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Suppressive role of vascular endothelial growth factor on intestinal apoptosis in induced necrotizing enterocolitis in rats

Yang HB, Kim HY, Kim SH, Kim Sy

Purpose: Necrotizing enterocolitis (NEC) is a devastating disease that can cause mortality in preterm babies. NEC may develop through an apoptotic pathway that is known to be inhibited by vascular...
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Micropipette tip intubation in rats as a replacement for conventional endotracheal tube intubation

Kim MG, Ryu eH, Lee DM, Park TS, Choi JA

Endotracheal intubation is often necessary in the course of animal experiments, especially in craniofacial surgery. However, endotracheal intubation can be a major burden in this context. The authors performed simple...
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Ablative Outcomes of Various Energy Modes for No-Touch and Peripheral Tumor-Puncturing Radiofrequency Ablation: An Ex Vivo Simulation Study

Cha DI, Lee MW, Song KD, Ko SE, Rhim H

Objective: To compare the outcomes of radiofrequency ablation (RFA) using dual switching monopolar (DSM), switching bipolar (SB), and combined DSM + SB modes at two different interelectrode distances (25 and...
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Quantitative Analysis of Microperfusion in ContrastInduced Nephropathy Using Contrast-Enhanced Ultrasound: An Animal Study

Seo N, Oh H, Oh HJ, Chung YE

Objective: To investigate imaging biomarkers of microperfusion in contrast-induced nephropathy (CIN) using contrastenhanced ultrasound (CEUS). Materials and Methods: The CIN model was fabricated by administering indomethacin (10 mg/kg), L-NAME (15 mg/kg),...
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The effects of optimizing blood inflow in the pedicle on perforator flap survival: A pilot study in a rat model

Olariu R, Moser HL, Lese I, Sabau D, Georgescu , Grobbelaar AO, Constantinescu MA

Background Perforator flaps have led to a revolution in reconstructive surgery by reducing donor site morbidity. However, many surgeons have witnessed partial flap necrosis. Experimental methods to increase inflow have...
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Worsened survival in the head-up tilt position cardiopulmonary resuscitation in a porcine cardiac arrest model

Park YJ, Hong KJ, Shin SD, Kim TY, Ro YS, Song KJ, Ryu HH

OBJECTIVE: Head elevation at an angle of 30° during cardiopulmonary resuscitation (CPR) was hemodynamically beneficial compared to supine position in a previous porcine cardiac arrest experimental study. However, survival benefit...
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Specification of Subject Sex in Oncology-Related Animal Studies

Lee S, Kim WJ, Jeon Y, Lim CH, Sun K

BACKGROUND: Growing evidence for clinically significant differences between the sexes has attracted the attention of researchers. However, failures to report a test animal sex and balance the sex ratios of...
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Does pediatric anesthesia cause brain damage? – Addressing parental and provider concerns in light of compelling animal studies and seemingly ambivalent human data

Lee JR, Loepke AW

Anesthesia facilitates surgery in millions of young children every year. Structural brain abnormalities and functional impairment observed in animals have created substantial concerns among clinicians, parents, and government regulators. Clinical...
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The Efficacy and Underlying Mechanism of Moxibustion in Preventing Cognitive Impairment: A Systematic Review of Animal Studies

Choe S, Cai M, Jerng UM, Lee JH

Cognitive impairment is age-related and manageable only with early diagnosis and prevention. Moxibustion is widely accepted in East Asia as useful for preventing cognitive impairment. This systematic review of animal...
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Animal Experimentation for Bariatric Surgery

Ha TK

Bariatric surgery is considered the most effective treatment for reducing and maintaining weight for morbid obesity. Moreover, this surgery not only reduces weight but also improves comorbidity. However, concern about...
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Safety and Efficacy of an Aortic Arch Stent Graft with Window-Shaped Fenestration for Supra-Aortic Arch Vessels: an Experimental Study in Swine

Park JH, Lee HC, Choe JC, Kim SP, Park TS, Ahn J, Park JS, Lee HW, Oh JH, Choi JH, Cha KS

BACKGROUND AND OBJECTIVES: Thoracic endovascular aortic repair exhibits limitations in cases where the aortic pathology involves the aortic arch. We had already developed a fenestrated aortic stent graft (FASG) with...
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Development of a Swine Benign Biliary Stricture Model Using Endoscopic Biliary Radiofrequency Ablation

Park JS, Jeong S, Kim JM, Park SS, Lee DH

The large animal model with benign biliary stricture (BBS) is essential to undergo experiment on developing new devices and endoscopic treatment. This study conducted to establish a clinically relevant porcine...
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Use of Animals for Nursing Research in Korea

Yoo HY

PURPOSE: The purpose of this study was to analyze the trends in Korea of nursing research using animals. METHODS: 45 articles were reviewed with descriptive statistics from 2000 to 2015. RESULTS: Nearly...
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Dynamic Contrast-Enhanced MRI Using a Macromolecular MR Contrast Agent (P792): Evaluation of Antivascular Drug Effect in a Rabbit VX2 Liver Tumor Model

Park HS, Han JK, Lee JM, Kim YI, Woo S, Yoon JH, Choi JY, Choi BI

OBJECTIVE: To evaluate the utility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using macromolecular contrast agent (P792) for assessment of vascular disrupting drug effect in rabbit VX2 liver tumor models. MATERIALS...
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In vivo comparison between the effects of chemically modified hydrophilic and anodically oxidized titanium surfaces on initial bone healing

Lee HJ, Yang IH, Kim SK, Yeo IS, Kwon TK

PURPOSE: The aim of this study was to investigate the combined effects of physical and chemical surface factors on in vivo bone responses by comparing chemically modified hydrophilic sandblasted, large-grit,...
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Safety and Efficacy of a Novel, Fenestrated Aortic Arch Stent Graft with a Preloaded Catheter for Supraaortic Arch Vessels: An Experimental Study in Swine

Kim SP, Lee HC, Park TS, Ahn JH, Lee HW, Park JH, Oh J, Choi JH, Cha KS

Thoracic endovascular aortic repair (TEVAR) shows limitations in cases in which the aortic pathology involves the aortic arch. The study aims were to test a fenestrated aortic arch stent graft...
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Paracrine effect of the bone morphogeneticprotein-2 at the experimental site on healing of the adjacent control site: a study in the rabbit calvarial defect model

Lee JW, Lim HC, Lee EU, Park JY, Lee JS, Lee DW, Jung UW, Choi SH

PURPOSE: The aim of this study was to assess the possible paracrine effect of bone morphogeneticprotein-2 (BMP-2) at the experimental site on the adjacent control site for validating a rabbit...
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Use of Animal Laboratory for a Surgeon

Choi D

Research is one of the available methods by which scientists can obtain results from various and complex events. Especially, experimental research is a fundamental method from which we are able...
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Role of Experimental Research as a Hepatobiliary Surgeon

Park IY

In the 1970s, surgeons performed a variety of experimental procedures on animals. Experimental surgery has scientific merit and allows surgeons to carry out many studies to understand pathophysiology in several...
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Experiment of Ischemia/Reperfusion Injury of the Cirrhotic Liver in the Murine Mouse Model

Kang KJ

As a medical doctor, the final goal of any type of research is focused on better treatment or contemporary care of the patient. As a surgeon, the research is focused...
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