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The Calcium and Voltage Clocks in Sinoatrial Node Automaticity

Joung B, Ogawa M, Lin SF, Chen PS

Recent evidence indicates that the voltage (cyclic activation and deactivation of membrane ion channels) and Ca2+ clocks (rhythmic spontaneous sarcoplasmic reticulum Ca2+ release) jointly regulate sinoatrial node (SAN) automaticity. Since...
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The Role of the Calcium and the Voltage Clocks in Sinoatrial Node Dysfunction

Joung B, Chen PS, Lin SF

Recent evidence indicates that the voltage clock (cyclic activation and deactivation of membrane ion channels) and Ca2+ clocks (rhythmic spontaneous sarcoplasmic reticulum Ca2+ release) jointly regulate sinoatrial node (SAN) automaticity....
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Cervical Vagal Nerve Stimulation Activates the Stellate Ganglion in Ambulatory Dogs

Rhee KS, Hsueh CH, Hellyer JA, Park HW, Lee YS, Garlie J, Onkka P, Doytchinova AT, Garner JB, Patel J, Chen LS, Fishbein M, Everett T, Lin SF, Chen PS

BACKGROUND AND OBJECTIVES: Recent studies showed that, in addition to parasympathetic nerves, cervical vagal nerves contained significant sympathetic nerves. We hypothesized that cervical vagal nerve stimulation (VNS) may capture the...
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