- Histopathological and biochemical findings of congenital copper deficiency: are these similar to those of caprine arthritis-encephalitis?
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Ozkul IA, Alcigir G, Sepici-Dincel A, Yonguc AD, Akcora A, Turkaslan
- KMID: 1365011
- J Vet Sci.
- 2012 Mar;13(1):107-109.
- doi: 10.4142/jvs.2012.13.1.107
This study was done after identifying animals with a twisted carpal joint in goat herd. These included a kid goat walking on its articulus carpii and a newborn goat with... -
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- Therapeutic Window for Cycloheximide Treatment after Hypoxic-Ischemic Brain Injury in Neonatal Rats
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Park WS, Sung DK, Kang S, Koo SH, Kim YJ, Lee JH, Chang YS, Lee M
- KMID: 1778434
- J Korean Med Sci.
- 2006 Jun;21(3):490-494.
- doi: 10.3346/jkms.2006.21.3.490
We have previously shown that cycloheximide significantly inhibited apoptosis, and reduced ensuing cerebral infarction in a newborn rat model of cerebral hypoxiaischemia. This study was performed to determine the therapeutic... -
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- Evidence for adverse effect of perinatal glucocorticoid use on the developing brain
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Chang YP
- KMID: 1702648
- Korean J Pediatr.
- 2014 Mar;57(3):101-109.
- doi: 10.3345/kjp.2014.57.3.101
The use of glucocorticoids (GCs) in the perinatal period is suspected of being associated with adverse effects on long-term neurodevelopmental outcomes for preterm infants. Repeated administration of antenatal GCs to... -
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- Effect of hypothermia on brain cell membrane function and energy metabolism after transient global hypoxia-ischemia in the newborn piglet
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Park WS, Chang YS, Lee MH
- KMID: 1129907
- J Korean Med Sci.
- 2001 Jun;16(3):335-341.
- doi: 10.3346/jkms.2001.16.3.335
This study was done to determine the effects of hypothermia on brain cell membrane function and energy metabolism after transient hypoxia-ischemia (HI) in the newborn piglet. Cerebral HI was induced... -
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- Detrimental Effects of N(w)-nitro-L-arginine Methyl Ester (L-NAME) in Experimental Escherichia coli Sepsis in the Newborn Piglet
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Kim SS, Hwang JH, Choi CW, Shim JW, Chang YS, Park WS, Oh CK
- KMID: 1130031
- J Korean Med Sci.
- 2003 Oct;18(5):637-640.
- doi: 10.3346/jkms.2003.18.5.637
The role of nitric oxide during neonatal sepsis is complex. We tested the hypothesis that nonselective inhibition of nitric oxide synthase with N(w) -nitro-L-arginine methyl ester (L-NAME) is detrimental during... -
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- Effects of Perfluorocarbon Associated High Frequency Oscillatory Ventilation on Hemodynamics and Gas Exchange in the Newborn Piglets with Respiratory Distress
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Choi CW, Koh SY, Chang YS, Park WS
- KMID: 1130035
- J Korean Med Sci.
- 2003 Oct;18(5):663-668.
- doi: 10.3346/jkms.2003.18.5.663
We sought to know whether there is a further improvement in gas exchange when partial liquid ventilation (PLV) is added to high-frequency oscillatory ventilation (HFOV) in a piglet model of... -
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- A Quantitative Morphologic Analysis of the Rat's Liver in the Postnatal Period
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Pak SY
- KMID: 687667
- Yonsei Med J.
- 1972 Dec;13(1):60-66.
- doi: 10.3349/ymj.1972.13.1.60
Quantitative morphological or histological features within the hepatic acinus were studied to determine the proportional difference of tissue components by regions or zones in different ages in the male albino... -
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- Neuroprotective Effect of Cycloheximide on Hypoxic-Ischemic Brain Injury in Neonatal Rats
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Park WS, Sung DK, Kang S, Koo SH, Kim YJ, Lee JH, Chang YS, Lee M
- KMID: 1781846
- J Korean Med Sci.
- 2006 Apr;21(2):337-341.
- doi: 10.3346/jkms.2006.21.2.337
This study was done to determine the neuroprotective effect of cycloheximide on neonatal hypoxic-ischemic brain injury. Seven day-old newborn rat pups were subjected to 90 min of 8% oxygen following... -
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- Effects of Dopamine Infusion on Cerebral Blood Flow, Brain Cell Membrane Function and Energy Metabolism in Experimental Escherichia coli Meningitis in the Newborn Piglet
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Park WS, Chang YS, Shim JW, Kim MJ, Ko SY, Kim SS, Hwang JH, Choi CW, Lee M
- KMID: 1086746
- J Korean Med Sci.
- 2003 Dec;18(6):869-875.
- doi: 10.3346/jkms.2003.18.6.869
In the present study, we tested whether maintenance of adequate cerebral perfusion pressure (CPP) by pharmacologically preventing systemic hypotension with dopamine infusion would prevent cerebral ischemia and attenuate energy depletion... -
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- Immunohistochemical study of osteopontin in boar testis
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Kim S, Shin T
- KMID: 1089659
- J Vet Sci.
- 2007 Jun;8(2):107-110.
- doi: 10.4142/jvs.2007.8.2.107
The expression of osteopontin (OPN) in boar testis was studied. Western blot analysis detected 66- and 32-kDa OPN immunopositive bands in the testes of adult boars. In postnatal piglets, the... -
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- Pretreatment with N-nitro-L-arginine Methyl Ester Improved Oxygenation After Inhalation of Nitric Oxide in Newborn Piglets with Escherichia coli Pneumonia and Sepsis
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Chang YS, Kang S, Ko SY, Park WS
- KMID: 1713102
- J Korean Med Sci.
- 2006 Dec;21(6):965-972.
- doi: 10.3346/jkms.2006.21.6.965
We evaluated the effects of a combined therapy of pre-blockade endogenous nitric oxide synthase (NOS) with N-nitro-L-arginine methyl ester (L-NAME) and continuous inhaled NO (iNO) on the gas exchange and... -
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- Clival Window Videomicroscopy of Basilar Artery Reactivity in Newborn Piglet
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Kim TY
- KMID: 2067414
- J Korean Neurosurg Soc.
- 1996 Jul;25(7):1344-1351.
This report is the author's in vivo study of basilar artery reactivity to physiologic and pharmacologic stimuli in a newborn animal model. Isoflurane-anesthetized and ventilated piglets(less than 3 days of... -
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- Erythropoietin Attenuates Hyperoxia-Induced Lung Injury by Down-modulating Inflammation in Neonatal Rats
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Lee JH, Sung DK, Koo SH, Shin BK, Hong YS, Son CS, Lee JW, Chang YS, Park WS
- KMID: 1785767
- J Korean Med Sci.
- 2007 Dec;22(6):1042-1047.
- doi: 10.3346/jkms.2007.22.6.1042
This study was done to determine whether recombinant human erythropoietin (rhEPO) treatment could attenuate hyperoxia-induced lung injury, and if so, whether this protective effect is mediated by the down-modulation of... -
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- Protective Effect of Hypoxic Preconditioning on Hypoxic-Ischemic Injured Newborn Rats
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Park HK, Seol IJ, Kim KS
- KMID: 1123451
- J Korean Med Sci.
- 2011 Nov;26(11):1495-1500.
- doi: 10.3346/jkms.2011.26.11.1495
Brief episodes of cerebral hypoxia-ischemia cause transient ischemic tolerance to subsequent ischemic events that are otherwise lethal. This study was conducted to evaluate the protective effect of hypoxic preconditioning on... -
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- Effects of alpha-Phenyl-N-tert-Butyl Nitrone (PBN)on Brain Cell Membrane Function and Energy Metabolism during Transient Global Cerebral Hypoxia-Ischemia and Reoxygenation-Reperfusion in Newborn Piglets
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Choi CW, Hwang JH, Chang YS, Shin SM, Park WS, Lee M
- KMID: 1786821
- J Korean Med Sci.
- 2004 Jun;19(3):413-418.
- doi: 10.3346/jkms.2004.19.3.413
We sought to know whether a free radical spin trap agent, alpha-phenyl-N-tert-butyl nitrone (PBN) influences brain cell membrane function and energy metabolism during and after transient global hypoxia-ischemia (HI) in... -
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- Effects of decreased cerebral perfusion pressure on cerebral hemodynamics, brain cell membrane function and energy metabolism during the early phase of experimental Escherichia coli meningitis in the newborn piglet
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Park WS, Chang YS
- KMID: 648125
- J Korean Med Sci.
- 2000 Apr;15(2):203-210.
- doi: 10.3346/jkms.2000.15.2.203
In this study, we tested the hypothesis that decreased cerebral perfusion pressure (CPP) induces cerebral ischemia and worsen brain damage in neonatal bacterial meningitis. Meningitis was induced by intracisternal injection... -
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- Erythropoietin Attenuates Brain Injury, Subventricular Zone Expansion, and Sensorimotor Deficits in Hypoxic-Ischemic Neonatal Rats
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Kim SS, Lee KH, Sung DK, Shim JW, Kim MJ, Jeon GW, Chang YS, Park WS
- KMID: 1786889
- J Korean Med Sci.
- 2008 Jun;23(3):484-491.
- doi: 10.3346/jkms.2008.23.3.484
The aim of this study was to investigate the effect of erythropoietin (EPO) on histological brain injury, subventricular zone (SVZ) expansion, and sensorimotor function deficits induced by hypoxia-ischemia (HI) in... -
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- Combined Effect of Low-dose Nitric Oxide Gas Inhalation with Partial Liquid Ventilation on Hemodynamics, Pulmonary Function, and Gas Exchange in Acute Lung Injury of Newborn Piglets
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Choi CW, Hwang JH, Chang YS, Park WS
- KMID: 1086737
- J Korean Med Sci.
- 2003 Dec;18(6):813-820.
- doi: 10.3346/jkms.2003.18.6.813
We conducted a randomized animal study to determine whether there is a cumulative effect on hemodynamics, pulmonary function, and gas exchange when low dose nitric oxide (NO) is added to... -
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- Periventricular leukomalacia induced by in utero clamping of pregnant rat aorta in fetal rats
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Chang YS, Sung DK, Kang S, Park SK, Jung YJ, Seo HJ, Choi SH, Park WS
- KMID: 2127995
- Korean J Pediatr.
- 2008 Aug;51(8):874-878.
- doi: 10.3345/kjp.2008.51.8.874
PURPOSE: This study was undertaken to develop an animal model of periventricular leukomalacia (PVL) induced by in utero clamping of pregnant rat aorta in fetal rats. METHODS: A timed pregnanct Sprague-Dawley... -
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- Effects of exposure conditions to footshocks early in life on spontaneous locomotor activity at maturity in rats
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Kim DG, Lee S, Lim JS
- KMID: 711625
- Yonsei Med J.
- 1999 Apr;40(2):124-130.
- doi: 10.3349/ymj.1999.40.2.124
Both genetic and environmental factors are involved in establishing a behavior. An animal study was done to determine the characteristics of interaction between genetic (nature) and environmental (nurture)... -
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