- Efficacy and Safety of Ceritinib 450 mg/day with Food and 750 mg/day in Fasted State in Treatment-Naïve Patients with ALK+ Non–Small Cell Lung Cancer: Results from the ASCEND-8 Asian Subgroup Analysis
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Cho BC, Kim DW, Batra U, Park K, Kim SW, Yang CT, Voon PJ, Sriuranpong V, Babu KG, Amin K, Wang Y, Sen P, Slimane K, Geater S
- KMID: 2537994
- Cancer Res Treat.
- 2023 Jan;55(1):83-93.
- doi: 10.4143/crt.2021.1571
Purpose Previous report from the ASCEND-8 trial showed consistent efficacy with less gastrointestinal (GI) toxicity in patients with anaplastic lymphoma kinase-rearranged (ALK+) advanced/metastatic non–small cell lung cancer (NSCLC) treated with... -
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- Prognostic role of ALK-1 and h-TERT expression in glioblastoma multiforme: correlation with ALK gene alterations
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Elsers D, Temerik DF, Attia AM, Hadia A, Hussien MT
- KMID: 2515926
- J Pathol Transl Med.
- 2021 May;55(3):212-224.
- doi: 10.4132/jptm.2021.03.15
Background: Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that is expressed in the developing central and peripheral nervous systems during embryogenesis. Human telomerase reverse transcriptase (h-TERT) protein resumption... -
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- Characteristics of Renal Cell Carcinoma Harboring TPM3-ALK Fusion
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Woo CG, Yun SJ, Son SM, Lim YH, Lee OJ
- KMID: 2470924
- Yonsei Med J.
- 2020 Mar;61(3):262-266.
- doi: 10.3349/ymj.2020.61.3.262
The World Health Organization 2016 edition assigned anaplastic lymphoma kinase (ALK) rearrangement-associated renal cell carcinoma (ALK-RCC) as an emerging renal tumor entity. Identifying ALK-RCC is important because ALK inhibitors have... -
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- Anaplastic lymphoma kinase (ALK)-expressing Lung Adenocarcinoma with Combined Neuroendocrine Component or Neuroendocrine Transformation: Implications for Neuroendocrine Transformation and Response to ALK-tyrosine Kinase Inhibitors
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Sim J, Kim H, Hyeon J, Choi YL, Han J
- KMID: 2408058
- J Korean Med Sci.
- 2018 Apr;33(15):e123.
- doi: 10.3346/jkms.2018.33.e123
BACKGROUND: Anaplastic lymphoma kinase tyrosine kinase inhibitors (ALK-TKIs) are usually effective in lung adenocarcinoma patients with anaplastic lymphoma kinase (ALK) rearrangement. However, even after a good response to ALK-TKI therapy,... -
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- Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center
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Telugu RB, Prabhu AJ, Kalappurayil NB, Mathai J, Gnanamuthu BR, Manipadam
- KMID: 2392593
- J Pathol Transl Med.
- 2017 May;51(3):255-263.
- doi: 10.4132/jptm.2017.01.12
BACKGROUND: Inflammatory myofibroblastic tumor is a histopathologically distinctive neoplasm of children and young adults. According to World Health Organization (WHO) classification, inflammatory myofibroblastic tumor is an intermediate-grade tumor, with potential... -
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- Evolving Cancer Classification in the Era of Personalized Medicine: A Primer for Radiologists
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O'Neill AC, Jagannathan JP, Ramaiya NH
- KMID: 2468118
- Korean J Radiol.
- 2017 Feb;18(1):6-17.
- doi: 10.3348/kjr.2017.18.1.6
Traditionally tumors were classified based on anatomic location but now specific genetic mutations in cancers are leading to treatment of tumors with molecular targeted therapies. This has led to a... -
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- The Influence of Biomarker Mutations and Systemic Treatment on Cerebral Metastases from NSCLC Treated with Radiosurgery
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Lee MH, Kong DS, Seol HJ, Nam DH, Lee JI
- KMID: 2365583
- J Korean Neurosurg Soc.
- 2017 Jan;60(1):21-29.
- doi: 10.3340/jkns.2016.0404.005
OBJECTIVE: The purpose of this study was to analyze outcomes and identify prognostic factors in patients with cerebral metastases from non-small cell lung cancer (NSCLC) treated with gamma knife radiosurgery... -
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- Coexistence of an EGFR Mutation and an ALK Rearrangement in a Patient with Lung Adenocarcinoma: a Case Report
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Kim MA, Kang JH, Kim IH, Kim TJ, Kim SJ, Sung SW, Huo SM
- KMID: 2268896
- Korean J Med.
- 2016 Jan;90(1):72-77.
- doi: 10.3904/kjm.2016.90.1.72
A 58 year-old woman was diagnosed with lung adenocarcinoma (cT3N1M0). We detected a point mutation in epidermal growth factor receptor (EGFR) exon 21 (L858R) and an echinoderm microtubule-associated protein-like 4-... -
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- Successful Treatment of Crizotinib-Associated Severe Hepatotoxicity in Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer
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Jin J, Ahn SY, Kim S, Lee HS, Oh IJ, Kim KS, Kim YC, Choi YD
- KMID: 1910333
- Soonchunhyang Med Sci.
- 2014 Jun;20(1):35-38.
Crizotinib-associated severe hepatotoxicity has been rarely reported and experts recommended stopping crizotinib treatment in patients with grade 3/4 transaminase elevation. We experienced a case of anaplastic lymphoma kinase-positive non-small cell... -
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- ALK-Positive Renal Cell Carcinoma in a Large Series of Consecutively Resected Korean Renal Cell Carcinoma Patients
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Lee C, Park JW, Suh JH, Nam KH, Moon KC
- KMID: 2141006
- Korean J Pathol.
- 2013 Oct;47(5):452-457.
BACKGROUND: Recently, there have been a few reports of renal cell carcinoma (RCC) cases with anaplastic lymphoma kinase (ALK) gene fusion. In this study, we screened consecutively resected RCCs from... -
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- Primary Central Nervous System ALK Positive Anaplastic Large Cell Lymphoma with Predominantly Leptomeningeal Involvement in an Adult
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Park JS, Park H, Park S, Kim SJ, Seol HJ, Ko YH
- KMID: 1727900
- Yonsei Med J.
- 2013 May;54(3):791-796.
- doi: 10.3349/ymj.2013.54.3.791
A 31-year-old Korean male presented with altered consciousness and severe headache. Brain MRI delineated focal leptomeningeal enhancement without any intracerebral lesions. Diagnosis was made based on a brain biopsy showing... -
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- Clinicopathologic and Molecular Characteristics of Lung Adenocarcinoma Arising in Young Patients
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Kim L, Kim KH, Yoon YH, Ryu JS, Choi SJ, Park IS, Han JY, Kim JM, Chu YC
- KMID: 1782135
- J Korean Med Sci.
- 2012 Sep;27(9):1027-1036.
- doi: 10.3346/jkms.2012.27.9.1027
Lung cancer rarely occurs in young patients. Recent studies have demonstrated that epidemiologic data are closely correlated to some molecular characteristics. We investigated the clinicopathologic characteristics of lung adenocarcinoma in... -
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- A case of inflammatory myofibroblastic tumor originated from the greater omentum in young adult
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Kye BH, Kim HJ, Kang SG, Yoo C, Cho HM
- KMID: 2324839
- J Korean Surg Soc.
- 2012 Jun;82(6):380-384.
Inflammatory myofibroblastic (IMF) tumor is a rare solid tumor that often affects children. IMF tumors occur primarily in the lung, but the tumor may affect any organ system with protean... -
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- EML4-ALK Fusion Gene in Korean Non-Small Cell Lung Cancer
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Jin G, Jeon HS, Lee EB, Kang HG, Yoo SS, Lee SY, Lee JH, Cha SI, Park TI, Kim CH, Jheon SH, Park JY
- KMID: 1120166
- J Korean Med Sci.
- 2012 Feb;27(2):228-230.
- doi: 10.3346/jkms.2012.27.2.228
A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the anaplastic lymphoma kinase (ALK) has been identified in non-small cell lung cancers (NSCLCs). Although a few studies have evaluated... -
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- Clinicopathologic Implications of ALK Gene Copy Number Gain in Non-small Cell Lung Cancer
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Yoo SB, Kim H, Xu X, Sun PL, Jin Y, Paik JH, Jheon S, Lee CT, Chung JH
- KMID: 2005739
- J Lung Cancer.
- 2011 Dec;10(2):87-93.
- doi: 10.6058/jlc.2011.10.2.87
PURPOSE: The anaplastic lymphoma kinase (ALK) gene is a potential molecular target in non-small cell lung carcinoma (NSCLC). The clinicopathologic implication of a change in the ALK gene copy number... -
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- Alteration of Alk in Neuroblastoma
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Jeon IS
- KMID: 2168926
- Clin Pediatr Hematol Oncol.
- 2011 Apr;18(1):1-7.
Neuroblastoma, one of the common pediatric solid tumor, shows variable clinical outcome depending on the prognostic factors. Several molecular changes including N-myc amplification have been elucidated as one of the... -
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- Effect of IN-1130, a Novel Transforming Growth Factor-beta Type I Receptor Kinase (ALK5) Inhibitor, on a Rat Model of Peyronie's Disease Induced by Repeated Intratunical Injections of Fibrin
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Piao S, Tumurbaatar M, Oh JH, Park SH, Suh JK, Ryu JK
- KMID: 2298783
- Korean J Androl.
- 2009 Aug;27(2):82-88.
PURPOSE: Transforming growth factor-beta1 (TGF-beta1) has been known to be involved in the pathogenesis of Peyronie's disease (PD). In the present study, we investigated the therapeutic effect of IN-1130, a... -
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- A Case of CD30 (+)/ALK (-) Primary Systemic AnaplasticLarge Cell Lymphoma with Atypical Clinical Features
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Yang YS, Jeong KH, Cho HR, Haw CR, Kim NI
- KMID: 2248083
- Korean J Dermatol.
- 2008 Oct;46(10):1419-1423.
Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin's lymphoma, and this tumor is predominantly composed of large lymphoid cells that have a strong expression of CD30. Two major... -
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- Cytomorphology and Molecular Characterization of CLTC-ALK Rearrangement in 2 Cases of ALK-Positive Diffuse Large B-cell Lymphoma with Extensive Bone Marrow Involvement
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Choung HS, Kim HJ, Kim WS, Kim K, Kim SH
- KMID: 854834
- Korean J Lab Med.
- 2008 Apr;28(2):89-94.
- doi: 10.3343/kjlm.2008.28.2.89
Aanaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma (DLBCL) is an unusual disease entity first reported in 1997 as DLBCL with expression of full-length ALK protein. The World Health Organization... -
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- Follicular Lymphoma with Monoclonal Plasma Cell Differentiation: A Case Report
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Kim HC, Lee YS, Choi JW, Kim AR, Yeom BW, Kim HK, Kim IS
- KMID: 2277686
- Korean J Pathol.
- 2006 Apr;40(2):151-155.
We present a case of recurrent follicular lymphoma with an extensive plasma cell component involving infra-auricular lymph nodes in a 64 year-old woman. Immunohistochemical staining showed a strongly positive reaction... -
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