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11 results

Chitin from the Extract of Cuttlebone Induces Acute Inflammation and Enhances MMP1 Expression

Lee KM, Shim H, Lee GS, Park IH, Lee OS, Lim SC, Kang TJ

  • Biomol Ther.
  • 2013 May;21(3):246-250.
We previously reported that the extract from cuttlebone (CB) has wound healing effect in burned lesion of rat. In present study, the main component of CB extract was analyzed and...
Korean Red Ginseng Tonic Extends Lifespan in D. melanogaster

Kim MS

  • Biomol Ther.
  • 2013 May;21(3):241-245.
Aging is the single most important risk factor that increases susceptibility to many forms of diseases. As such, much effort has been put forward to elucidate the mechanisms behind the...
Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K

Kim JH, Son YK, Kim GH, Hwang KH

  • Biomol Ther.
  • 2013 May;21(3):234-240.
Monoamine oxidase inhibitors (MAOI) have been widely used as antidepressants. Recently, there has been renewed interest in MAO inhibitors. The activity-guided fractionation of extracts from Angelica keiskei Koidzumi (A. keiskei...
Administration of Phytoceramide Enhances Memory and Upregulates the Expression of pCREB and BDNF in Hippocampus of Mice

Lee Y, Kim J, Jang S, Oh S

  • Biomol Ther.
  • 2013 May;21(3):229-233.
This study was aimed at investigating the possible effects of phytoceramide (Pcer) on learning and memory and their underlying mechanisms. Phytoceramide was orally administered to ICR mice for 7 days....
Valproic Acid Regulates alpha-Synuclein Expression through JNK Pathway in Rat Primary Astrocytes

Kim JN, Kim MK, Cho KS, Choi CS, Park SH, Yang SI, Joo SH, Park JH, Bahn G, Shin CY, Lee HJ, Han SH, Kwon KJ

  • Biomol Ther.
  • 2013 May;21(3):222-228.
Although the role of alpha-synuclein aggregation on Parkinson's disease is relatively well known, the physiological role and the regulatory mechanism governing the expression of alpha-synuclein are unclear yet. We recently...
Aromadendrin Inhibits Lipopolysaccharide-Induced Nuclear Translocation of NF-kappaB and Phosphorylation of JNK in RAW 264.7 Macrophage Cells

Lee JW, Kim NH, Kim JY, Park JH, Shin SY, Kwon YS, Lee HJ, Kim SS, Chun W

  • Biomol Ther.
  • 2013 May;21(3):216-221.
Aromadendrin, a flavonol, has been reported to possess a variety of pharmacological activities such as anti-inflammatory, antioxidant, and anti-diabetic properties. However, the underlying mechanism by which aromadendrin exerts its biological...
Protective Effect of Fisetin (3,7,3',4'-Tetrahydroxyflavone) against gamma-Irradiation-Induced Oxidative Stress and Cell Damage

Piao MJ, Kim KC, Chae S, Keum YS, Kim HS, Hyun JW

  • Biomol Ther.
  • 2013 May;21(3):210-215.
Ionizing radiation can induce cellular oxidative stress through the generation of reactive oxygen species, resulting in cell damage and cell death. The aim of this study was to determine whether...
Transglutaminase-2 Is Involved in Expression of Osteoprotegerin in MG-63 Osteosarcoma Cells

Lee HJ, Lee CH

  • Biomol Ther.
  • 2013 May;21(3):204-209.
Osteoprotegerin (OPG) is a secreted glycoprotein and a member of the tumor necrosis factor receptor superfamily. It usually functions in bone remodeling, by inhibiting osteoclastogenesis through interaction with a receptor...
Modulation of Human Cardiac Progenitors via Hypoxia-ERK Circuit Improves their Functional Bioactivities

Jung SY, Choi SH, Yoo SY, Baek SH, Kwon SM

  • Biomol Ther.
  • 2013 May;21(3):196-203.
Recent accumulating studies have reported that hypoxic preconditioning during ex vivo expansion enhanced the self-renewal or differentiation of various stem cells and provide an important strategy for the adequate modulation...
Annexin A5 as a New Potential Biomarker for Cisplatin-Induced Toxicity in Human Kidney Epithelial Cells

Kwon YJ, Jung JJ, Park NH, Ye DJ, Kim D, Moon A, Chun YJ

  • Biomol Ther.
  • 2013 May;21(3):190-195.
Cisplatin is a member of platinum-containing anti-cancer drugs that causes cross-linking of DNA and ultimately cancer cell apoptosis. The therapeutic function of cisplatin on various types of cancers has been...
DA-9701: A New Multi-Acting Drug for the Treatment of Functional Dyspepsia

Kwon YS, Son M

  • Biomol Ther.
  • 2013 May;21(3):181-189.
Motilitone(R) (DA-9701) is a new herbal drug that was launched for the treatment of functional dyspepsia in December 2011 in Korea. The heterogeneous symptom pattern and multiple causes of functional...

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