim SY

  • Biomol Ther.
  • 2013 Nov;21(6):470-475.
Ultraviolet (UV) radiation is a major environmental factor that leads to acute and chronic reactions in the human skin. UV exposure induces wrinkle formation, DNA damage, and generation of reactive...
Inhibitory Effects of Eucommia ulmoides Oliv. Bark on Scopolamine-Induced Learning and Memory Deficits in Mice

Kwon SH, Ma SX, Joo HJ, Lee SY, Jang CG

  • Biomol Ther.
  • 2013 Nov;21(6):462-469.
Eucommia ulmoides Oliv. Bark (EUE) is commonly used for the treatment of hypertension, rheumatoid arthritis, lumbago, and ischialgia as well as to promote longevity. In this study, we tested the...
Neuroprotective Effects of a Butanol Fraction of Rosa hybrida Petals in a Middle Cerebral Artery Occlusion Model

Yang G, Park D, Lee SH, Bae DK, Yang YH, Kyung J, Kim D, Choi EK, Hong JT, Jeong HS, Kim HJ, Jang SK, Joo SS, Kim YB

  • Biomol Ther.
  • 2013 Nov;21(6):454-461.
The neuroprotective effects of a butanol fraction of white rose petal extract (WRPE-BF) were investigated in a middle cerebral artery occlusion (MCAO) model. Seven week-old male rats were orally administered...
A ROCK Inhibitor Blocks the Inhibitory Effect of Chondroitin Sulfate Proteoglycan on Morphological Changes of Mesenchymal Stromal/Stem Cells into Neuron-Like Cells

Lim HS, Joe YA

  • Biomol Ther.
  • 2013 Nov;21(6):447-453.
Chondroitin sulfate proteoglycan (CSPG) inhibits neurite outgrowth of various neuronal cell types, and CSPG-associated inhibition of neurite outgrowth is mediated by the Rho/ROCK pathway. Mesenchymal stromal/stem cells (MSCs) have the...
The Longevity Properties of 1,2,3,4,6-Penta-O-Galloyl-beta-D-Glucose from Curcuma longa in Caenorhabditis elegans

Ahn D, Cha DS, Lee EB, Kim BJ, Lee SY, Jeon H, Ahn MS, Lim HW, Lee HY, Kim DK

  • Biomol Ther.
  • 2013 Nov;21(6):442-446.
Here in this study, we isolated 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) from Curcuma longa L. and elucidated the lifespanextending effect of PGG using Caenorhabditis elegans model system. In the present study, PGG demonstrated...
Emodin Isolated from Polygoni cuspidati Radix Inhibits TNF-alpha and IL-6 Release by Blockading NF-kappaB and MAP Kinase Pathways in Mast Cells Stimulated with PMA Plus A23187

Lu Y, Jeong YT, Li X, Kim MJ, Park PH, Hwang SL, Son JK, Chang HW

  • Biomol Ther.
  • 2013 Nov;21(6):435-441.
Emodin, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, has several beneficial pharmacologic effects, which include anti-cancer, anti-diabetic, and anti-inflammatory activities. In this study, the authors examined the...
Nucleic Acid Aptamers: New Methods for Selection, Stabilization, and Application in Biomedical Science

Kong HY, Byun J

  • Biomol Ther.
  • 2013 Nov;21(6):423-434.
The adoption of oligonucleotide aptamer is well on the rise, serving an ever increasing demand for versatility in biomedical field. Through the SELEX (Systematic Evolution of Ligands by EXponential enrichment),...
Intercellular Lipid Mediators and GPCR Drug Discovery

Im DS

  • Biomol Ther.
  • 2013 Nov;21(6):411-422.
G-protein-coupled receptors (GPCR) are the largest superfamily of receptors responsible for signaling between cells and tissues, and because they play important physiological roles in homeostasis, they are major drug targets....

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