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Histopathological Evaluation of Heart Toxicity of a Novel Selective PPAR-gamma Agonists CKD-501 in db/db Mice

Yang HI, Kim WS, Kim DH, Kang JS

  • Biomol Ther.
  • 2013 Jan;21(1):84-88.
High risk of cardiovascular diseases caused by existing PPAR-gamma agonists such as rosiglitazone and pioglitazone has been recently reported. CKD-501 is a novel selective PPAR-gamma agonist as a potential target...
Antidepressant-Like Effects of Lycii Radicis Cortex and Betaine in the Forced Swimming Test in Rats

Kim SJ, Lee MS, Kim JH, Lee TH, Shim I

  • Biomol Ther.
  • 2013 Jan;21(1):79-83.
The purpose of the present study was to examine the effect of Lycii Radicis Cortex (LRC) and betaine (BT) on immobility and neurochemical change in the forced swimming test (FST)...
Anti-Inflammatory, Antioxidant, Anti-Angiogenic and Skin Whitening Activities of Phryma leptostachya var. asiatica Hara Extract

Jung HJ, Cho YW, Lim HW, Choi H, Ji DJ, Lim CJ

  • Biomol Ther.
  • 2013 Jan;21(1):72-78.
This work aimed to assess some pharmacological activities of P. leptostachya var. asiatica Hara. The dried roots of P. leptostachya var. asiatica Hara were extracted with 70% ethanol to generate...
Inhibition of Experimental Systemic Inflammation (Septic Inflammation) and Chronic Bronchitis by New Phytoformula BL Containing Broussonetia papyrifera and Lonicera japonica

Ko HJ, Kwon OS, Jin JH, Son KH, Kim HP

  • Biomol Ther.
  • 2013 Jan;21(1):66-71.
Broussonetia papyrifera and Lonicera japonica have long been used in the treatment of inflammatory disorders in Chinese medicine, especially respiratory inflammation. Previously, a new phytoformula (BL) containing B. papyrifera and...
3,4,5-Trihydroxycinnamic Acid Inhibits Lipopolysaccharide-Induced Inflammatory Response through the Activation of Nrf2 Pathway in BV2 Microglial Cells

Lee JW, Choi YJ, Park JH, Sim JY, Kwon YS, Lee HJ, Kim SS, Chun W

  • Biomol Ther.
  • 2013 Jan;21(1):60-65.
3,4,5-Trihydroxycinnamic acid (THC) is a derivative of hydroxycinnamic acids, which have been reported to possess a variety of biological properties such as anti-inflammatory, anti-tumor, and neuroprotective activities. However, biological activity...
Inhibitory Effects of Epigallocatechin-3-Gallate on Microsomal Cyclooxygenase-1 Activity in Platelets

Lee DH, Kim YJ, Kim HH, Cho HJ, Ryu JH, Rhee MH, Park HJ

  • Biomol Ther.
  • 2013 Jan;21(1):54-59.
In this study, we investigated the effect of (-)-epigallocatechin-3-gallate (EGCG), a major component of green tea catechins from green tea leaves, on activities of cyclooxygenase (COX)-1 and thromboxane synthase (TXAS),...
Finasteride Increases the Expression of Hemoxygenase-1 (HO-1) and NF-E2-Related Factor-2 (Nrf2) Proteins in PC-3 Cells: Implication of Finasteride-Mediated High-Grade Prostate Tumor Occurrence

Yun DK, Lee J, Keum YS

  • Biomol Ther.
  • 2013 Jan;21(1):49-53.
A number of naturally-occurring or synthetic chemicals have been reported to exhibit prostate chemopreventive effects. Synthetic 5alpha-reductase (5-AR) inhibitors, e.g. finasteride and durasteride, gained special interests as possible prostate chemopreventive...
The Cholesterol-Binding Antibiotic Nystatin Induces Expression of Macrophage Inflammatory Protein-1 in Macrophages

Baek S, Kim SM, Lee SA, Rhim BY, Eo SK, Kim K

  • Biomol Ther.
  • 2013 Jan;21(1):42-48.
Nystatin, a polyene antifungal antibiotic, is a cholesterol sequestering agent. The antifungal agent alters composition of the plasma membrane of eukaryotic cells, whereas its effects on cells are poorly investigated....
Metformin Suppresses MHC-Restricted Antigen Presentation by Inhibiting Co-Stimulatory Factors and MHC Molecules in APCs

Shin S, Hyun B, Lee A, Kong H, Han S, Lee CK, Ha NJ, Kim K

  • Biomol Ther.
  • 2013 Jan;21(1):35-41.
Metformin is widely used for T2D therapy but its cellular mechanism of action is undefined. Recent studies on the mechanism of metformin in T2D have demonstrated involvement of the immune...
Down-Regulation of Survivin by Nemadipine-A Sensitizes Cancer Cells to TRAIL-Induced Apoptosis

Park SH, Park SJ, Kim JO, Shin JH, Kim ES, Jo YK, Kim JS, Park SJ, Jin DH, Hwang JJ, Lee SJ, Jeong SY, Lee C, Kim I, Cho DH

  • Biomol Ther.
  • 2013 Jan;21(1):29-34.
The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor family of cytokines. TRAIL selectively induces apoptotic cell death in various tumors and cancer...
Activation of Autophagy Pathway Suppresses the Expression of iNOS, IL6 and Cell Death of LPS-Stimulated Microglia Cells

Han HE, Kim TK, Son HJ, Park WJ, Han PL

  • Biomol Ther.
  • 2013 Jan;21(1):21-28.
Microglia play a role in maintaining and resolving brain tissue homeostasis. In pathological conditions, microglia release pro-inflammatory cytokines and cytotoxic factors, which aggravate the progression of neurodegenerative diseases. Autophagy pathway...
Emerging Roles of Human Prostatic Acid Phosphatase

Kong HY, Byun J

  • Biomol Ther.
  • 2013 Jan;21(1):10-20.
Prostate cancer is one of the most prevalent non-skin related cancers. It is the second leading cause of cancer deaths among males in most Western countries. If prostate cancer is...
Polyamines and Their Metabolites as Diagnostic Markers of Human Diseases

Park MH, Igarashi K

  • Biomol Ther.
  • 2013 Jan;21(1):1-9.
Polyamines, putrescine, spermidine and spermine, are ubiquitous in living cells and are essential for eukaryotic cell growth. These polycations interact with negatively charged molecules such as DNA, RNA, acidic proteins...

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