- Multiple Recurrent Cerebral Hemorrhages Related to Cerebral Amyloid Angiopathy with Arterial Hypertension
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Jung JH, Shin DA, Gong TS, Kwon CY
- KMID: 2018762
- J Korean Neurosurg Soc.
- 2006 Jun;39(6):447-450.
Cerebral amyloid angiopathy(CAA) is characterized by the deposition of amyloid beta-protein in the walls of small to medium-sized arteries of the leptomeninges and cerebral cortex. While often asymptomatic, CAA can... -
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- A Newer Therapeutic Strategies For Alzheimer's Disease
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Han SH
- KMID: 2185998
- J Korean Neurol Assoc.
- 2001 Nov;19(6):559-565.
Alzheimer's disease (AD) is characterized pathologically by cholinergic deficits, extracelluar amyloid deposit, intra-neuronal neurofibrillary tangles, gliosis and neuronal and synaptic loss. The primary therapeutic approach has been cholinergic augumentation by... -
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- Mercury induced the Accumulation of Amyloid Beta (Abeta) in PC12 Cells: The Role of Production and Degradation of Abeta
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Song JW, Choi BS
- KMID: 2317841
- Toxicol Res.
- 2013 Dec;29(4):235-240.
Extracellular accumulation of amyloid beta protein (Abeta) plays a central role in Alzheimer's disease (AD). Some metals, such as copper, lead, and aluminum can affect the Abeta accumulation in the... -
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- Protective Effect of Fibroin BF-7 on Neuronal Cell Death in Alzheimer Model using Amyloid beta Peptide
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Lee DY, Yun JY, Kim JI, Kim DH, Han IS, Lee WB
- KMID: 2092890
- Korean J Anat.
- 2007 Mar;40(1):57-67.
Factors such as senescence,stress and neurodegenerative diseases,including Alzheimer's disease, contribute to the impairment of organs,especially the brain.They also negatively affect normal brain functions such as memory and cognition.In this study,the... -
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- The Effects of Psychotropic Drugs on the beta-Amyloid-Induced Cytotoxicity in PC12 Cells
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Kim TS, Lee C, Lee SJ, Toh KY, Kim JJ, Paik IH
- KMID: 2340493
- J Korean Neuropsychiatr Assoc.
- 2000 Sep;39(5):936-943.
OBJECTIVE: Amyloid beta protein(Abeta) has been regarded to be toxic to neurons in vitro. However, the mechanism of action leading to neuronal death remains unknown. In this study, we report... -
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- Characterizing affinity epitopes between prion protein and beta-amyloid using an epitope mapping immunoassay
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Kang M, Kim SY, An SS, Ju YR
- KMID: 2154253
- Exp Mol Med.
- 2013 Aug;45(8):e34.
Cellular prion protein, a membrane protein, is expressed in all mammals. Prion protein is also found in human blood as an anchorless protein, and this protein form is one of... -
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- The Effects of (-)-Epigallocatechin Gallate on Rat Hippocampal Organotypic Slice Cultures Treated with the 1-42 beta-amyloid Protein
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Youn YC
- KMID: 1852262
- J Korean Neurol Assoc.
- 2005 Dec;23(6):806-813.
BACKGROUND: Considerable evidences suggest that the beta-amyloid acts as a neurotoxin, and the epigallocatechin-3- gallate (EGCG) has the anti-inflammatory and anti-oxidant properties. The purpose of this study was to investigate... -
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- The Clinical Usefulness of Beta-Amyloid Positron Emission Tomography Imaging in the Elderly Patients: Case Series & Brief Review
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Oh JH, Na SJ, Lee SY, Lee HK, Lee KU, Kweon YS, Ahn RY, Lee SY, Lee CT
- KMID: 2186124
- J Korean Geriatr Psychiatry.
- 2016 Apr;20(1):38-44.
- doi: 10.0000/jkgp.2016.20.1.38
The aim was to evaluate the diagnostic utility of beta-amyloid positron emission tomography (PET) in elderly patients with cognitive impairment in the clinical setting. Five subjects underwent beta-amyloid PET imaging... -
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- Amyloid-beta oligomers regulate the properties of human neural stem cells through GSK-3beta signaling
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Lee IS, Jung K, Kim IS, Park KI
- KMID: 2154279
- Exp Mol Med.
- 2013 Nov;45(11):e60.
Alzheimer's disease (AD) is the most common cause of age-related dementia. The neuropathological hallmarks of AD include extracellular deposition of amyloid-beta peptides and neurofibrillary tangles that lead to intracellular hyperphosphorylated... -
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- Primary Age-Related Tauopathy: An Elderly Brain Pathology Frequently Encountered during Autopsy
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Kim D, Kim HS, Choi SM, Kim BC, Lee MC, Lee KH, Lee JH
- KMID: 2449338
- J Pathol Transl Med.
- 2019 May;53(3):159-163.
- doi: 10.4132/jptm.2019.03.14
Due to the progressive aging of Korean society and the introduction of brain banks to the Korean medical system, the possibility that pathologists will have access to healthy elderly brains... -
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- Diverse Molecular Targets for Therapeutic Strategies in Alzheimer's Disease
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Han SH, Mook-Jung
- KMID: 1789947
- J Korean Med Sci.
- 2014 Jul;29(7):893-902.
- doi: 10.3346/jkms.2014.29.7.893
Alzheimer's disease (AD) is the most common form of dementia caused by neurodegenerative process and is tightly related to amyloid beta (Abeta) and neurofibrillary tangles. The lack of early diagnostic... -
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- Reactive Oxygen Species Production, Expression of Complement Regulator Genes and Phagocytosis in the Murine Microglial Cell after Administration of Beta-Amyloid(A beta1-42) Protein
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Choi YS, Lee KS, Kim SH
- KMID: 1626985
- J Korean Neurol Assoc.
- 2005 Feb;23(1):88-95.
BACKGROUND: Microglia is a primary cellular component of neuritic plaques in Alzheimer's disease. Beta amyloid deposits attract microglia and activate them to produce inflammatory mediators. The objectives of this study... -
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- Alzheimer's Disease and Apoptosis
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Kim YH, Kim YK, Kim SH, Lee SK, Kim SS, Kim HS, Park CH, Jeong SJ, Suh YH
- KMID: 1834623
- J Korean Soc Biol Psychiatry.
- 1998 Jun;5(1):66-70.
Apoptosis is a form of cell death in which the cells shrink and exhibit nuclear chromatin condensation and DNA fragmentation, and yet maintain membrane integrity. Many lines of evidence have... -
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- Role of Sleep Disturbance in the Trajectory of Alzheimer's Disease
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Kang DW, Lee CU, Lim HK
- KMID: 2378477
- Clin Psychopharmacol Neurosci.
- 2017 May;15(2):89-99.
- doi: 10.9758/cpn.2017.15.2.89
Sleep disturbances such as insomnia, hypersomnia, and circadian rhythm disturbance are common in normal elderly and Alzheimer's disease (AD) patients. To date, special attention has been paid to sleep disturbance... -
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- Biological Predictors of Alzheimer's Disease Treatment
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Joo SH, Im J, Lee CU
- KMID: 2299836
- Korean J Biol Psychiatry.
- 2014 Nov;21(4):115-117.
- doi: 10.0000/kjbp.2014.21.4.115
Variety of biomarkers that are related to the Alzheimer's disease and its diagnosis and progress have been found. However, research lacks in predicting the reaction of the treatment. In addition,... -
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- PC12 Cell Apoptosis Mediated by Reactive Oxygen Species with Various Agents is Reduced Effectively by Flavonoid Antioxidants
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Joe S, Bae JA, Lee KY
- KMID: 1883448
- Chonnam Med J.
- 2004 Dec;40(4):173-179.
Reactive oxygen species (ROS) has many biological roles. Apoptosis is also induced by ROS. In this study, we show the involvement of ROS on the PC12 cell apoptosis induced by... -
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- Cerebral Amyloid Angiopathy: Emerging Concepts
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Yamada M
- KMID: 2223683
- J Stroke.
- 2015 Jan;17(1):17-30.
- doi: 10.5853/jos.2015.17.1.17
Cerebral amyloid angiopathy (CAA) involves cerebrovascular amyloid deposition and is classified into several types according to the amyloid protein involved. Of these, sporadic amyloid beta-protein (Abeta)-type CAA is most commonly... -
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- Neurobiology of Alzheimer's Disease
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Chung YC, Seo SW, Lee SH
- KMID: 2142160
- J Korean Soc Biol Psychiatry.
- 2001 Jun;8(1):62-70.
Alzheimer's disease(AD) is associated with a characteristic neuropathology. The major hallmarks of AD are senile plaques(SPs) and neurofibrillary tangles(NFTs). beta-amyloid protein(Abeta) is derived from the proteolysis of amyloid precursor protein(APP)... -
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- Effects of NADPH Oxidase Inhibitors and Mitochondria-Targeted Antioxidants on Amyloid βâ‚â‚‹â‚„â‚‚-Induced Neuronal Deaths in Mouse Mixed Cortical Cultures
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Hwang S, Kim JK
- KMID: 2420883
- Chonnam Med J.
- 2018 Sep;54(3):159-166.
- doi: 10.4068/cmj.2018.54.3.159
The Amyloid β peptide (Aβ) is a main component of senile plaques in Alzheimer's disease. Currently, NADPH oxidase (NOX) and mitochondria are considered as primary sources of ROS induced by... -
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- The association between PGC-1a and Alzheimer's disease
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Sweeney G, Song J
- KMID: 2308926
- Anat Cell Biol.
- 2016 Mar;49(1):1-6.
- doi: 10.5115/acb.2016.49.1.1
Alzheimer's disease (AD) is a neurodegenerative disorder and its reported pathophysiological features in the brain include the deposition of amyloid beta peptide, chronic inflammation, and cognitive impairment. The incidence of... -
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