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Changes of CA1 Excitability in Rats after Prenatal Methylazoxymethanol Treatment

Jang SY, Choi IS, Cho JH, Jang IS, Lee MG, Choi BJ

  • KMID: 1512936
  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):13-17.
Experimentally induced cortical disorganization exhibits many anatomical features which are characteristic of cortical malformations in children with early-onset epilepsy. We used an immunocytochemical technique and extracellular field potential recordings from...
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Metformin Enhances Leptin Sensitivity in Aged Rats

Kim SR, Park SY, Kim JY, Kim YW

  • KMID: 1512934
  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):1-6.
To evaluate whether metformin restores leptin sensitivity in aged rats with leptin resistance, we measured leptin sensitivity in aged (2 year old) and adult (5 month old) rats after 4...
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Lysophosphatidylcholine Attenuates Endothelium-dependent Relaxation Responses through Inhibition of ACh-induced Endothelial [Ca2+]i Increase

Kwon SC, Lee YH, Nam T, Ahn DS

  • KMID: 1512938
  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):25-30.
Lysophosphatidylcholine (LPC), which accumulates in atherosclerotic arteries, has been reported to inhibit endothelium-dependent relaxation (EDR) in many different species. However, the underlying mechanism of LPC-induced inhibition of EDR is still...
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Fluoxetine Modulates Corticostriatal Synaptic Transmission through Postsynaptic Mechanism

Cho HS, Choi SJ, Kim KJ, Lee HH, Cho YJ, Kim SY, Sung KW

  • KMID: 1512939
  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):31-38.
Fluoxetine, widely used for the treatment of depression, is known to be a selective serotonin reuptake inhibitor (SSRI), however, there are also reports that fluoxetine has direct effects on several...
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Melittin-induced Nociceptive Responses are Alleviated by Cyclooxygenase-1 Inhibitor

Kim J, Shin HK, Lee KH

  • KMID: 1512941
  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):45-50.
Melittin-induced pain model has been known to be very useful for the study of pain mechanism. Melittin-induced nociceptive responses are reported to be modulated by the changes in the activity...
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Differential Functional Expression of Clotrimazole-sensitive Ca2+-activated K+ Current in Bal-17 and WEHI-231 Murine B Lymphocytes

Zheng H, Ko JH, Nam JH, Earm YE, Kim SJ

  • KMID: 1512937
  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):19-24.
The intermediate conductance Ca2+-activated K+ channels (SK4, IKCa1) are present in lymphocytes, and their membrane expression is upregulated by various immunological stimuli. In this study, the activity of SK4 was...
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Promoting Effect of Hydrogen Peroxide on 1-Methyl-4-phenylpyridinium-induced Mitochondrial Dysfunction and Cell Death in PC12 Cells

Lee DH, Lee CS

  • KMID: 1512942
  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):51-58.
The promoting effect of hydrogen peroxide (H2O2) against the cytotoxicity of 1-methyl-4-phenylpyridinium (MPP+) in differentiated PC12 cells was assessed by measuring the effect on the mitochondrial membrane permeability. Treatment of...
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pH-mediated Regulation of Pacemaker Activity in Cultured Interstitial Cells of Cajal

Kim BJ, Lee JH, So I, Kim KW

  • KMID: 1512935
  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):7-11.
Interstitial cells of Cajal (ICCs) are pacemakers in gastrointestinal tracts, regulating rhythmicity by activating nonselective cation channels (NSCCs). In the present study, we investigated the general characteristics and pH-mediated regulation...
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Short-Term High Expression of Interferon-Alpha Modulates Progression of Type 1 Diabetes in NOD Mice

Park MK, Seo SY, Hong SH, Kim HJ, Park EJ, Kim DK, Lee HJ

  • KMID: 1512940
  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):39-44.
Type I diabetes (T1D) is an organ-specific autoimmune disease caused by the T cell-mediated destruction of the insulin-producing beta cells in the pancreatic islets. The onset of T1D is the...
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