- Purification and cloning of glyoxalase II from rat liver
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Cho MY, Bae CD, Park JB, Lee TH
- KMID: 754988
- Exp Mol Med.
- 1998 Mar;30(1):53-57.
Glyoxalase (GLO) II, which is a component of GLO system and catalyze the conversion of S-lactoyl-glutathione to D-lactate, was purified 1488 fold from rat liver by two steps of Affigel blue and... -
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- Post-transcriptional control of c-erb B-2 overexpression in stomach cancer cells
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Bae CD, Juhnn YS, Park JB
- KMID: 755111
- Exp Mol Med.
- 2001 Mar;33(1):15-19.
The growth factor receptor oncogene, c-erb B-2, is frequently overexpressed in the adenocarcinomas of breast, ovary, lung and stomach. Although the mechanism of erb B-2 overexpression is thought as the... -
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- Activation of JNK and p38 in rat hippocampus after kainic acid induced seizure
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Jeon SH, Kim YS, Bae CD, Park JB
- KMID: 755104
- Exp Mol Med.
- 2000 Dec;32(4):227-230.
Kainic acid, an analogue of glutamate, causes limbic seizures and induces cell death in the rat brain. We examined the activation of MAPK family kinases; ERKs, JNKs and... -
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- CKAP2 phosphorylation by CDK1/cyclinB1 is crucial for maintaining centrosome integrity
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Yoo BH, Kang DS, Park CH, Kang K, Bae CD
- KMID: 2388352
- Exp Mol Med.
- 2017 Jul;49(7):e354.
- doi: 10.1038/emm.2017.92
Previously, we have reported that CKAP2 is involved in the maintenance of centrosome integrity, thus allowing for proper mitosis in primary hepatocytes. To understand this biological process, we identified the... -
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- The mechanism of c-erbB-2 gene product increase in stomach cancer cell lines
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Bae CD, Park SE, Seong YS, Kim SW, park JB, Park JG
- KMID: 1421967
- J Korean Med Sci.
- 1993 Apr;8(2):153-159.
- doi: 10.3346/jkms.1993.8.2.153
c-erbB-2 oncogene encodes a growth factor receptor whose amino acid sequence has extensive homology with human epidermal growth factor receptor. It is frequently overexpressed in human breast, ovary, lung, and... -
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- Calpain inhibitors reduce the cornified cell envelope formation by inhibiting proteolytic processing of transglutaminase 1
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Kim SY, Bae CD
- KMID: 755018
- Exp Mol Med.
- 1998 Dec;30(4):257-262.
Calpain I (mu-calpain) and II (m-calpain) are well known calcium-activated neutral cysteine proteases. Many reports have shown that activation of calpain is related to cataract formation, neuronal degeneration, blood clotting, ... -
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- Characterization of mitosis-specific phosphorylation of tumor-associated microtubule-associated protein
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Hong KU, Kim HJ, Bae CD, Park J
- KMID: 1122284
- Exp Mol Med.
- 2009 Nov;41(11):832-840.
- doi: 10.3858/emm.2009.41.11.089
Tumor-associated microtubule-associated protein (TMAP), also known as cytoskeleton associated protein 2 (CKAP2), has been recently shown to be involved in the assembly and maintenance of mitotic spindle and also plays... -
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- Expression of the EGF Receptor Gene Family in Gastric Cancer
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Lee HW, Choi EY, Bae CD, Ryu BY, Yu HJ, Yang HK, Kim JP
- KMID: 2206406
- J Korean Surg Soc.
- 1998 Oct;55(4):498-513.
Growth factor receptors play critical roles in the regulation of normal growth and developement. Some of these molecules have been implicated in the neoplastic process as well. In this study,... -
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- Multi-facet expressions of adenylate cyclase isoforms in B16-F10 melanoma cells differentiated by forskolin treatment
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Cho DH, Bae CD, Juhnn YS
- KMID: 755106
- Exp Mol Med.
- 2000 Dec;32(4):235-242.
The terminal differentiation of malignant melanoma cells is known to be induced by activating cAMP signaling pathway with alpha-MSH or cAMP analogues. However, sustained activation of cAMP signaling... -
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- Retainment of membrane binding capacity of non-palmitoylated Gs alpha mutants expressed in COS-1 cells
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Yang JM, Cho CH, Bae CD, Juhnn YS
- KMID: 755014
- Exp Mol Med.
- 1998 Dec;30(4):235-239.
Heterotrimeric guanine nucleotide binding regulatory proteins (G proteins) transduce extracellular signals into intracellular signals by coupling receptors and effectors. Because most of the G protein-coupled receptors are integral proteins, the... -
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- PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity
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Lee SJ, Lee JR, Hah HS, Kim YH, Ahn JH, Bae CD, Yang JM, Hahn MJ
- KMID: 756067
- Exp Mol Med.
- 2007 Aug;39(4):450-457.
Zinc finger protein 133 (ZNF133) is composed of a Kruppel-associated box (KRAB) domain and 14 contiguous zinc finger motifs. ZNF133 is regarded as a transcriptional repressor because the KRAB domain... -
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- Expression of EGF Receptor Family Genes and Proteins in Gastric Cacner ( EGFR , c-erbB-2 , c-erbB-3 , c-erbB-4 )
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Lee HW, Choi EY, Bae CD, Yang HK, Kim WH, Kim JP
- KMID: 2175325
- J Korean Cancer Assoc.
- 1998 Oct;30(5):853-868.
PURPOSE: to evaluate the relationship between the expression of EGF receptor gene family and clinico-pathologic parameters. MATERIALS AND METHODS: We compared adenocarcinoma tissue with normal mucosa obtained from same patients... -
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- Transient phosphorylation of tumor associated microtubule associated protein (TMAP)/cytoskeleton associated protein 2 (CKAP2) at Thr-596 during early phases of mitosis
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Hong KU, Choi YB, Lee JH, Kim HJ, Kwon HR, Seong YS, Kim HT, Park J, Bae CD, Hong KM
- KMID: 1094117
- Exp Mol Med.
- 2008 Aug;40(4):377-386.
- doi: 10.3858/emm.2008.40.4.377
Tumor associated microtubule associated protein (TMAP), also known as cytoskeleton associated protein 2 (CKAP2) is a mitotic spindle-associated protein whose expression is cell cycle-regulated and also frequently deregulated in cancer... -
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- AMPA, not NMDA, activates RhoA GTPases and subsequetly phosphorylates moesin
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Kim SJ, Jeon S, Shin EY, Kim EG, Park J, Bae CD
- KMID: 755672
- Exp Mol Med.
- 2004 Feb;36(1):98-102.
Glutamate induced rapid phosphorylation of moesin, one of ERM family proteins involved in the ligation of membrane to actin cytoskeleton, in rat hippocampal cells (JBC, 277:16576-16584, 2002). However, the identity... -
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- Downregulation of regenerating islet-derived 3 alpha (REG3A) in primary human gastric adenocarcinomas
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Choi B, Suh Y, Kim WH, Christa L, Park J, Bae CD
- KMID: 1091074
- Exp Mol Med.
- 2007 Dec;39(6):796-804.
Gastric carcinoma is considered to be one of the most prevalent cancers worldwide. We have performed differential-display polymerase chain reaction (DD-PCR) in order to compare the gene expression profile of... -
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- Protective Effects of Gabapentin on Allodynia and alpha2delta1-Subunit of Voltage-dependent Calcium Channel in Spinal Nerve-Ligated Rats
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Hahm TS, Ahn HJ, Bae CD, Kim HS, Lim SW, Cho HS, Lee SM, Sim WS, Kim JA, Gwak MS, Choi SJ
- KMID: 1794421
- J Korean Med Sci.
- 2009 Feb;24(1):146-151.
- doi: 10.3346/jkms.2009.24.1.146
This study was designed to determine whether early gabapentin treatment has a protective analgesic effect on neuropathic pain and compared its effect to the late treatment in a rat neuropathic... -
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- Clinical implications of proliferation activity in T1 or T2 male gastric cancer patients
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Kim YW, Eom BW, Kook MC, Kim HS, Kim MK, Hwang HL, Chandra V, Poojan S, Song Y, Koh JS, Bae CD, Ro J, Hong KM
- KMID: 2359880
- Exp Mol Med.
- 2015 Nov;47(11):e193.
- doi: 10.1038/emm.2015.79
Proliferation activity has already been established as a prognostic marker or as a marker for anticancer drug sensitivity. In gastric cancer, however, the prognostic significance of proliferation activity is still... -
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