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Self-Nanoemulsifying Drug Delivery System of Lutein: Physicochemical Properties and Effect on Bioavailability of Warfarin

Yoo J, Baskaran R, Yoo BK

  • Biomol Ther.
  • 2013 Mar;21(2):173-179.
Objective of present study was to prepare and characterize self-nanoemulsifying drug delivery system (SNEDDS) of lutein and to evaluate its effect on bioavailability of warfarin. The SNEDDS was prepared using...
Pharmacokinetics of Uridine Following Ocular, Oral and Intravenous Administration in Rabbits

Kim E, Kang W

  • Biomol Ther.
  • 2013 Mar;21(2):170-172.
The pyrimidine nucleoside uridine has recently been reported to have a protective effect on cultured human corneal epithelial cells, in an animal model of dry eye and in patients. In...
Zanamivir Oral Delivery: Enhanced Plasma and Lung Bioavailability in Rats

Shanmugam , Im HT, Sohn YT, Kim KS, Kim YI, Yong CS, Kim JO, Choi HG, Woo JS

  • Biomol Ther.
  • 2013 Mar;21(2):161-169.
The objective of this study was to enhance the oral bioavailability (BA) of zanamivir (ZMR) by increasing its intestinal permeability using permeation enhancers (PE). Four different classes of PEs (Labrasol(R),...
The Spermatogenic Effect of Yacon Extract and Its Constituents and Their Inhibition Effect of Testosterone Metabolism

Park JS, Han K

  • Biomol Ther.
  • 2013 Mar;21(2):153-160.
We screened the pharmacological effects of a 50% ethanol extract of Yacon tubers and leaves on spermatogenesis in rats. As a result, we found that Yacon tuber extracts increased sperm...
A Methanol Extract of Adansonia digitata L. Leaves Inhibits Pro-Inflammatory iNOS Possibly via the Inhibition of NF-kappaB Activation

Ayele Y, Kim JA, Park E, Kim YJ, Retta N, Dessie G, Rhee SK, Koh K, Nam KW, Kim HS

  • Biomol Ther.
  • 2013 Mar;21(2):146-152.
This study examined the total polyphenol content of eight wild edible plants from Ethiopia and their effect on NO production in Raw264.7 cells. Owing to its relatively high polyphenol concentration...
Anti-Inflammatory Effect of Quercetagetin, an Active Component of Immature Citrus unshiu, in HaCaT Human Keratinocytes

Kang GJ, Han SC, Ock JW, Kang HK, Yoo ES

  • Biomol Ther.
  • 2013 Mar;21(2):138-145.
Citrus fruit contain various flavonoids that have multiple biological activities. However, the content of these flavonoids are changed during maturation and immature Citrus is known to contain larger amounts than...
Protective Effects of Geniposide and Genipin against Hepatic Ischemia/Reperfusion Injury in Mice

Kim J, Kim HY, Lee SM

  • Biomol Ther.
  • 2013 Mar;21(2):132-137.
Geniposide is an active product extracted from the gardenia fruit, and is one of the most widely used herbal preparations for liver disorders. This study examined the cytoprotective properties of...
Identification of Differentially Expressed Genes by Gabapentin in Cultured Dorsal Root Ganglion in a Rat Neuropathic Pain Model

Heo JH, Lee SH, Chang KH, Han EH, Lee SG, Choi DW, Kim SW

  • Biomol Ther.
  • 2013 Mar;21(2):126-131.
Neuropathic pain is a chronic pain disorder caused by nervous system lesions as a direct consequence of a lesion or by disease of the portions of the nervous system that...
Hesperetin Stimulates Cholecystokinin Secretion in Enteroendocrine STC-1 Cells

Kim HY, Park M, Kim K, Lee YM, Rhyu MR

  • Biomol Ther.
  • 2013 Mar;21(2):121-125.
Hesperetin (3',5,7-trihydroxy 4'-methoxyflavanone) and its glycoside hesperidin (hesperetin 7-rhamnoglucoside) in oranges have been reported to possess pharmacological effects related to anti-obesity. However, hesperetin and hesperidin have not been studied on...
Autophagy-Dependent Survival of Mutant B-Raf Melanoma Cells Selected for Resistance to Apoptosis Induced by Inhibitors against Oncogenic B-Raf

Ahn JH, Lee M

  • Biomol Ther.
  • 2013 Mar;21(2):114-120.
Most patients with mutant B-Raf melanomas respond to inhibitors of oncogenic B-Raf but resistance eventually emerges. To better understand the mechanisms that determine the long-term responses of mutant B-Raf melanoma...
Transcriptional Upregulation of Plasminogen Activator Inhibitor-1 in Rat Primary Astrocytes by a Proteasomal Inhibitor MG132

Cho KS, Kwon KJ, Jeon SJ, Joo SH, Kim KC, Cheong JH, Bahn GH, Kim HY, Han SH, Shin CY, Yang SI

  • Biomol Ther.
  • 2013 Mar;21(2):107-113.
Plasminogen activator inhibitor-1 (PAI-1) is a member of serine protease inhibitor family, which regulates the activity of tissue plasminogen activator (tPA). In CNS, tPA/PAI-1 activity is involved in the regulation...
Interaction of Hepatitis C Virus Core Protein with Janus Kinase Is Required for Efficient Production of Infectious Viruses

Lee C

  • Biomol Ther.
  • 2013 Mar;21(2):97-106.
Chronic hepatitis C virus (HCV) infection is responsible for the development of liver cirrhosis and hepatocellular carcinoma. HCV core protein plays not only a structural role in the virion morphogenesis...
Targeting Cellular Antioxidant Enzymes for Treating Atherosclerotic Vascular Disease

Kang DH, Kang SW

  • Biomol Ther.
  • 2013 Mar;21(2):89-96.
Atherosclerotic vascular dysfunction is a chronic inflammatory process that spreads from the fatty streak and foam cells through lesion progression. Therefore, its early diagnosis and prevention is unfeasible. Reactive oxygen...

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