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Shikonin ameliorates salivary gland damage and inflammation in a mouse model of Sjögren’s syndrome by modulating MAPK signaling pathway

Guo W, Wang X, Sun C, Wang J, Wang T

Sjögren syndrome (SS) is a systemic inflammatory autoimmune disease that involves exocrine glands. Shikonin is extracted from comfrey, which is conventionally used as an anti-tumor, antibacterial, and antiviral drug in...
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Life Cycle of Dermacentor everestianus Hirst, 1926 (Acari: Ixodidae) under Laboratory Conditions

Jin S, Wang T, Li T, Liu M, Jia Q, Yang X, Wang H, Yu Z, Liu J

This study investigated the development characteristics of Dermacentor everestianus under laboratory conditions. The time taken for D. everestianus to complete the whole life cycle was 110.2 days on average, and...
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Dissecting Causal Relationships Between Gut Microbiota, Blood Metabolites, and Stroke: A Mendelian Randomization Study

Wang Q, Dai H, Hou T, Hou Y, Wang T, Lin H, Zhao Z, Li M, Zheng R, Wang S, Lu J, Xu Y, Liu R, Ning G, Wang W, Bi Y, Zheng J, Xu M

Background and Purpose We investigated the causal relationships between the gut microbiota (GM), stroke, and potential metabolite mediators using Mendelian randomization (MR). Methods We leveraged the summary statistics of GM (n=18,340...
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Potassium Channelopathies and Gastrointestinal Ulceration

Han J, Lee SH, Giebisch G, Wang T

Potassium channels and transporters maintain potassium homeostasis and play significant roles in several different biological actions via potassium ion regulation. In previous decades, the key revelations that potassium channels and...
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MiR-182-5p Mediated by Exosomes Derived From Bone Marrow Mesenchymal Stem Cell Attenuates Inflammatory Responses by Targeting TLR4 in a Mouse Model of Myocardial Infraction

Sun C, Li W, Li Y, Chen J, An H, Zeng G, Wang T, Guo Y, Wang C

Exosomes derived from mesenchymal stem cells (MSCs) could protect against myocardial infarction (MI). TLR4 is reported to play an important role in MI, while microRNA-182-5p (miR-182-5p) negatively regulates TLR4 expression....
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Dynamic Frequency of Blood CD4+CD25+ Regulatory T Cells in Rats with Collagen-induced Arthritis

Wang T, Li J, Jin Z, Wu F, Li Y, Wang X, Zhou H, Zhou Q

CD4+CD25+ regulatory T cells (CD4+CD25+ Tregs) have been shown to play a regulatory or suppressive role in the immune response and are possibly relevant to the pathogenesis of autoimmune diseases....
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Influence of Peanut Cultivars and Environmental Conditions on the Diversity and Community Composition of Pod Rot Soil Fungi in China

Wang M, Chen M, Yang Z, Chen N, Chi X, Pan L, Wang T, Yu S, Guo X

Peanut yield and quality are seriously affected by pod rot pathogens worldwide, especially in China in recent years. The goals of this study are to analyze the structure of fungal...
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Posterior Apophyseal Ring Fracture in Adult Lumbar Disc Herniation: An 8-Year Experience in Minimally Invasive Surgical Management of 48 Cases

Yuan S, Wu Q, Zang L, Fan N, Du P, Wang A, Wang T, Si F, Li J, Kong X

Objective: Posterior apophyseal ring fracture (PARF) is an uncommon disorder that is usually accompanied by lumbar disc herniation (LDH). The aim of this study to describe the 8-year experience of...
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Effect of Diet and Water Intake on Aquaporin 2 Function

Kim JM, Kim TH, Wang T

Appropriate control of diet and water intake is important for maintaining normal blood pressure, fluid and electrolyte homeostasis in the body. It is relatively understood that the amount of sodium...
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The Work Experience of Newly Recruited Male Nurses during COVID-19: A Qualitative Study

Zhou H, Wang X, Du R, Cheng X, Zheng K, Dong S, Henri J, Chen C, Wang T

Purpose This study was to investigate the work experience of newly recruited male nurses during the COVID-19 pandemic. Methods With a phenomenological approach, this qualitative study was adopted semistructured interviews by phone or...
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Long Non-Coding RNA RMRP Contributes to Sepsis-Induced Acute Kidney Injury

Zhang X, Huang Z, Wang Y, Wang T, Li J, Xi P

Purpose: This study aimed to explore the role of the long non-coding RNA (lncRNA) RNA component of mitochondrial RNAase P (RMRP) in sepsis-induced acute kidney injury (AKI). Materials and Methods: Venous...
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Evaluation of the Potential Association between NOS Gene Polymorphisms (iNOS G-954C and eNOS G894T) and Psoriasis

Duan X, Cheng Y, Gao L, Li L, Wang T, Zhang M

No abstract available.
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Outcomes of Anti-CD19 CAR-T Treatment of Pediatric B-ALL with Bone Marrow and Extramedullary Relapse

Wan X, Yang X, Yang F, Wang T, Ding L, Song L, Miao Y, Wang X, Ma Y, Luo C, Tang J, Gu L, Chen J, Tang Y, Lu J, Li B

Purpose Anti-CD19 chimeric antigen receptor T-cell immunotherapy (19CAR-T) has achieved impressive clinical results in adult and pediatric relapsed/refractory (r/r) B-lineage acute lymphoblastic leukemia (B-ALL). However, the application and effect of CAR-T...
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Transcriptome Sequencing Reveals the Potential Mechanisms of Modified Electroconvulsive Therapy in Schizophrenia

Peng W, Tan Q, Yu M, Wang P, Wang T, Yuan J, Liu D, Chen D, Huang C, Tan Y, Liu K, Xiang B, Liang X

Objective Schizophrenia (SCZ) is one of the most common and severe mental disorders. Modified electroconvulsive therapy (MECT) is the most effective therapy for all kinds of SCZ, and the underlying...
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Inhibition of MicroRNA-92a Improved Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats via Suppressing Oxidative Stress and Endothelial Dysfunction

Tang Z, Song J, Yu Z, Cui K, Ruan Y, Liu Y, Wang T, Wang S, Liu J, Yang J

Purpose: To determine whether microRNA could be a therapy target of erectile dysfunction (ED) and the underlying mechanisms. Materials and Methods: Eight-week-old fasting male SD rats were intraperitoneally injected with streptozotocin...
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Postmenopausal Hypertension and Sodium Sensitivity

Kim JM, Kim TH, Lee HH, Lee SH, Wang T

  • KMID: 2325447
  • J Menopausal Med.
  • 2014 Apr;20(1):1-6.
It has been well established that women generally have lower incidence rates of hypertension than men at similar ages and these differences may vary with age. It also has been...
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Spermatogenesis of Male Patients with Congenital Hypogonadotropic Hypogonadism Receiving Pulsatile Gonadotropin-Releasing Hormone Therapy Versus Gonadotropin Therapy: A Systematic Review and Meta-Analysis

Wei C, Long G, Zhang Y, Wang T, Wang S, Liu J, Ma D, Liu X

Purpose: Pulsatile gonadotropin-releasing hormone (GnRH) therapy and gonadotropin therapy (GT) were widely used for male patients with congenital hypogonadotropic hypogonadism (CHH), but their efficacy was not well compared before. We...
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Is Folate Status a Risk Factor for Asthma or Other Allergic Diseases?

Wang T, Zhang HP, Zhang X, Liang ZA, Ji YL, Wang G

PURPOSE: It is controversial whether folate status is a risk factor for the development of asthma or other allergic diseases. This study was conducted to investigate whether indirect or direct...
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Relaxin-2 Prevents Erectile Dysfunction by Cavernous Nerve, Endothelial and Histopathological Protection Effects in Rats with Bilateral Cavernous Nerve Injury

Liu K, Sun T, Xu W, Song J, Chen Y, Ruan Y, Li H, Cui K, Zhang Y, Feng Y, Pan J, Liang E, Xin Z, Wang T, Wang S, Liu J, Luan Y

Purpose Cavernous nerve injury induced erectile dysfunction (ED) is a refractory complication with high incidence in person under radical prostatectomy. Studies have shown that relaxin-2 (RLX-2) plays a vital role of...
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The Association of GSDMB and ORMDL3 Gene Polymorphisms With Asthma: A Meta-Analysis

Zhao CN, Fan Y, Huang JJ, Zhang HX, Gao T, Wang C, Wang T, Hou LF

PURPOSE: ORM1-like 3 (ORMDL3) belongs to a highly conserved protein family which is anchored as transmembrane protein in the endoplasmic reticulum. Gasdermin B (GSDMB) is adjacent to ORMDL3 on chromosome...
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