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Effects of growth hormone on glucose metabolism and insulin resistance in human

Kim SH, Park MJ

Growth hormone (GH) is important for promotion of somatic growth and the regulation of substrate metabolism. Metabolic action of GH occurs in multiple tissues including the liver, muscle, fat and...
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Delayed diagnosis of pituitary stalk interruption syndrome with severe recurrent hyponatremia caused by adrenal insufficiency

Jang KM, Ko CW

Pituitary stalk interruption syndrome (PSIS) involves the occurrence of a thin or absent pituitary stalk, hypoplasia of the adenohypophysis, and ectopic neurohypophysis. Diagnosis is confirmed using magnetic resonance imaging. Patients...
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Novel genetic cause of idiopathic short stature

Kang MJ

Traditionally, the growth hormone – insulin-like growth factor I (GH – IGF-I) axis is the most important signaling pathway in linear growth, and defects in this axis present as growth...
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Clinical manifestations of Rathke’s cleft cysts and their natural progression during 2 years in children and adolescents

Jung JE, Jin J, Jung MK, Kwon A, Chae HW, Kim DH, Kim HS

PURPOSE: Rathke’s cleft cyst (RCC) is an asymptomatic benign lesion. With increased interest in pediatric endocrinology, the prevalence of RCCs in children is also increasing. However, the clinical relevance and...
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Impact of targeted education on managing warning and error signals by children and adolescents with type 1 diabetes using the Accu-Chek Combo Insulin Pump System

Deeb A, Qahtani NA, Ali AA, Akle M

PURPOSE: Insulin pumps are widely used in diabetes. They are equipped with safety alarms to alert users. Pump manuals contain alarm codes and how to troubleshoot them. However, these manuals...
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A rare case of multiple pituitary adenomas in an adolescent Cushing disease presenting as a vertebral compression fracture

Song JY, Mun SJ, Sung SK, Hwang JY, Baik SK, Kim JY, Cheon CK, Kim SY, Kim YM

Cushing disease in children and adolescents, especially with multiple pituitary adenomas (MPAs), is very rare. We report 17-year-old boy with MPAs. He presented with a vertebral compression fracture, weight gain,...
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Insulin resistance and bone age advancement in girls with central precocious puberty

Hur JH, Park S, Jung MK, Kang SJ, Kwon A, Chae HW, Kim HS, Kim DH

PURPOSE: Precocious puberty has significantly increased recently. While obesity is associated with puberty timing, the relationship between obesity and central precocious puberty (CPP) remains controversial. The purpose of this study...
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Diurnal variation of gonadotropin levels in girls with early stages of puberty

Kang YS, Yoo DY, Chung IH, Yoo EG

PURPOSE: Pubertal gonadotropin secretion shows circadian pattern and the luteinizing hormone (LH) levels tend to rise in later stages of puberty in girls. We studied the usefulness of basal LH...
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The triglyceride-to-high density lipoprotein cholesterol ratio in overweight Korean children and adolescents

Yoo DY, Kang YS, Kwon EB, Yoo EG

PURPOSE: The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio has recently been reported as a biomarker of cardiometabolic risk in obese children and adolescents. The purpose of this study is to describe...
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Nonalcoholic fatty liver disease in long-term survivors of childhood-onset craniopharyngioma

Jung SY, Lee YJ, Lee HJ, Lee YA, Moon JS, Ko JS, Yang SW, Shin CH

PURPOSE: Hypothalamic obesity in childhood-onset (CO-) craniopharyngioma patients may predispose to nonalcoholic fatty liver disease (NAFLD). This study reviewed the characteristics of NAFLD associated with CO-craniopharyngioma. METHODS: This study retrospectively reviewed...
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An atypical case of Noonan syndrome with KRAS mutation diagnosed by targeted exome sequencing

Kim J, Cho SY, Yang A, Jang JH, Choi Y, Lee JE, Jin DK

Noonan syndrome (NS) is a genetic disorder caused by autosomal dominant inheritance and is characterized by a distinctive facial appearance, short stature, chest deformity, and congenital heart disease. In individuals...
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