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Various Three-Dimensional Culture Methods and Cell Types for Exosome Production

Lee DH, Yun DW, Kim YH, Im GB, Hyun J, Park HS, Bhang SH, Choi SH

Cell-based therapies have been used as promising treatments for several untreatable diseases. However, cellbased therapies have side effects such as tumorigenesis and immune responses. To overcome these side effects, therapeutic...
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Silica-Based Advanced Nanoparticles For Treating Ischemic Disease

Kudaibergen D, Park HS, Park J, Im GB, Lee JR, Joung YK, Bhang SH, Kim JH

Recently, various attempts have been made to apply diverse types of nanoparticles in biotechnology. Silica nanoparticles (SNPs) have been highlighted and studied for their selective accumulation in diseased parts, strong...
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Development of Hetero-Cell Type Spheroids Via Core–Shell Strategy for Enhanced Wound Healing Effect of Human AdiposeDerived Stem Cells

Lee DH, Bhang SH

BACKGROUND: Stem cell-based therapies have been developed to treat various types of wounds. Human adiposederived stem cells (hADSCs) are used to treat skin wounds owing to their outstanding angiogenic potential....
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Silica-Capped and Gold-Decorated Silica Nanoparticles for Enhancing Effect of Gold Nanoparticle-Based Photothermal Therapy

Park JH, Choe HS, Kim SW, Im GB, Um SH, Kim JH, Bhang SH

BACKGROUND: Various methods based on gold nanoparticles (AuNPs) have been applied to enhance the photothermal effect. Among these methods, combining gold nanoparticles and stem cells has been suggested as a...
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Enhancing the Angiogenic and Proliferative Capacity of Dermal Fibroblasts with Mulberry ( Morus alba. L) Root Extract

Im J, Hyun J, Kim SW, Bhang SH

BACKGROUND: Enhancing blood flow and cell proliferation in the hair dermis is critical for treating hair loss. This study was designed to aid the development of alternative and effective solutions...
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Metal Ion Releasing Gold Nanoparticles for Improving Therapeutic Efficiency of Tumor Targeted Photothermal Therapy

Park JH, Jung E, Lim H, Lee JR, Joung YK, Yu T, Bhang SH

BACKGROUND: Owing to the tumor-targeted migration capacity of human mesenchymal stem cells (hMSCs), they have been combined with nanoparticles for photothermal therapy. However, the low viability of hMSCs following transplantation...
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Enhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma

Yang HS, Shin J, Bhang SH, Shin JY, Park J, Im GI, Kim CS, Kim BS

Platelet-rich plasma (PRP) contains growth factors that promote tissue regeneration. Previously, we showed that heparin-conjugated fibrin (HCF) exerts the sustained release of growth factors with affinity for heparin. Here, we...
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Enhanced Anti-Cancer Effects of Conditioned Medium from Hypoxic Human Umbilical Cord–Derived Mesenchymal Stem Cells

Han KH, Kim AK, Jeong GJ, Jeon HR, Bhang SH, Kim DI

BACKGROUND AND OBJECTIVES: There have been contradictory reports on the pro-cancer or anti-cancer effects of mesenchymal stem cells. In this study, we investigated whether conditioned medium (CM) from hypoxic human...
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