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Therapeutic Co-targeting of WEE1 and ATM Downregulates PD-L1 Expression in Pancreatic Cancer

Jin MH, Nam AR, Park JE, Bang JH, Bang YJ, Oh DY

Purpose Pancreatic cancer (PC) is one of the most lethal cancers worldwide, but there are currently no effective treatments. The DNA damage response (DDR) is under investigation for the development of...
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Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer

Nam AR, Jin MH, Park JE, Bang JH, Oh DY, Bang YJ

PURPOSE: The DNA damage response (DDR) is a multi-complex network of signaling pathways involved in DNA damage repair, cell cycle checkpoints, and apoptosis. In the case of biliary tract cancer...
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Ataxia-Telangiectasia-Mutated Protein Expression as a Prognostic Marker in Adenoid Cystic Carcinoma of the Salivary Glands

Bazarsad S, Kim JY, Zhang X, Kim KY, Lee DY, Ryu MH, Kim J

PURPOSE: Adenoid cystic carcinoma (ACC) is a high-grade malignant tumor of the salivary glands, clinically characterized by multiple recurrences and late distant metastasis. Biological markers for assessing the prognosis of...
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ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells

Wang L, Wang QT, Liu YP, Dong QQ, Hu HJ, Miao Z, Li S, Liu Y, Zhou H, Zhang TC, Ma WJ, Luo XG

PURPOSE: We previously found that the histone methyltransferase suppressor of variegation, enhancer of zeste, trithorax and myeloid-nervy-deformed epidermal autoregulatory factor-1 domain-containing protein 3 (SMYD3) is a potential independent predictive factor...
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Activation of ATM-dependent DNA Damage Signal Pathway by a Histone Deacetylase Inhibitor, Trichostatin A

Lee JS

  • KMID: 1522935
  • Cancer Res Treat.
  • 2007 Sep;39(3):125-130.
PURPOSE: Ataxia-telangiectasia mutated (ATM) kinase regulates diverse cellular DNA damage responses, including genome surveillance, cell growth, and gene expression. While the role of histone acetylation/deacetylation in gene expression is well...
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Functional Link between DNA Damage Responses and Transcriptional Regulation by ATM in Response to a Histone Deacetylase Inhibitor TSA

Lee JS

  • KMID: 1522934
  • Cancer Res Treat.
  • 2007 Sep;39(3):116-124.
PURPOSE: Mutations in the ATM (ataxia-telangiectasia mutated) gene, which encodes a 370 kd protein with a kinase catalytic domain, predisposes people to cancers, and these mutations are also linked to...
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Apoptotic Pathway Induced by Dominant Negative ATM Gene in CT-26 Colon Cancer Cells

Lee JC, Yi HK, Kim SY, Lee DY, Hwang PH, Park JW

  • KMID: 2335743
  • J Korean Pediatr Soc.
  • 2003 Jul;46(7):679-686.
PURPOSE: Ataxia telangiectasia mutated(ATM) is involved in DNA damage responses at different cell cycle checkpoints, and signalling pathways associated with regulation of apoptosis in response to ionizing radiation(IR). However, the...
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Molecular Aspects of Radiotherapy

Park HJ

  • KMID: 2200190
  • J Lung Cancer.
  • 2003 Mar;2(1):10-15.
When tumor cells are exposed to ionizing radiation, various and complicated molecular biological changes take place leading to cell death, mutation, and recovery from sublethal damage. It has been known...
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Medical Information Network Construction for the Large Scale General Hospital Information System: A Case of Seoul National University Hospital

Song SY, Beom KK, Yi CK, Lee HS, Choi JW, Kim SG

  • KMID: 2210386
  • J Korean Soc Med Inform.
  • 2001 Jun;7(2):139-147.
Recently, it becomes conspicuous that the network should have enough communication bandwidth and be organized with steadiness to operate and support hospital information system successfully. Seoul National University Hospital completed...
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Induced Apoptosis of Cancer Cells by Antisense ATM Gene Therapy

Yi HK, Chang SH, Lee DY, Kim JS, Hwang RH

  • KMID: 2175105
  • J Korean Cancer Assoc.
  • 2000 Apr;32(2):339-349.
PURPOSE: Recently cloned AT gene mutated (ATM) in ataxia telangiectasia is involved in DNA damage response at different cell cycle checkpoints and also appears to have a wide role in signal transduction....
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Reconstruction of Large Bone Defect after Bone and Soft Tissue Tumor Resection , using Jeat - Treated Autogenous Isotrophic Bone Graft

Lee JS, Jeon DG, Kim HY, Kang YH, Chung DH, Lee SY

To fill the large bone defect after bone and soft tissue tumor resection, there are several options such as tumor prosthesis, bone cement with intramedullary nail, autogenous bone graft and...
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