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An Alternative Dendritic Cell-Induced Murine Model of Asthma Exhibiting a Robust Th2/Th17-Skewed Response

Park SC, Kim H, Bak Y, Shim D, Kwon KW, Kim CH, Yoon JH, Shin SJ

  • Allergy Asthma Immunol Res.
  • 2020 May;12(3):537-555.
  • doi: 10.4168/aair.2020.12.3.537
PURPOSE: Simple and reliable animal models of human diseases contribute to the understanding of disease pathogenesis as well as the development of therapeutic interventions. Although several murine models to mimic...
Oxidative Stress Modulates the Expression Pattern of Peroxiredoxin-6 in Peripheral Blood Mononuclear Cells of Asthmatic Patients and Bronchial Epithelial Cells

Shim HJ, Park SY, Kwon HS, Song WJ, Kim TB, Moon KA, Choi JP, Kim SJ, Cho YS

  • Allergy Asthma Immunol Res.
  • 2020 May;12(3):523-536.
  • doi: 10.4168/aair.2020.12.3.523
PURPOSE: Reduction-oxidation reaction homeostasis is vital for regulating inflammatory conditions and its dysregulation may affect the pathogenesis of chronic airway inflammatory diseases such as asthma. Peroxiredoxin-6, an important intracellular anti-oxidant...
Role of IL-17A in Chronic Rhinosinusitis With Nasal Polyp

Ryu G, Bae JS, Kim JH, Kim EH, Lyu L, Chung YJ, Mo JH

  • Allergy Asthma Immunol Res.
  • 2020 May;12(3):507-522.
  • doi: 10.4168/aair.2020.12.3.507
PURPOSE: Th17-associated inflammation is increased in chronic rhinosinusitis with nasal polyp (CRSwNP), and is associated with disease severity and steroid resistance. Overexpressed interleukin (IL)-17A affects CRSwNP by tissue remodeling, eosinophilic...
A Prospective Observation of Psychological Distress in Patients With Anaphylaxis

Lee Y, Chang HY, Kim SH, Yang MS, Koh YI, Kang HR, Choi JH, Kim CW, Park HK, Kim JH, Nam YH, Kim TB, Hur GY, Jung JW, Park KH, Kim MA, Kim J, Yoon J, Ye YM

  • Allergy Asthma Immunol Res.
  • 2020 May;12(3):496-506.
  • doi: 10.4168/aair.2020.12.3.496
PURPOSE: Anaphylaxis is an immediate allergic reaction characterized by potentially life-threatening, severe, systemic manifestations. While studies have evaluated links between serious illness and posttraumatic stress disorder (PTSD), few have investigated...
Hospitalization Due to Asthma Exacerbation: A China Asthma Research Network (CARN) Retrospective Study in 29 Provinces Across Mainland China

Lin J, Xing B, Tang H, Yang L, Yuan Y, Gu Y, Chen P, Liu X, Zhang J, Liu H, Wang C, Zhou W, Sun D, Chen Y, Chen Z, Huang M, Lin Q, Hu C, Yang X, Huo J, Ye X, Zhou X, Jiang P, Zhang W, Huang Y, Dai L, Liu R, Cai S, Xu J, Zhou J, on behalf of China Asthma Research Network

  • Allergy Asthma Immunol Res.
  • 2020 May;12(3):485-495.
  • doi: 10.4168/aair.2020.12.3.485
PURPOSE: Details of patients hospitalized for asthma exacerbation in mainland China are lacking. To improve disease control and reduce economic burden, a large sample survey among this patient population is...
Increasing Prevalence and Mortality of Asthma With Age in Korea, 2002–2015: A Nationwide, Population-Based Study

Lee E, Kim A, Ye YM, Choi SE, Park HS

  • Allergy Asthma Immunol Res.
  • 2020 May;12(3):467-484.
  • doi: 10.4168/aair.2020.12.3.467
PURPOSE: The prevalence of asthma is increasing globally as the world population increases; however, and the prevalence and mortality of asthma have not been extensively investigated. Also, the effects of...
Efficacy and Safety of a Pressurized Metered-Dose Inhaler in Older Asthmatics: Comparison to a Dry Powder Inhaler in a 12-Week Randomized Trial

Woo SD, Ye YM, Lee Y, Lee SH, Shin YS, Park JH, Choi H, Lee HY, Shin HJ, Park HS

  • Allergy Asthma Immunol Res.
  • 2020 May;12(3):454-466.
  • doi: 10.4168/aair.2020.12.3.454
PURPOSE: Asthma control in older asthmatics is often less effective, which may be attributed to small airway dysfunction and poor inhalation technique. We compared the efficacy of 2 inhalers (fluticasone...
Risk Factors for Acute Exacerbations in Elderly Asthma: What Makes Asthma in Older Adults Distinctive?

Sohn KH, Song WJ, Park JS, Park HW, Kim TB, Park CS, Cho SH, on behalf of the Elderly Asthma Cohort in Korea Group

  • Allergy Asthma Immunol Res.
  • 2020 May;12(3):443-453.
  • doi: 10.4168/aair.2020.12.3.443
PURPOSE: Asthma in the elderly (EA; ≥ 65 years of age) is increasing, adding a heavy socioeconomic burden to the healthcare system. However, little is known about risk factors associated...
Evaluation of Drug-Induced Liver Injury Developed During Hospitalization Using Electronic Health Record (EHR)-Based Algorithm

Kang Y, Kim SH, Park SY, Park BY, Lee JH, An J, Won HK, Song WJ, Kwon HS, Cho YS, Moon HB, Shim JH, Yang MS, Kim TB

  • Allergy Asthma Immunol Res.
  • 2020 May;12(3):430-442.
  • doi: 10.4168/aair.2020.12.3.430
PURPOSE: The incidence of drug-induced liver injury (DILI) has been increasing; however, few algorithms are available to identify DILI in electronic health records (EHRs). We aimed to identify and evaluate...
Relationship of Microbial Profile With Airway Immune Response in Eosinophilic or Neutrophilic Inflammation of Asthmatics

Son JH, Kim JH, Chang HS, Park JS, Park CS

  • Allergy Asthma Immunol Res.
  • 2020 May;12(3):412-429.
  • doi: 10.4168/aair.2020.12.3.412
PURPOSE: Different characteristics of airway microbiome in asthmatics may lead to differential immune responses, which in turn cause eosinophilic or neutrophilic airway inflammation. However, the relationships among these factors have...
Understanding the Molecular Mechanisms of Asthma through Transcriptomics

Park HW, Weiss ST

  • Allergy Asthma Immunol Res.
  • 2020 May;12(3):399-411.
  • doi: 10.4168/aair.2020.12.3.399
The transcriptome represents the complete set of RNA transcripts that are produced by the genome under a specific circumstance or in a specific cell. High-throughput methods, including microarray and bulk...
Innate Lymphoid Cells in the Airways: Their Functions and Regulators

Orimo K, Saito H, Matsumoto , Morita H

  • Allergy Asthma Immunol Res.
  • 2020 May;12(3):381-398.
  • doi: 10.4168/aair.2020.12.3.381
Since the airways are constantly exposed to various pathogens and foreign antigens, various kinds of cells in the airways—including structural cells and immune cells—interact to form a precise defense system...
Active Pharmacovigilance of Drug-Induced Liver Injury Using Electronic Health Records

Kim SH

  • Allergy Asthma Immunol Res.
  • 2020 May;12(3):378-380.
  • doi: 10.4168/aair.2020.12.3.378
No abstract available.
Does the Difference in Microbial Patterns in the Airways Induce Distinct Endotypes of Asthma?

Cho YJ

  • Allergy Asthma Immunol Res.
  • 2020 May;12(3):375-377.
  • doi: 10.4168/aair.2020.12.3.375
No abstract available.

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