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Capecitabine and temozolomide for metastatic intermediate to high-grade pancreatic neuroendocrine neoplasm: a single center experience

Douangprachanh S, Joo HJ, Park HM, Han N, Jang HY, Koh YH, Kim TH, Han SS, Park SJ, Lee WJ, Woo SM, Chun JW

Background/Aims: The combination of capecitabine and temozolomide (CAPTEM) is one of the treatment options for metastatic pancreatic neuroendocrine neoplasms (pNENs). This study aims to evaluate the efficacy of CAPTEM in...
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Structural Model of Hospital Nurses’ Compliance with Antineoplastic Drugs Safety Management Guidelines Based on Theory of Planned Behavior

Roh M, Kim O

Purpose: This study aims to determine a hypothetical model concerning factors affecting hospital nurses’compliance with the guidelines of antineoplastic drugs safety management based on the theory of planned behavior. Methods: Data...
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Factors Influencing Compliance with Safe Handling Requirements of Antineoplastic Agents by Nurses in a Tertiary Hospital

Lee SG, Choi SY

Purpose: The research aimed to identify leading factors that affect a nurse’s compliance with safe handling in the use of antineoplastic agents. Methods: Data were collected from 114 nurses working...
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Endoscopic ultrasound-guided ablation of pancreatic cystic lesions

Choi JH, Lee SH

Endoscopic ultrasound (EUS)-guided ablation procedures are emerging as minimally invasive therapeutic methods that address unmet needs in treatment methods for pancreatic cystic lesions (PCLs). Several studies have been published on...
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Factors Influencing the Implementation of Anticancer Drug Safety Management Guidelines for Nurses

Min DJ, Kim MR

Purpose: This descriptive survey study was conducted to determine the degree of implementation of anticancer drug safety management guidelines by nurses handling anticancer drugs, safety motivation, safety control, ward safety...
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Disparities in Access to Systemic Treatment for Breast Cancer in Thailand and Major Asian Territories

Ithimakin S, Parinyanitikul N, Kim SB, Yap YS, Tsang J, Soong IS, Ozaki Y, Ohno S, Ono M, Chan JJ, Cheng HCS, Dejthevaporn T, oboBAC

Purpose: Breast cancer (BC) treatment has shifted from chemotherapy to targeted therapy. Several targeted agents have demonstrated an improvement in survival. Given that national healthcare resources were correlated with the cancer...
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Prevalence of malnourishment and predictive factors associated with the nutritional status of gynecologic cancer patients undergoing chemotherapy: a cross-sectional analysis

Sanguanwongthong K, Suprasert P

Objective To investigate the prevalence and predictive factors of malnourishment in patients with gynecologic cancer during chemotherapy. Methods A total of 101 patients treated with chemotherapy between April 2020 and February...
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Desensitization for the prevention of drug hypersensitivity reactions

Kang SY, Seo J, Kang HR

Drug desensitization is the temporary induction of tolerance to a sensitized drug by administering slow increments of the drug, starting from a very small amount to a full therapeutic dose....
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Usefulness of cyclic thermal therapy and red blood cell scintigraphy in patients with chemotherapy-induced peripheral neuropathy

Kim M, Kim EM, Oh PS, Lim ST, Sohn MH, Song EK, Park KU, Kim JY, Won KS, Jeong HJ

Background: Pharmacological and non-pharmacological therapies have been used to treat patients with chemotherapy-induced peripheral neuropathy (CIPN). However, the effect of therapies in cancer patients has yet to be investigated comprehensively....
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Clinical Scales for Diabetic Neuropathy and Chemotherapy-induced Neuropathy

Oh J

Diabetic neuropathy and chemotherapy-induced peripheral neuropathy are complex disorders affecting different nerve fiber group and remain as major source of morbidity and decreased quality of life of the patients. Given...
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Effect of Combining EGFR Tyrosine Kinase Inhibitors and Cytotoxic Agents on Cholangiocarcinoma Cells

Boonsri B, Yacqub-Usman K, Thintharua P, Myint KZ, Sae-Lao T, Collier P, Suriyonplengsaeng C, Larbcharoensub N, Balasubramanian B, Venkatraman S, Egbuniwe IU, Gomez D, Mukherjee A, Kumkate S, Janvilisri T, Zaitoun AM, Kuakpaetoon T, Tohtong R, Grabowska AM, Bates DO, Wongprasert K

Purpose The potential of members of the epidermal growth factor receptor (ErbB) family as drug targets in cholangiocarcinoma (CCA) has not been extensively addressed. Although phase III clinical trials showed...
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Factors Influencing Compliance with Safe Handling of Antineoplastic Agents Among Clinical Nurses

Lee H, Song JE, Ahn JA, Boo S

Purpose: This study aimed to investigate the levels of compliance with safe handling of antineoplastic agents, time pressure, knowledge of safe handling of antineoplastic agents, and workplace safety climate, and...
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Recent Advances in the Development of TGF-β Signaling Inhibitors for Anticancer Therapy

Lee HJ

TGF-β is a multifunctional cytokine that plays an important role in both physiologic and pathologic processes, including cancer. Importantly, TGF-β has a dual role in tumorigenesis, acting as a tumor...
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Effect of Podophyllotoxin Conjugated Stearic Acid Grafted Chitosan Oligosaccharide Micelle on Human Glioma Cells

Wang GH, Shen HP, Huang X, Jiang XH, Jin CS, Chu ZM

Objective : To study the physiochemical characteristics of podophyllotoxin (PPT) conjugated stearic acid grafted chitosan oligosaccharide micelle (PPT-CSO-SA), and evaluate the ability of the potential antineoplastic effects against glioma cells. Methods...
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Change in Estradiol Levels among Premenopausal Patients with Breast Cancer Treated Using Leuprolide Acetate 11.25 Milligrams 3-Month Depot and Tamoxifen

Lee Yj, Wu ZY, Kim Hj, Lee JW, Chung IY, Kim J, Lee SB, Son BH, Kim SB, Jung JH, Gong G, Ahn SH, Ko B

The combination of luteinizing hormone-releasing hormone analogs (LHRHa) with tamoxifen is used as a standard postoperative adjuvant therapy in patients with hormone receptor-positive/premenopausal breast cancer. Long-acting LHRHa formulations offer advantages...
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Determinants of neoadjuvant chemotherapy use in muscle-invasive bladder cancer

Carvalho FL, Zeymo A, Egan J, Kelly CH, Zheng C, Lynch JH, Hwang J, Stamatakis L, Krasnow RE, Kowalczyk KJ

Purpose: Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) is standard of care for muscleinvasive bladder cancer (MIBC). However, NAC is used in less than 20% of patients with...
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Impressive effect of cisplatin monotherapy on a patient with heavily pretreated triple-negative breast cancer with poor performance

Baek DW, Park JY, Lee SJ, Chae YS

Systemic therapy for metastatic triple-negative breast cancer (TNBC) still remains challenging because there are no targeted agents or endocrine therapies currently available. The present case report documents the successful use...
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Baseline Serum Interleukin-6 Levels Predict the Response of Patients with Advanced Non-small Cell Lung Cancer to PD-1/PD-L1 Inhibitors

Kang DH, Park CK, Chung C, Oh IJ, Kim YC, Park D, Kim J, Kwon GC, Kwon I, Sun P, Shin EC, Lee JE

Although various studies on predictive markers in the use of PD-1/PD-L1 inhibitors are in progress, only PD-L1 expression levels in tumor tissues are currently used. In the present study, we...
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The Use of Gonadotropin-Releasing Hormone Agonist Does Not Affect the Development of Cardiovascular Disease in Prostate Cancer Patients: a Nationwide Population-Based Cohort Study

Shim M, Bang WJ, Oh CY, Lee YS, Jeon SS, Ahn H, Ju YS, Cho JS

BACKGROUND: The objective of this study was to investigate whether androgen deprivation therapy (ADT) with gonadotropin-releasing hormone agonist (GnRHa) in prostate cancer (Pca) patients is associated with cardiovascular disease in...
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Optimal Management of Chemotherapy-related Adverse Events

Jung MK

This review article deals with the optimal management of chemotherapy-related adverse events which are the nausea, vomiting, diarrhea, neutropenia, peripheral polyneuropathy. Recent literatures are reviewed and pathogenetic mechanism and management...
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