Skip Navigation
Skip to contents
Results by Year

View Wide

Filter

ARTICLE TYPE

more+
SELECT FILTER
 
Close

PUBLICATION DATE

45 results
Display

Safety and Efficacy of Elobixibat, an Ileal Bile Acid Transporter Inhibitor, in Elderly Patients With Chronic Idiopathic Constipation According to Administration Time: Interim Analysis of Post-marketing Surveillance

Nakajima A, Fujimaki M, Arai Y, Emori K

  • KMID: 2531217
  • J Neurogastroenterol Motil.
  • 2022 Jul;28(3):431-441.
  • doi: 10.5056/jnm20263
Background/Aims Elobixibat, an ileal bile acid transporter (apical sodium-dependent bile acid transporter) inhibitor, was recently launched in Japan for the treatment of chronic idiopathic constipation. We conducted an interim analysis of...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Lithocholic Acid Activates Mas-Related G Protein-Coupled Receptors, Contributing to Itch in Mice

Song MH, Shim WS

The present study focused on lithocholic acid (LCA), a secondary bile acid that contributes to cholestatic pruritus. Although recent studies have found that LCA acts on MAS-related G protein-coupled receptor...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Bile Acid Receptors in Cholangiocyte

Park JM

Bile acids are known to play a role in helping the digestion of lipid and maintenance of the bile flow. However, since the first bile acid receptor was discovered in...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Recent advances in nonalcoholic fatty liver disease metabolomics

Kim HY

The clinical phenotypes of nonalcoholic fatty liver disease (NAFLD) encompass from simple steatosis to nonalcoholic steatohepatitis (NASH) with varying degrees of fibrosis or cirrhosis. Liver biopsy has been the standard...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
The effect of bile acids on Porphyromonas gingivalis lipopolysaccharide-induced inflammatory response

PARK JA

Objectives: In this study, I aimed to evaluate the inhibitory effect of bile acids on the inflammatory response and osteoclastogenesis in RAW 264.7 cells activated through lipopolysaccharide (LPS) and receptor...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Bile Acid Transporters Are Expressed and Heterogeneously Distributed in Rat Bile Ducts

Luo ZL, Cheng L, Wang T, Tang LJ, Tian FZ, Xiang K, Cui L

BACKGROUND/AIMS: Cholangiocytes are capable of reabsorbing bile salts from bile, but the pathophysiological significance of this process is unclear. To this end, we detected the expression and distribution of bile...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets

Ferrell JM, Chiang JY

Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Crosstalk between FXR and TGR5 controls glucagon-like peptide 1 secretion to maintain glycemic homeostasis

Kim H, Fang S

Though bile acids have been well known as digestive juice, recent studies have demonstrated that bile acids bind to their endogenous receptors, including Farnesoid X receptor (FXR) and G protein-coupled...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Bile Acids and the Metabolic Disorders

Roh JH, Yoon JH

Bile acids are major constituents of bile and known to help absorb dietary fat and fat-soluble vitamins in the gastrointestinal tract. In the past few decades, many studies have shown...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Complete Recovery of Oxysterol 7α-Hydroxylase Deficiency by Living Donor Transplantation in a 4-Month-Old Infant: the First Korean Case Report and Literature Review

Hong J, Oh SH, Yoo HW, Nittono H, Kimura A, Kim KM

Oxysterol 7α-hydroxylase deficiency is a very rare liver disease categorized as inborn errors of bile acid synthesis, caused by CYP7B1 mutations. As it may cause rapid progression to end-stage liver...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
The Effect of Microbiota on Colon Carcinogenesis

Yoon K, Kim N

Although genetic background is known to contribute to colon carcinogenesis, the exact etiology of the disease remains elusive. The organ’s extensive interaction with microbes necessitated research on the role of...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
The Role of Bile Acid Receptors in Chronic Inflammatory Diseases

Park R, Ji JD

With recent developments, biologic therapies has shown superior efficacy for rheumatic diseases compared with preexisting pharmacologic therapies, which are associated with high costs, non-response in certain patient groups, and severe...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Bile Acid Receptor Farnesoid X Receptor: A Novel Therapeutic Target for Metabolic Diseases

Fang S

Bile acid has been well known to serve as a hormone in regulating transcriptional activity of Farnesoid X receptor (FXR), an endogenous bile acid nuclear receptor. Moreover, bile acid regulates...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for Nonalcoholic Fatty Liver Disease

Kim SG, Kim BK, Kim K, Fang S

Nonalcoholic fatty liver disease (NAFLD) is one of the causes of fatty liver, occurring when fat is accumulated in the liver without alcohol consumption. NAFLD is the most common liver...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Implications for Farnesoid X Receptor Signaling on Bile Acid Metabolism as a Potential Therapeutic Strategy for Nonalcoholic Fatty Liver Disease

Yang H, Park CY

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in both developed and developing countries and is an important risk factor for both hepatic and cardiometabolic mortality....
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Preventing a Mass Disease: The Case of Gallstones Disease: Role and Competence for Family Physicians

Portincasa P, Di Ciaula , Grattagliano I

Gallstone formation is the result of a complex interaction between genetic and nongenetic factors. We searched and reviewed the available literature to define how the primary prevention of gallstones (cholesterol...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Thyroid Hormone Regulates the mRNA Expression of Small Heterodimer Partner through Liver Receptor Homolog-1

Ahn HY, Kim HH, Kim YA, Kim M, Ohn JH, Chung SS, Lee YK, Park DJ, Park KS, Moore DD, Park YJ

BACKGROUND: Expression of hepatic cholesterol 7alpha-hydroxylase (CYP7A1) is negatively regulated by orphan nuclear receptor small heterodimer partner (SHP). In this study, we aimed to find whether thyroid hormone regulates SHP...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Pharmacologic Agents for Chronic Diarrhea

Lee KJ

Chronic diarrhea is usually associated with a number of non-infectious causes. When definitive treatment is unavailable, symptomatic drug therapy is indicated. Pharmacologic agents for chronic diarrhea include loperamide, 5-hydroxytryptamine type...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Emerging Pharmacologic Therapies for Constipation-predominant Irritable Bowel Syndrome and Chronic Constipation

Eswaran S, Guentner A, Chey WD

  • KMID: 2381166
  • J Neurogastroenterol Motil.
  • 2014 Apr;20(2):141-151.
Irritable bowel syndrome with constipation and chronic functional constipation are common digestive disorders that negatively impact quality of life and account for billions of dollars in health care costs. Related...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Bile Acid Inhibition of N-type Calcium Channel Currents from Sympathetic Ganglion Neurons

Lee HK, Lee KH, Cho ES

Under some pathological conditions as bile flow obstruction or liver diseases with the enterohepatic circulation being disrupted, regurgitation of bile acids into the systemic circulation occurs and the plasma level...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close

Go to Top

Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr