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Microarray-Based Multivariate Analysis of the Effectiveness of Sublingual Immunotherapy for Cedar Pollinosis

Gotoh M, Kaminuma O, Hiroi T, Okubo K

  • Allergy Asthma Immunol Res.
  • 2018 Sep;10(5):562-569.
  • doi: 10.4168/aair.2018.10.5.562
Sublingual immunotherapy (SLIT) is an effective treatment for allergic diseases. However, the mechanism by which this therapy exhibits its efficacy has not been fully delineated. To elucidate the mechanisms of...
The Fas Signaling Pathway Is a Common Genetic Risk Factor for Severe Cutaneous Drug Adverse Reactions Across Diverse Drugs

Park HW, Kim SH, Chang YS, Kim SH, Jee YK, Lee AY, Jang IJ, Park HS, Min KU

  • Allergy Asthma Immunol Res.
  • 2018 Sep;10(5):555-561.
  • doi: 10.4168/aair.2018.10.5.555
PURPOSE: Human leukocyte antigen (HLA) has been recognized as the most important genetic risk factor for severe cutaneous adverse drug reactions (SCARs) caused by certain drugs. However, cumulated observations suggest...
Bcl11b Regulates IL-17 Through the TGF-β/Smad Pathway in HDM-Induced Asthma

Chen S, Han Y, Chen H, Wu J, Zhang M

  • Allergy Asthma Immunol Res.
  • 2018 Sep;10(5):543-554.
  • doi: 10.4168/aair.2018.10.5.543
PURPOSE: T helper (Th) 17 cells play a critical role in the development of asthma, but the underlying mechanism of how interleukin (IL)-17 is regulated in allergic airway inflammation is...
Impact of the Endothelial Tight Junction Protein Claudin-5 on Clinical Profiles of Patients With COPD

Kim BG, Lee PH, Lee SH, Baek AR, Park JS, Lee J, Park SW, Kim DJ, Park CS, Jang AS

  • Allergy Asthma Immunol Res.
  • 2018 Sep;10(5):533-542.
  • doi: 10.4168/aair.2018.10.5.533
PURPOSE: The tight junction protein claudin-5 (CLDN5) is critical to the control of endothelial cellular polarity and pericellular permeability. The role of CLDN5 in chronic obstructive pulmonary disease (COPD) remains...
Lactobacillus plantarum-derived Extracellular Vesicles Protect Atopic Dermatitis Induced by Staphylococcus aureus-derived Extracellular Vesicles

Kim MH, Choi SJ, Choi HI, Choi JP, Park HK, Kim EK, Kim MJ, Moon BS, Min TK, Rho M, Cho YJ, Yang S, Kim YK, Kim YY, Pyun BY

  • Allergy Asthma Immunol Res.
  • 2018 Sep;10(5):516-532.
  • doi: 10.4168/aair.2018.10.5.516
PURPOSE: The microbial environment is an important factor that contributes to the pathogenesis of atopic dermatitis (AD). Recently, it was revealed that not only bacteria itself but also extracellular vesicles...
Association Between Airway Parameters and Abdominal Fat Measured via Computed Tomography in Asthmatic Patients

Yang MS, Choi S, Choi Y, Jin KN

  • Allergy Asthma Immunol Res.
  • 2018 Sep;10(5):503-515.
  • doi: 10.4168/aair.2018.10.5.503
PURPOSE: We aimed to investigate whether airway parameters, assessed via computed tomography (CT), are associated with abdominal fat areas and to compare the clinical characteristics of asthmatic patients with and...
Two-Track Medical Treatment Strategy According to the Clinical Scoring System for Chronic Rhinosinusitis

Kim DK, Kang SI, Kong IG, Cho YH, Song SK, Hyun SJ, Cho SD, Han SY, Cho SH, Kim DW

  • Allergy Asthma Immunol Res.
  • 2018 Sep;10(5):490-502.
  • doi: 10.4168/aair.2018.10.5.490
PURPOSE: The previously reported Japanese clinical scoring study (JESREC) suggests that chronic rhinosinusitis (CRS) can be divided into 4 subtypes according to the degree of eosinophilic CRS (ECRS) and offers...
Measurement of Exhaled Nitric Oxide in Children: A Comparison Between NObreath® and NIOX VERO® Analyzers

Inoue Y, Sato S, Manabe T, Makita E, Chiyotanda M, Takahashi , Yamamoto H, Yanagida N, Ebisawa M

  • Allergy Asthma Immunol Res.
  • 2018 Sep;10(5):478-489.
  • doi: 10.4168/aair.2018.10.5.478
PURPOSE: Few studies have compared fractional exhaled nitric oxide (FeNO) measurement by NIOX VERO® (NOV) and other devices in children. Moreover, there is no agreement between differences in FeNO values...
Prevalence, Risk Factors and Cutoff Values for Bronchial Hyperresponsiveness to Provocholine in 7-Year-Old Children

Jung S, Suh DI, Lee SY, Yoon J, Cho HJ, Kim YH, Yang SI, Kwon JW, Jang GC, Sun YH, Woo SI, Youn YS, Park KS, Cho HJ, Kook MH, Yi HR, Chung HL, Kim JH, Kim HY, Jung JA, Woo HO, Hong SJ

  • Allergy Asthma Immunol Res.
  • 2018 Sep;10(5):466-477.
  • doi: 10.4168/aair.2018.10.5.466
BACKGROUND: A US Food and Drug Administration (FDA)-approved drug methacholine chloride (Provocholine®) was recently introduced to Korea where it is now widely used in clinical practice. We aimed to evaluate...
Effects of Antibiotics on the Development of Asthma and Other Allergic Diseases in Children and Adolescents

Kim DH, Han K, Kim SW

  • Allergy Asthma Immunol Res.
  • 2018 Sep;10(5):457-465.
  • doi: 10.4168/aair.2018.10.5.457
PURPOSE: Our aim was to explore whether antibiotic exposure in children and adolescents is associated with the later development of allergic diseases, using nationwide population-based claims data. METHODS: We collected information...
Role of Natural Killer Cells in Airway Inflammation

Kim JH, Jang YJ

  • Allergy Asthma Immunol Res.
  • 2018 Sep;10(5):448-456.
  • doi: 10.4168/aair.2018.10.5.448
Natural killer (NK) cells have an immune regulatory function as well as cytotoxicity against tumor or infected cells. In the airway, although NK cells constitute a small proportion of the...
Autoimmune Responses in Severe Asthma

Mukherjee , Nair P

  • Allergy Asthma Immunol Res.
  • 2018 Sep;10(5):428-447.
  • doi: 10.4168/aair.2018.10.5.428
Asthma and autoimmune diseases both result from a dysregulated immune system, and have been conventionally considered to have mutually exclusive pathogenesis. Autoimmunity is believed to be an exaggerated Th1 response,...
Can the Use of Antibiotics Alter the Susceptibility to Allergic Diseases?

Lee SY

  • Allergy Asthma Immunol Res.
  • 2018 Sep;10(5):425-427.
  • doi: 10.4168/aair.2018.10.5.425
No abstract available.

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