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Longitudinal Changes of High Molecular Weight Adiponectin are Associated with Postpartum Development of Type 2 Diabetes Mellitus in Patients with Gestational Diabetes Mellitus

Lee DH, Lim JA, Kim JH, Kwak SH, Choi SH, Jang HC

Background: The influence of serial changes of adipokines on maternal glucose metabolism from pregnancy to postpartum periods in women with previous gestational diabetes mellitus (pGDM) has not been thoroughly explored....
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Adipokines in young survivors of childhood acute lymphocytic leukemia revisited: beyond fat mass

Siviero-Miachon AA, Spinola-Castro AM, Andreoni S, Lee MLdM, Calixto AR, Geloneze B, Guerra-Junior G

Purpose: This cross-sectional study evaluated the relationship between adipokines (leptin, adiponectin, visfatin, and resistin) and adiposity indexes regarding sex and cranial radiotherapy exposure among young acute lymphocytic leukemia survivors. Methods: A...
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Association between Inflammatory Biomarkers and Nutritional Status in Fatty Liver

Lim HS, Choi J, Lee B, Kim SG, Kim YS, Yoo JJ

The prevalence and progression of non-alcoholic fatty liver disease (NAFLD) is mediated via several factors correlating with hepatic necroinflammation (adipokines/cytokines). This study was performed to analyze the level of inflammatory...
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Metabolic Crosstalk between the Heart and Fat

Ferrero KM, Koch WJ

It is now recognized that the heart can behave as a true endocrine organ, which can modulate the function of other tissues. Emerging evidence has shown that visceral fat is...
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Antioxidant and antiobesity activities of oral treatment with ethanol extract from sprout of evening primrose (Oenothera laciniata) in high fat diet-induced obese mice

Kwak CS, Kim MJ, Kim SG, Park S, Kim IG, Kang HS

PURPOSE: Sprouts of evening primrose (Oenothera laciniata, OL) were reported to have high contents of flavonoids and potent antioxidant activity. This study examined the antioxidant and antiobesity activities of OL...
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Regulation of Systemic Glucose Homeostasis by T Helper Type 2 Cytokines

Kang YE, Kim HJ, Shong M

Obesity results in an inflammatory microenvironment in adipose tissue, leading to the deterioration of tissue protective mechanisms. Although recent studies suggested the importance of type 2 immunity in an anti-inflammatory...
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Effects of Omega-3 Supplementation on Adipocytokines in Prediabetes and Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Becic T, Studenik C

BACKGROUND: The objective of this systematic review and meta-analysis was to determine the effects of omega-3 supplementation on adipocytokine levels in adult prediabetic and diabetic individuals. METHODS: We searched PubMed, Medline,...
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β-Carotene Inhibits Activation of NF-κB, Activator Protein-1, and STAT3 and Regulates Abnormal Expression of Some Adipokines in 3T3-L1 Adipocytes

Cho SO, Kim MH, Kim H

BACKGROUND: Oxidative stress occurs in white adipose tissue and dysregulates the expression of adipokines secreted from adipocytes. Since adipokines influence inflammation, supplementation with antioxidants might be beneficial for preventing oxidative...
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Long-term study of the association of adipokines and glucose variability with diabetic complications

Cha JJ, Min HS, Kim K, Lee MJ, Lee MH, Kim JE, Song HK, Cha DR, Kang YS

BACKGROUND/AIMS: Recent studies have suggested an important role of adipokines in the development of insulin resistance and diabetes mellitus. The clinical relevance of adipokines on long-term outcomes in patients with...
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Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease

Boutari C, Perakakis , Mantzoros

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting 30% of the general population and 40% to 70% of obese individuals. Adipose tissue plays a crucial role in...
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Clinical Significance of Serum Adipokines according to Body Mass Index in Patients with Clinically Localized Prostate Cancer Undergoing Radical Prostatectomy

Kang M, Byun SS, Lee SE, Hong SK

PURPOSE: The aim of this study was to investigate the clinical significance of 7 circulating adipokines according to body mass index (BMI) in Korean men with localized prostate cancer (PCa)...
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The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus

Kang YE, Choung S, Lee JH, Kim HJ, Ku BJ

BACKGROUND: Slit2 is a new secreted protein from adipose tissue that improves glucose hemostasis in mice; however, there is no study about the serum levels and precise role of Slit2...
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Adipokines and Insulin Resistance According to Characteristics of Pregnant Women with Gestational Diabetes Mellitus

Jeon EJ, Hong SY, Lee JH

BACKGROUND: The aim of this study was to evaluate adipokines concentration and insulin resistance according to maternal age or obesity at pregnancy and weight change at diagnosed gestational diabetes mellitus...
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Postmenopausal Osteoporosis Is Associated with Serum Chemerin and Irisin but Not with Apolipoprotein M Levels

Engin-Üstün Y, Çağlayan EK, Göçmen A, Polat MF

OBJECTIVES: The objective of this study was to describe the levels of chemerin, irisin and apolipoprotein M (apoM) in women with postmenopausal osteoporosis. METHODS: The study included 88 women with postmenopausal...
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The Impact of Organokines on Insulin Resistance, Inflammation, and Atherosclerosis

Choi KM

Immoderate energy intake, a sedentary lifestyle, and aging have contributed to the increased prevalence of obesity, sarcopenia, metabolic syndrome, type 2 diabetes, and cardiovascular disease. There is an urgent need...
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Association of Adipokines, Insulin Resistance, Hypertension and Dyslipidemia in Patients with Psoriasis Vulgaris

Coban M, Tasli L, Turgut S, Ozkan S, Tunc Ata M, Akin F

BACKGROUND: Systemic inflammation in psoriasis causes insulin resistance and cardiovascular diseases. Adipokines are adipose-tissue-derived factors that are involved in metabolic processes. It is thought that these adipokines are associated with...
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The Effect of Abdominal Visceral Fat, Circulating Inflammatory Cytokines, and Leptin Levels on Reflux Esophagitis

Nam SY, Choi IJ, Ryu KH, Park BJ, Kim YW, Kim HB, Kim J

  • KMID: 2381256
  • J Neurogastroenterol Motil.
  • 2015 Apr;21(2):247-254.
  • doi: 10.5056/jnm14114
BACKGROUND/AIMS: Although adipocytes secrete inflammatory cytokines and adipokines, their role in reflux esophagitis is controversial. We investigated the association between visceral fat and inflammatory cytokines or adipokines in reflux esophagitis. METHODS:...
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Circulating Levels of Adipokines Predict the Occurrence of Acute Graft-versus-host Disease

Kim JS, You DB, Lim JY, Lee SE, Kim YJ, Kim HJ, Chung NG, Min CK

Currently, detecting biochemical differences before and after allogeneic stem cell transplantation (SCT) for improved prediction of acute graft-versus-host disease (aGVHD) is a major clinical challenge. In this pilot study, we...
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Causal Relationship of Non-alcoholic Fatty Liver Disease with Obesity and Insulin Resistance

Yoon HJ, Lee YH, Cha BS

Obesity has reached epidemic proportions in the world. Nonalcoholic fatty liver disease (NAFLD) affects around one-third of Western countries, with an incidence that continues to also increase in other parts...
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Is There a Link Between Obesity and Asthma?

Kim SH, Sutherland ER, Gelfand EW

Increasing epidemiological data identify a link between obesity and asthma incidence and severity. Based on experimental data, it is possible that shared inflammatory mechanisms play a role in determining this...
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