- Hesperetin Stimulates Cholecystokinin Secretion in Enteroendocrine STC-1 Cells
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Kim HY, Park M, Kim K, Lee YM, Rhyu MR
- KMID: 1502513
- Biomol Ther.
- 2013 Mar;21(2):121-125.
Hesperetin (3',5,7-trihydroxy 4'-methoxyflavanone) and its glycoside hesperidin (hesperetin 7-rhamnoglucoside) in oranges have been reported to possess pharmacological effects related to anti-obesity. However, hesperetin and hesperidin have not been studied on... -
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- Targeting Cellular Antioxidant Enzymes for Treating Atherosclerotic Vascular Disease
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Kang DH, Kang SW
- KMID: 1502509
- Biomol Ther.
- 2013 Mar;21(2):89-96.
Atherosclerotic vascular dysfunction is a chronic inflammatory process that spreads from the fatty streak and foam cells through lesion progression. Therefore, its early diagnosis and prevention is unfeasible. Reactive oxygen... -
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- The Spermatogenic Effect of Yacon Extract and Its Constituents and Their Inhibition Effect of Testosterone Metabolism
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Park JS, Han K
- KMID: 1502518
- Biomol Ther.
- 2013 Mar;21(2):153-160.
We screened the pharmacological effects of a 50% ethanol extract of Yacon tubers and leaves on spermatogenesis in rats. As a result, we found that Yacon tuber extracts increased sperm... -
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- Protective Effects of Geniposide and Genipin against Hepatic Ischemia/Reperfusion Injury in Mice
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Kim J, Kim HY, Lee SM
- KMID: 1502515
- Biomol Ther.
- 2013 Mar;21(2):132-137.
Geniposide is an active product extracted from the gardenia fruit, and is one of the most widely used herbal preparations for liver disorders. This study examined the cytoprotective properties of... -
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- Interaction of Hepatitis C Virus Core Protein with Janus Kinase Is Required for Efficient Production of Infectious Viruses
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Lee C
- KMID: 1502510
- Biomol Ther.
- 2013 Mar;21(2):97-106.
Chronic hepatitis C virus (HCV) infection is responsible for the development of liver cirrhosis and hepatocellular carcinoma. HCV core protein plays not only a structural role in the virion morphogenesis... -
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- Anti-Inflammatory Effect of Quercetagetin, an Active Component of Immature Citrus unshiu, in HaCaT Human Keratinocytes
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Kang GJ, Han SC, Ock JW, Kang HK, Yoo ES
- KMID: 1502516
- Biomol Ther.
- 2013 Mar;21(2):138-145.
Citrus fruit contain various flavonoids that have multiple biological activities. However, the content of these flavonoids are changed during maturation and immature Citrus is known to contain larger amounts than... -
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- Self-Nanoemulsifying Drug Delivery System of Lutein: Physicochemical Properties and Effect on Bioavailability of Warfarin
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Yoo J, Baskaran R, Yoo BK
- KMID: 1502521
- Biomol Ther.
- 2013 Mar;21(2):173-179.
Objective of present study was to prepare and characterize self-nanoemulsifying drug delivery system (SNEDDS) of lutein and to evaluate its effect on bioavailability of warfarin. The SNEDDS was prepared using... -
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- Identification of Differentially Expressed Genes by Gabapentin in Cultured Dorsal Root Ganglion in a Rat Neuropathic Pain Model
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Heo JH, Lee SH, Chang KH, Han EH, Lee SG, Choi DW, Kim SW
- KMID: 1502514
- Biomol Ther.
- 2013 Mar;21(2):126-131.
Neuropathic pain is a chronic pain disorder caused by nervous system lesions as a direct consequence of a lesion or by disease of the portions of the nervous system that... -
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- Pharmacokinetics of Uridine Following Ocular, Oral and Intravenous Administration in Rabbits
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Kim E, Kang W
- KMID: 1502520
- Biomol Ther.
- 2013 Mar;21(2):170-172.
The pyrimidine nucleoside uridine has recently been reported to have a protective effect on cultured human corneal epithelial cells, in an animal model of dry eye and in patients. In... -
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- Autophagy-Dependent Survival of Mutant B-Raf Melanoma Cells Selected for Resistance to Apoptosis Induced by Inhibitors against Oncogenic B-Raf
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Ahn JH, Lee M
- KMID: 1502512
- Biomol Ther.
- 2013 Mar;21(2):114-120.
Most patients with mutant B-Raf melanomas respond to inhibitors of oncogenic B-Raf but resistance eventually emerges. To better understand the mechanisms that determine the long-term responses of mutant B-Raf melanoma... -
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- Zanamivir Oral Delivery: Enhanced Plasma and Lung Bioavailability in Rats
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Shanmugam , Im HT, Sohn YT, Kim KS, Kim YI, Yong CS, Kim JO, Choi HG, Woo JS
- KMID: 1502519
- Biomol Ther.
- 2013 Mar;21(2):161-169.
The objective of this study was to enhance the oral bioavailability (BA) of zanamivir (ZMR) by increasing its intestinal permeability using permeation enhancers (PE). Four different classes of PEs (Labrasol(R),... -
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- A Methanol Extract of Adansonia digitata L. Leaves Inhibits Pro-Inflammatory iNOS Possibly via the Inhibition of NF-kappaB Activation
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Ayele Y, Kim JA, Park E, Kim YJ, Retta N, Dessie G, Rhee SK, Koh K, Nam KW, Kim HS
- KMID: 1502517
- Biomol Ther.
- 2013 Mar;21(2):146-152.
This study examined the total polyphenol content of eight wild edible plants from Ethiopia and their effect on NO production in Raw264.7 cells. Owing to its relatively high polyphenol concentration... -
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- Transcriptional Upregulation of Plasminogen Activator Inhibitor-1 in Rat Primary Astrocytes by a Proteasomal Inhibitor MG132
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Cho KS, Kwon KJ, Jeon SJ, Joo SH, Kim KC, Cheong JH, Bahn GH, Kim HY, Han SH, Shin CY, Yang SI
- KMID: 1502511
- Biomol Ther.
- 2013 Mar;21(2):107-113.
Plasminogen activator inhibitor-1 (PAI-1) is a member of serine protease inhibitor family, which regulates the activity of tissue plasminogen activator (tPA). In CNS, tPA/PAI-1 activity is involved in the regulation... -
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