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Trichomonas vaginalis Metalloproteinase Induces mTOR Cleavage of SiHa Cells

Quan JH, Choi IW, Yang JB, Zhou W, Cha GH, Zhou Y, Ryu JS, Lee YH

Trichomonas vaginalis secretes a number of proteases which are suspected to be the cause of pathogenesis; however, little is understood how they manipulate host cells. The mammalian target of rapamycin...
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The Intrinsic Relation between the Hydrogel Structure and In Vivo Performance of Hyaluronic Acid Dermal Fillers: A Comparative Study of Four Typical Dermal Fillers

Zhou W, Hou S, Deng S, Peng Y, Fu W, Zhou Y, Yang J, Peng C

BACKGROUND: Hyaluronic acid dermal fillers are composed of cross-linked viscoelastic particles with high biocompatibility. The performance of the fillers is determined by the viscoelastic properties of particles and the connecting...
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Two-Dimensional Shear Wave Elastography Predicts Liver Fibrosis in Jaundiced Infants with Suspected Biliary Atresia: A Prospective Study

Chen H, Zhou L, Liao B, Cao Q, Jiang H, Zhou W, Wang G, Xie X

Objective: This study aimed to evaluate the role of preoperative two-dimensional (2D) shear wave elastography (SWE) in assessing the stages of liver fibrosis in patients with suspected biliary atresia (BA)...
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Evaluation of Protective Immune Response Induced by a DNA Vaccine Encoding GRA8 against Acute Toxoplasmosis in a Murine Model

Chu JQ, Huang S, Ye W, Fan XY, Huang R, Ye SC, Yu CY, Wu WY, Zhou Y, Zhou W, Lee YH, Quan JH

Toxoplasma gondii is an apicomplexan zoonotic protozoan parasite that infects most species of warm-blooded animals, including humans. The heavy incidence and severe or lethal damage caused by T. gondii infection...
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Hospitalization Due to Asthma Exacerbation: A China Asthma Research Network (CARN) Retrospective Study in 29 Provinces Across Mainland China

Lin J, Xing B, Tang H, Yang L, Yuan Y, Gu Y, Chen P, Liu X, Zhang J, Liu H, Wang C, Zhou W, Sun D, Chen Y, Chen Z, Huang M, Lin Q, Hu C, Yang X, Huo J, Ye X, Zhou X, Jiang P, Zhang W, Huang Y, Dai L, Liu R, Cai S, Xu J, Zhou J, on behalf of China Asthma Research Network

PURPOSE: Details of patients hospitalized for asthma exacerbation in mainland China are lacking. To improve disease control and reduce economic burden, a large sample survey among this patient population is...
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Genome Architecture and Its Roles in Human Copy Number Variation

Chen L, Zhou W, Zhang L, Zhang F

Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic...
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The Role of PI3K/AKT Pathway and NADPH Oxidase 4 in Host ROS Manipulation by Toxoplasma gondii

Choi HG, Gao FF, Zhou W, Sun PR, Yuk JM, Lee YH, Cha GH

Dendritic cell is one of the first innate immune cell to encounter T. gondii after the parasite crosses the host intestinal epithelium. T. gondii requires intact DC as a carrier...
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Erector spinae plane block for spinal surgery: a systematic review and meta-analysis

Liang X, Zhou W, Fan Y

Background: Although the erector spinae plane block has been used in various truncal surgical procedures, its clinical benefits in patients undergoing spinal surgery remain controversial. The aim of this meta-analysis...
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Kinetics of IL-23 and IL-12 Secretion in Response to Toxoplasma gondii Antigens from THP-1 Monocytic Cells

Quan JH, Zhou W, Cha GH, Choi IW, Shin DW, Lee YH

IL-23 and IL-12 are structurally similar and critical for the generation of efficient cellular immune responses. Toxoplasma gondii induces a strong cell-mediated immune response. However, little is known about IL-23...
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Regulation of Gut Microbiota Disrupts the Glucocorticoid Receptor Pathway and Inflammation-related Pathways in the Mouse Hippocampus

Rao X, Liu L, Wang H, Yu Y, Li W, Chai T, Zhou W, Ji P, Song J, Wei H, Xie P

An increasing number of studies have recently indicated the important effects of gut microbes on various functions of the central nervous system. However, the underlying mechanisms by which gut microbiota regulate...
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Dipenyleneiodonium Induces Growth Inhibition of Toxoplasma gondii through ROS Induction in ARPE-19 Cells

Sun PR, Gao FF, Choi HG, Zhou W, Yuk JM, Kwon J, Lee YH, Cha GH

Based on the reactive oxygen species (ROS) regulatory properties of diphenyleneiodonium (DPI), we investigated the effects of DPI on host-infected T. gondii proliferation and determined specific concentration that inhibit the...
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EMP3 Overexpression in Primary Breast Carcinomas is not Associated with Epigenetic Aberrations

Zhou W, Jiang Z, Li X, Xu F, Liu Y, Wen P, Kong L, Hou M, Yu J

Epithelial membrane protein 3 (EMP3) is a trans-membrane signaling molecule with important roles in the regulation of apoptosis, differentiation and invasion of cancer cells, but the detailed is largely still...
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Naloxone Postconditioning Alleviates Rat Myocardial Ischemia Reperfusion Injury by Inhibiting JNK Activity

Xia A, Xue Z, Wang W, Zhang T, Wei T, Sha X, Ding Y, Zhou W

To investigate the alteration of c-Jun N-terminal kinase (JNK) activity after myocardial ischemia reperfusion injury (MIRI) and further explore the effect of naloxone postconditioning on MIRI. Forty male Sprague Dawley...
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CXCL-13 Regulates Resistance to 5-Fluorouracil in Colorectal Cancer

Zhang G, Luo X, Zhang W, Chen E, Xu J, Wang F, Cao G, Ju Z, Jin D, Huang X, Zhou W, Song Z

Purpose 5-Fluorouracil (5-Fu) is used as a conventional chemotherapy drug in chemotherapy for patients with advanced colorectal cancer, but many patients still suffer from treatment failure due to 5-Fu resistance. Emerging observations revealed...
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Disease burden of prostate cancer from 2014 to 2019 in the United States: estimation from the Global Burden of Disease Study 2019 and Medical Expenditure Panel Survey

Lin S, Lin D, Li Y, Zhong L, Zhou W, Wu Y, Xie C, Luo S, Huang X, Xu X, Weng X

OBJECTIVES: The aim of this study was to evaluate the disease burden of prostate cancer (PC) and assess key influencing factors associated with the disease expenditures of PC in the...
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Impact of Older Age Adiposity on Incident Diabetes: A Community-Based Cohort Study in China

Chen A, Zhou W, Hou J, Nevill A, Ding Y, Wan Y, Jester R, Qin X, Hu Z, Chen R

Background: Obesity classifications vary globally and the impact of older age adiposity on incident diabetes has not been well-studied. Methods: We examined a random sample of 2,809 participants aged ≥60 years...
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Optimizing the Imaging Protocol for Ex Vivo Coronary Artery Wall Using High-Resolution MRI: An Experimental Study on Porcine and Human

Yang J, Li T, Cui X, Zhou W, Li X, Zhang X

OBJECTIVE: To optimize the MR imaging protocol for coronary arterial wall depiction in vitro and characterize the coronary atherosclerotic plaques. MATERIALS AND METHODS: MRI examination was prospectively performed in ten porcine...
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Comparison of Six Automated Immunoassays With Isotope-Diluted Liquid Chromatography-Tandem Mass Spectrometry for Total Thyroxine Measurement

Yu S, Zhou W, Cheng X, Meng Q, Li H, Hou L, Lu J, Xie S, Cheng Q, Zhang C, Qiu L

BACKGROUND: Accurate serum total thyroxine (TT4) measurement is important for thyroid disorder diagnosis and management. We compared the performance of six automated immunoassays with that of isotope-diluted liquid chromatography-tandem mass...
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Analysis of 12 Chinese Patients with Proline-to-Leucine Mutation at Codon 102-Associated Gerstmann-Sträussler-Scheinker Disease

Wang J, Xiao K, Zhou W, Shi Q, Dong XP

BACKGROUND AND PURPOSE: Gerstmann-Sträussler-Scheinker disease (GSS) with a proline-to-leucine mutation at codon 102 (P102L) in the PRNP gene is the most frequently reported GSS subtype worldwide. This study aimed to...
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Retrospective Molecular Epidemiology Study of PD-L1 Expression in Patients with EGFR-Mutant Non-small Cell Lung Cancer

Cho JH, Zhou W, Choi YL, Sun JM, Choi H, Kim TE, Dolled-Filhart M, Emancipator K, Rutkowski , Kim J

PURPOSE: Data are limited on programmed death ligand 1 (PD-L1) expression in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: We retrospectively evaluated the relationship between...
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