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Establishment of a chronic obstructive pulmonary disease mouse model based on the elapsed time after LPS intranasal instillation

Lee SY, Cho JH, Cho SS, Bae CS, Kim GY, Park DH

Chronic obstructive pulmonary disease (COPD) was the 3rd leading cause of death in 2012 worldwide. It is particularly severe in the elderly, who are at risk of death by coughing,...
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Alteration of Akt, p-Akt, ERK, and p-ERK Proteins Expression in the Kidney of Hypokalemic Rat

Bae CS, Cho HJ, Ahn KY

Hypokalemia causes metabolic alkalosis and morphological changes of the kidney. K⁺ balance is regulated not only by ion channels or pump gene, but also by various genes including NF-E2-related factor...
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Safety of 8-weeks oral administration of Arctium lappa L.

Bok SH, Cho SS, Bae CS, Park DH, Park KM

Recently, worldwide dietary reference intakes have been considered an important guideline for public health. Some governments and the World Health Organization (WHO) provide guidelines concerning dietary intake. Although an ingredient...
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NADPH Oxidase Mediates β-Amyloid Peptide-Induced Neuronal Death in Mouse Cortical Cultures

Chay KO, Nam Koong , Hwang S, Kim JK, Bae CS

β-Amyloid peptide (Aβ) is the main component of senile plaques in patients with Alzheimer's disease, and is known to be a main pathogenic factor of the disease. Recent evidence indicates...
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Effects of mesenchymal stem cells treated with BMP-2 and VEGF on regeneration of large bone defects

Kim JK, Kim SE, Shim KM, Bae CS, Choi SH, Kang SS

  • KMID: 2168985
  • J Biomed Res.
  • 2014 Mar;15(1):24-31.
This study evaluated the possibility of clinical application using matrigel-based bioceramic/polymer scaffolds treated with bone morphogenetic protein, angiogenic factor, and mesenchymal stem cells (MSCs) for new bone formation. In the...
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Efficacy of alcohol-free cetylpyridinium chloride on periodontal disease in beagle dogs via drinking water additive and oral gel

Kim JK, Kim SE, Bae CS, Shim KM, Choi SH, Jeong SJ, Kang SS

  • KMID: 2055094
  • J Biomed Res.
  • 2013 Mar;14(1):35-39.
This study was conducted in order to examine the effects of alcohol-free cetylpyridinium chloride drinking water additive and oral gel on clinical parameters related to periodontal disease in beagle dogs....
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Spermatotoxic effects of alpha-chlorohydrin in rats

Kim SH, Lee IC, Lim JH, Moon C, Bae CS, Kim SH, Shin DH, Kim HC, Kim JC

  • KMID: 2312087
  • Lab Anim Res.
  • 2012 Mar;28(1):11-16.
This study was conducted to investigate the potential effects of alpha-chlorohydrin (ACH) on epididymal function and antioxidant system in male rats. The test chemical was administered to male rats by...
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Fast neutron irradiation deteriorates hippocampus-related memory ability in adult mice

Yang M, Kim H, Kim J, Kim SH, Kim JC, Bae CS, Kim JS, Shin T, Moon C

Object recognition memory and contextual fear conditioning task performance in adult C57BL/6 mice exposed to cranial fast neutron irradiation (0.8 Gy) were examined to evaluate hippocampus-related behavioral dysfunction following acute...
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Innervated Cross-Finger Pulp Flap for Reconstruction of the Fingertip

Lee NH, Pae WS, Roh SG, Oh KJ, Bae CS, Yang KM

BACKGROUND: Fingertip injuries involving subtotal or total loss of the digital pulp are common types of hand injuries and require reconstruction that is able to provide stable padding and sensory...
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Necrotizing Fasciitis of Nose Skin Following Herpes Zoster

Pae WS, Bae CS, Roh SG, Lee NH, Yang KM

PURPOSE: Varicella-zoster virus (VZV) infection is a common childhood disease. However, old and immune compromised patients are also at risk. Necrotizing fasciitis is a life threatening infection of the subcutaneous...
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Histologic comparison of polycystic ovary syndrome induced by estradiol valerate and letrozole

Lim SC, Jeong MJ, Kim SE, Kim SH, Kim SC, Seo SY, Kim T, Kang SS, Bae CS

OBJECTIVE: To compare ovarian morphology of the estradiol valerate (EV)- and the letrozole (LE)-induced polycystic ovary syndrome (PCOS) in rat models. METHODS: EV were injected (IM) to 10 Sprague-Dawley rats and...
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Enhanced Expression of Carbonic anhydrase II in Hypokalemic Rat Kidney

Lee YC, Jung C, Nam KI, Lee SW, Bae CS, Kim BY, Park SS, Ahn KY

  • KMID: 1982475
  • Korean J Phys Anthropol.
  • 2011 Mar;24(1):57-66.
A number of acid-base or electrolyte disorders are associated with decreased or increased HCO3- reabsorption in the renal tubules. The present study was to examine the alterations of expression and...
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Expression and Cellular Localization of Psx Gene in Rat Placenta

Choi EH, Jung C, Nam KI, Lee SW, Bae CS, Kim BY, Park SS, Ahn KY

  • KMID: 1982474
  • Korean J Phys Anthropol.
  • 2011 Mar;24(1):51-56.
Homeobox genes seem to play critical roles in regulating morphogenesis, patterning, organogenesis, and differentiation. They have the conserved sequence that codes the DNA-binding domain called homeodomain. The expression and cellular...
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Effects of Pilocarpine-induced Seizures on the Neuronal Cell Death, Mossy Fiber Sprouting and Neurogensis in the Hippocampus of Mice

Lee SH, Kook JH, Hwang S, Kim JK, Bae CS

  • KMID: 1449617
  • Korean J Phys Anthropol.
  • 2011 Dec;24(4):225-235.
Present study was performed to delineate the inter-relationship among neuronal death, mossy fiber sprouting (MFS) and neurogenesis in hippocampal formation of pilocarpine-treated mice. Status epilepticus was induced by intraperitoneal administration of...
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The effect of pomegranate on postmenopausal syndrome in ovariectomized rats

Ahn KH, Yi KW, Park HT, Shin JH, Hur JY, Kim YT, Kim SH, Lee KW, Bae CS, Kim T

OBJECTIVE: To determine whether or not pomegranate extract can affect postmenopausal syndrome in ovariectomized rats. METHODS: Seventy-nine female Sprague-Dawley rats were used: A, no intervention; B, sham operation and distilled water;...
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The Effect of Pomegranate on Depression, Anxiety, and Food Intake in Ovariectomized Rats

Ahn KH, Yi KW, Park HT, Shin JH, Hur JY, Kim YT, Kim SH, Lee KW, Kim SH, Bae CS, Kim T

  • KMID: 1853325
  • J Korean Soc Menopause.
  • 2010 Apr;16(1):39-45.
OBJECTIVES: To determine whether or not pomegranate extract can affect depression, anxiety, and food intake in ovariectomized rats. METHODS: Seventy-nine female Sprague-Dawley rats were divided into six groups: A, no operation...
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Neuroprotection by Valproic Acid in Mouse Models of Permanent and Transient Focal Cerebral Ischemia

Qian YR, Lee MJ, Hwang S, Kook JH, Kim JK, Bae CS

Valproic acid (VPA) is a well-known anti-epileptic and mood stabilizing drug. A growing number of reports demonstrate that VPA is neuroprotective against various insults. Despite intensive efforts to develop new...
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HOXB13 is co-localized with androgen receptor to suppress androgen-stimulated prostate-specific antigen expression

Kim SD, Park RY, Kim YR, Kim IJ, Kang TW, Nam KI, Ahn KY, Bae CS, Kim BY, Park SS, Jung C

During the prostate cancer (PCa) development and its progression into hormone independency, androgen receptor (AR) signals play a central role by triggering the regulation of target genes, including prostate-specific antigen....
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Alterations of Aquaporin mRNA and Protein Expression in Hypokalemic Rat Kidney

Kim DS, Lee CB, Bae CS, Kim BY, Park SS, Ahn KY

  • KMID: 1472505
  • Korean J Anat.
  • 2009 Mar;42(1):31-39.
There has been a general agreement that potassium depletion causes metabolic alkalosis and substantial morphological changes in kidney structure, and is associated with renal functional abnormalities, including a decrease in...
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Immunohistochemical Localizaion of Carbonic Anhydrase Isozymes IV and IX in Rat Salivary Gland

Cho TY, Lee SE, Nam KI, Jung C, Ahn KY, Bae CS, Kim BY, Park SS

  • KMID: 1472485
  • Korean J Anat.
  • 2009 Dec;42(4):325-333.
This study presents distribution of carbonic anhydrase (CA) isozymes IV and IX, membrane associated forms, and CA I and II, cytoplasmic forms, in rat parotid and submandibular glands using Western...
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