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A Case of Sulfasalazine-Induced Hypersensitivity Syndrome Confirmed by Enzyme-Linked Immunospot Assay

Phatharacharukul P, Klaewsongkram J

A 24-year-old male with a history of spondyloarthropathy presented with high fever, cervical lymphadenopathy and generalized maculopapular rash. He was treated with prednisolone for chronic uveitis before being switched to...
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The Influence of IgE on Cultured Human Mast Cells

Frandsen P, Krohn IJ, Hoffmann H, Schiotz PO

PURPOSE: The mast cell plays a pivotal role in the human immune response. Crosslinking of 2 IgE molecules bound to the high affinity IgE receptor (FcepsilonRI) on the surface of...
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Effect of Cholesterol Depletion on Interleukin-8 Production in Human Respiratory Epithelial Cells

Kim MJ, Hong JY, Lee KE, Kim KW, Sohn MH, Kim KE

PURPOSE: The lipid entities of cell membranes are components of the immune system and important mediators of inflammation. Despite increasing interest in the function of epithelial cells in inflammation, the...
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The Effects of Storage Conditions on the Stability of House Dust Mite Extracts

Jeong KY, Choi SY, Han IS, Lee JH, Lee JS, Hong CS, Park JW

PURPOSE: Allergen extracts from the house dust mite (HDM, Dermatophagoides pteronyssinus) are widely utilized for diagnosis and treatment of allergic diseases. It is known that allergen extracts degrade and lose...
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MRI Reveals Edema in Larynx (But Not in Brain) During Anaphylactic Hypotension in Anesthetized Rats

Toyota I, Tanida M, Shibamoto , Wang M, Kurata Y, Tonami H

PURPOSE: Anaphylactic shock is sometimes accompanied by local interstitial edema due to increased vascular permeability. We performed magnetic resonance imaging (MRI) to compare edema in the larynx and brain of...
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Threshold for Positivity and Optimal Dipyrone Concentration in Flow Cytometry-Assisted Basophil Activation Test

Hagau N, Longrois D, Petrisor C

PURPOSE: Basophil activation occurs both in patients with immediate hypersensitivity reactions to anti-inflammatory drugs and in healthy controls in a dose-dependent manner. Our aims were to define the optimal basophil...
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IL-13 R110Q, a Naturally Occurring IL-13 Polymorphism, Confers Enhanced Functional Activity in Cultured Human Bronchial Smooth Muscle Cells

He YF, Hua L, Bao YX, Liu QH, Chu Y, Fang DZ

PURPOSE: Interleukin (IL)-13, a Th2-type cytokine, plays a pivotal role in the pathogenesis of asthma through its direct effects on airway smooth muscles. A naturally occurring IL-13 polymorphism, R110Q, is...
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IL-4 Receptor alpha Polymorphisms May Be a Susceptible Factor for Work-Related Respiratory Symptoms in Bakery Workers

Hur GY, Ye YM, Koh DH, Kim SH, Park HS

PURPOSE: The IL-4 and IL-4 receptor alpha (IL-4Ralpha) genes are the key candidate genes for atopy and asthma susceptibility. Exposure to wheat flour can cause IgE sensitization and respiratory symptoms...
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Respiratory Effects of the Hebei Spirit Oil Spill on Children in Taean, Korea

Jung SC, Kim KM, Lee KS, Roh S, Jeong WC, Kwak SJ, Lee IJ, Choi YH, Noh SR, Hur JI, Jee YK

PURPOSE: The oil spill from the Heibei Spirit in December 2007 contaminated the Yellow Coast of South Korea. We evaluated the respiratory effects of that spill on children who lived...
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Lost to Follow-Up in Asthmatics Does Not Mean Treatment Failure: Causes and Clinical Outcomes of Non-Adherence To Outpatient Treatment In Adult Asthma

Kang MG, Kim JY, Jung JW, Song WJ, Cho SH, Min KU, Kang HR

PURPOSE: Long-term asthma management is recommended to asthmatics; however, many patients do not adhere to follow-up treatment. It is unclear why many asthmatics do not adhere to follow-up treatment and...
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Diagnosis and Management of Grain-Induced Asthma

Quirce S, Diaz-Perales A

Grain-induced asthma is a frequent occupational allergic disease mainly caused by inhalation of cereal flour or powder. The main professions affected are bakers, confectioners, pastry factory workers, millers, farmers, and...
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Mechanisms of Asthma and Implications for Its Prevention and Treatment: A Personal Journey

Holgate ST

My research career has focused on the causes of asthma and its treatment. After establishing the key role that mast cells play in the inflammatory response in asthma, attention was...
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Intermittent to Mild Asthma: The Need for Continued Treatment

Yoon HJ

No abstract available.
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