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Pathophysiology and clinical characteristics of hypothalamic obesity in children and adolescents

Kim JH, Choi JH

The hypothalamus plays a key role in the regulation of body weight by balancing the intake of food, energy expenditure, and body fat stores, as evidenced by the fact that...
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Changes of antithroglobulin antibody in children with congenital hypothyroidism

Cho EM, Kim UH, Choi BH, Ko CW

PURPOSE: It has been reported that antithroglobulin (anti-TG) antibody is increased in the sera of both children with transient congenital hypothyroidism and their mothers. And transplacental transport of thyroid autoantibody...
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Reduced male fertility in childhood cancer survivors

Lee SH, Shin CH

With advances in cancer treatment, more pediatric cancer patients have increased their life expectancy. Because cancer-related therapy causes various physical and psychological problems, many male survivors experience later problems with...
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Serum glycated albumin as a new glycemic marker in pediatric diabetes

Lee JW, Kim HJ, Kwon YS, Jun YH, Kim SK, Choi JW, Lee JE

PURPOSE: Serum glycated albumin (GA) has been recently used as another glycemic marker that reflects shorter term glycemic control than glycated hemoglobin (HbA1c). Insulin secretory function and glycemic fluctuation might...
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Nongoitrous autoimmune thyroiditis with facial palsy

Lee HJ, Kim JK

We report a case of severe hypothyroidism with nongoitrous, autoimmune thyroiditis and pituitary hyperplasia in a 13-year-old boy, who presented with sudden palsy on the left side of his face....
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The difference in serum alkaline phosphatase levels between girls with precocious puberty and those with normal puberty

Jwa HJ, Yang SI, Lim HH

PURPOSE: Serum alkaline phosphatase (ALP) level is the most valid marker of bone formation. Precocious puberty (PP) in girls is characterized by early growth acceleration. The aim of this study...
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Boys with precocious or early puberty: incidence of pathological brain magnetic resonance imaging findings and factors related to newly developed brain lesions

Choi KH, Chung SJ, Kang MJ, Yoon JY, Lee JE, Lee YA, Shin CH, Yang SW

PURPOSE: Brain magnetic resonance imaging (MRI) findings and factors predictive of pathological brain lesions in boys with precocious puberty (PP) or early puberty (EP) were investigated. METHODS: Sixty-one boys with PP...
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Basal luteinizing hormone and follicular stimulating hormone: is it sufficient for the diagnosis of precocious puberty in girls?

Lee DS, Ryoo NY, Lee SH, Kim S, Kim JH

PURPOSE: A gonadotropin-releasing hormone stimulation test (GnRHST) is the gold standard in diagnosing central precocious puberty (CPP). The aim of this study was to investigate the diagnostic accuracy of basal...
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Factors that predict a positive response on gonadotropin-releasing hormone stimulation test for diagnosing central precocious puberty in girls

Suh J, Choi MH, Kwon AR, Kim YJ, Jeong JW, Ahn JM, Chae HW, Kim DH, Kim HS

PURPOSE: The rapid increase in the incidence of precocious puberty in Korea has clinical and social significance. Gonadotropin-releasing hormone (GnRH) stimulation test is required to diagnose central precocious puberty (CPP),...
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Multicenter clinical trial of leuprolide acetate depot (Luphere depot 3.75 mg) for efficacy and safety in girls with central precocious puberty

Kim YJ, Lee HS, Lee YJ, Lim JS, Kim SY, Kim EY, Jin DK, Hwang IT, Hwang JS

PURPOSE: We evaluated the efficacy, safety and psychological aspect of monthly administrations of the gonadotropin-releasing hormone agonists (GnRHa), leuprolide acetate depot (Luphere depot 3.75 mg), in patients with precocious puberty. METHODS:...
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