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Toll-like receptor 4/nuclear factor-kappa B pathway is involved in radicular pain by encouraging spinal microglia activation and inflammatory response in a rat model of lumbar disc herniation

Zhu L, Huang Y, Hu Y, Tang Q, Zhong Y

Background: Lumbar disc herniation (LDH) is a common cause of radicular pain, but the mechanism is not clear. In this study, we investigated the engagement of toll-like receptor 4 (TLR4)...
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Melatonin Attenuates Mitochondrial Damage in Aristolochic AcidInduced Acute Kidney Injury

Sun J, Pan J, Liu Q, Cheng J, Tang Q, Ji Y, Cheng K, wang R, Liu L, Wang D, Wu N, Zheng X, Li J, Zhang X, Zhu Z, Ding Y, Zheng F, Li J, Zhang Y, Yuan Y

Aristolochic acid (AA), extracted from Aristolochiaceae plants, plays an essential role in traditional herbal medicines and is used for different diseases. However, AA has been found to be nephrotoxic and...
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