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A Report of Two Case of Ocular Toxicity Resulting from Direct or Indirect Bee Venom

Lee CH, Lee CH, Chang MH, Seo YS

PURPOSE: To report a patient stung by a bee, who was diagnosed with sterile endopthalmitis and another patient diagnosed with optic neuritis, with decreasing visual acuity, after refined bee venom...
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Evaluation of Antifungal Activities of Bee Venom Components Against Malassezia Strains

Kim JH, Park J, Park KK, An HJ, Lee YW

BACKGROUND: Several studies about bee venom components have reported anti-fungal, anti-inflammatory, and anti-cancer effects. Malassezia species are components of skin flora, and also associated with many dermatologic diseases such as...
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Bee venom stimulation of a lung meridian acupoint reduces inflammation in carrageenan-induced pleurisy: an alternative therapeutic approach for respiratory inflammation

Choi HS, Kang SY, Roh DH, Choi SR, Ryu Y, Lee JH

Respiratory inflammation is a frequent and fatal pathologic state encountered in veterinary medicine. Although diluted bee venom (dBV) has potent anti-inflammatory effects, the clinical use of dBV is limited to...
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Late-Onset Post-radiation Lymphedema Provoked by Bee Venom Therapy: A Case Report

Seo YJ, Jeong YS, Park HS, Park SW, Choi JY, Jung KJ, Lim JY

Lymphedema is a common complication associated with cancer itself or with cancer treatment. Lymphedema infrequently occurs after drug therapy. Bee venom is one of the materials used in acupuncture, and...
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Guillain-barré Syndrome after Multiple Bee Stings

Jin SC

Severe systemic responses including neurologic complications such as myasthenia gravis, myeloradiculopathy, optic neuropathy, parkinsonism, stroke and Guillain-barré syndrome can occur after bee stings. This case describes a 78-year-old female who...
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Antifungal Effects of Bee Venom Components on Trichophyton rubrum: A Novel Approach of Bee Venom Study for Possible Emerging Antifungal Agent

Park J, Kwon O, An HJ, Park KK

BACKGROUND: Bee venom (BV) has been widely investigated for potential medical uses. Recent inadvertent uses of BV based products have shown to mitigate signs of fungal infections. However, the component...
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Venom allergy, risk factors for systemic reactions and the knowledge levels among Turkish beekeepers

Ediger D, Terzioglu , Ozturk RT

BACKGROUND: Allergic reactions developing after bee sting can be severe and life-threatening. According to epidemiological data, serious systemic reactions range between 1.2%–3%, and this is 2–3 times higher (6%) in...
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Widespread Lumbosacral Subdural Abscess after Bee Venom Therapy: A Case Report

Choi JC, Lee YS, Eun DC, Byun CW

STUDY DESIGN: Case report. OBJECTIVES: We report a case of widespread lumbosacral subdural abscess in a patient who underwent bee venom therapy. SUMMARY OF LITERATURE REVIEW: Subdural abscess is rare, but has...
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Combination of omalizumab and bee venom immunotherapy: does it work?

Yılmaz I, Bahçecioğlu SN, Türk M

Bee venom immunotherapy (b-VIT) can be combined with omalizumab therapy in order to suppress systemic reactions developing due to b-VIT itself. Omalizumab acts as a premedication and gains time for...
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Severe Ulnar Nerve Injury After Bee Venom Acupuncture at a Traditional Korean Medicine Clinic: A Case Report

Park JS, Park YG, Jang CH, Cho YN, Park JH

This case report describes a severe nerve injury to the right ulnar nerve, caused by bee venom acupuncture. A 52-year-old right-handed man received bee venom acupuncture on the medial side...
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Phospholipase A2 isolated from the venom of honey bees prevents viral attachment in mammalian cells

Hewawaduge CY, Lee BH, Kim TH, Uddin MB, Kim JH, Kim CG, Lee JS

The belief that honey bee venom (BV) can be used to treat certain immune-related diseases, such as arthritis and rheumatic conditions, goes back to antiquity. A growing number of reports...
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Bee venom phospholipase A2 ameliorates motor dysfunction and modulates microglia activation in Parkinson's disease alpha-synuclein transgenic mice

Ye M, Chung HS, Lee C, Song JH, Shim I, Kim YS, Bae H

α-Synuclein (α-Syn) has a critical role in microglia-mediated neuroinflammation, which leads to the development of Parkinson's disease (PD). Recent studies have shown that bee venom (BV) has beneficial effects on...
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AKI and Takotsubo Cardiomyopathy after Bee Venom-induced Anaphylaxis

Cheon MJ, Yoon BW, Song Y, Lee CK, Lee TY, Cho IS, Hong JY

Bee venom-induced anaphylaxis usually causes urticaria, angioedema, respiratory distress, nausea, and vomiting. Occasionally, it leads to unusual complications such as acute myocardial infarction, takotsubo cardiomyopathy, arrhythmia, rhabdomyolysis, intravascular hemolysis, and...
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Bee Venom Exerts Neuroprotective Effects on Neuronal Cells and Astrocytes under Hypoxic Conditions Through MAPK Signaling Pathways

Lee EJ, Kim BJ, Jeong JE, Chung HL, Yang EK, Kim WT

PURPOSE: Hypoxic-ischemic brain injuries influence the mechanisms of signal transduction, including mitogen-activated protein kinase (MAPK) that regulates gene expression through transcription factor activity. Several attempts have been made to use...
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Lower limb ischemia after bee sting

Ryu HY, Yoo MS, Park JY, Choi JW, Ryu SK, Kim S, Lee SJ, Kim YB

Bee sting causes mild symptoms such as urticaria and localized pain, and severe symptoms including anaphylaxis, cardiovascular collapse, and death. We reported on a patient with arterial thrombotic occlusion and...
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Effects of Emollient Containing Bee Venom on Atopic Dermatitis: A Double-Blinded, Randomized, Base-Controlled, Multicenter Study of 136 Patients

You CE, Moon SH, Lee KH, Kim KH, Park CW, Seo SJ, Cho SH

BACKGROUND: Atopic dermatitis (AD) is a common, complex disease that follows a chronic relapsing course and significantly affects the quality of life of patients. Skin barrier dysfunction and inflammatory processes...
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Acute lung injury after bee sting acupuncture

Chae WY, Kim SH, Lee YH, Lee BH, Lee JH, Woo JJ

Bee stings can cause severe adverse reactions. There have been no cases of acute lung injury induced by bee sting acupuncture. We report a case of a 52-year-old male who...
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A Case of Steven-Johnson Syndrome after Live Bee Acupuncture (Bong-Chim)

Seol YJ, Lee TK, Park SJ, Ko SU, Kim KH, Jang AS

Bee stings can cause various skin reactions that usually resolve over several days; however, in some patients the venom acts as an allergen, causing a severe immunological response such as...
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Serum sickness reaction with skin involvement induced by bee venom injection therapy

Seo HJ, Lee J

Bee venom injection therapy is an alternative treatment sometimes used for chronic inflammatory diseases, including rheumatoid arthritis and multiple sclerosis, to reduce pain. Several chemical components of bee venom have...
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Melittin Ameliorates the Inflammation of Organs in an Amyotrophic Lateral Sclerosis Animal Model

Lee SH, Choi SM, Yang EJ

Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disorder characterized by a selective loss of motor neurons in the spinal cord, brainstem, and motor cortex, leading to weakness of...
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