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Chronic Administration of Catechin Decreases Depression and Anxiety-Like Behaviors in a Rat Model Using Chronic Corticosterone Injections

Lee B, Sur B, Kwon S, Yeom M, Shim I, Lee H, Hahm DH

  • Biomol Ther.
  • 2013 Jul;21(4):313-322.
Previous studies have demonstrated that repeated administration of the exogenous stress hormone corticosterone (CORT) induces dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis and results in depression and anxiety. The current study...
Dependence Potential of Quetiapine: Behavioral Pharmacology in Rodents

Cha HJ, Lee HA, Ahn JI, Jeon SH, Kim EJ, Jeong HS

  • Biomol Ther.
  • 2013 Jul;21(4):307-312.
Quetiapine is an atypical or second-generation antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. However,...
Ethanolic Extract of the Seed of Zizyphus jujuba var. spinosa Ameliorates Cognitive Impairment Induced by Cholinergic Blockade in Mice

Lee HE, Lee SY, Kim JS, Park SJ, Kim JM, Lee YW, Jung JM, Kim DH, Shin BY, Jang DS, Kang SS, Ryu JH

  • Biomol Ther.
  • 2013 Jul;21(4):299-306.
In the present study, we investigated the effect of ethanolic extract of the seed of Zizyphus jujuba var. spinosa (EEZS) on cholinergic blockade-induced memory impairment in mice. Male ICR mice...
Effects of Calcium Gluconate, a Water Soluble Calcium Salt on the Collagen-Induced DBA/1J Mice Rheumatoid Arthritis

Sohn KC, Kang SJ, Kim JW, Kim KY, Ku SK, Lee YJ

  • Biomol Ther.
  • 2013 Jul;21(4):290-298.
This study examined the effects of calcium (Ca) gluconate on collagen-induced DBA mouse rheumatoid arthritis (CIA). A single daily dose of 200, 100 or 50 mg/kg Ca gluconate was administered...
Antidiabetic and Beta Cell-Protection Activities of Purple Corn Anthocyanins

Hong SH, Heo JI, Kim JH, Kwon SO, Yeo KM, Bakowska-Barczak AM, Kolodziejczyk P, Ryu OH, Choi MK, Kang YH, Lim SS, Suh HW, Huh SO, Lee JY

  • Biomol Ther.
  • 2013 Jul;21(4):284-289.
Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin...
Inhibitory Effect of an Urotensin II Receptor Antagonist on Proinflammatory Activation Induced by Urotensin II in Human Vascular Endothelial Cells

Park SL, Lee BK, Kim YA, Lee BH, Jung YS

  • Biomol Ther.
  • 2013 Jul;21(4):277-283.
In this study, we investigated the effects of a selective urotensin II (UII) receptor antagonist, SB-657510, on the inflammatory response induced by UII in human umbilical vein endothelial cells (EA.hy926)...
Fucoxanthin Protects Cultured Human Keratinocytes against Oxidative Stress by Blocking Free Radicals and Inhibiting Apoptosis

Zheng J, Piao MJ, Keum YS, Kim HS, Hyun JW

  • Biomol Ther.
  • 2013 Jul;21(4):270-276.
Fucoxanthin is an important carotenoid derived from edible brown seaweeds and is used in indigenous herbal medicines. The aim of the present study was to examine the cytoprotective effects of...
Silymarin's Protective Effects and Possible Mechanisms on Alcoholic Fatty Liver for Rats

Zhang W, Hong R, Tian T

  • Biomol Ther.
  • 2013 Jul;21(4):264-269.
Silymarin has been introduced fairly recently as a hepatoprotective agent. But its mechanisms of action still have not been well established. The aim of this study was to make alcoholic...
Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38 MAPK in RAW 264.7 Cells

Youn CK, Park SJ, Lee MY, Cha MJ, Kim OH, You HJ, Chang IY, Yoon SP, Jeon YJ

  • Biomol Ther.
  • 2013 Jul;21(4):258-263.
We demonstrate herein that silibinin, a polyphenolic flavonoid compound isolated from milk thistle (Silybum marianum), inhibits LPS-induced activation of macrophages and production of nitric oxide (NO) in RAW 264.7 cells....
Sphingolipids and Antimicrobial Peptides: Function and Roles in Atopic Dermatitis

Park K, Lee S, Lee YM

  • Biomol Ther.
  • 2013 Jul;21(4):251-257.
Inflammatory skin diseases such as atopic dermatitis (AD) and rosacea were complicated by barrier abrogation and deficiency in innate immunity. The first defender of epidermal innate immune response is the...

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