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Gene Therapy for Muscular Dystrophies: Progress and Challenges

Park KS, Oh D

Muscular dystrophies are groups of inherited progressive diseases of the muscle caused by mutations of diverse genes related to normal muscle function. Although there is no current effective treatment for...
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Mononeuropathy Multiplex in a Patient with Chronic Active Hepatitis B

Nam TS, Lee SH, Park MS, Choi KH, Kim JT, Choi SM, Kim BC, Kim MK, Cho KH

BACKGROUND: Mononeuropathy multiplex is a rare complication during the course of chronic he-patitis B, despite various neuropathies following acute hepatitis B having been reported previously. CASE REPORT: A 30-year-old man presented...
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Behavioral Changes as the Earliest Clinical Manifestation of Progressive Supranuclear Palsy

Han HJ, Kim H, Park JH, Shin HW, Kim GU, Kim DS, Lee EJ, Oh HE, Park SH, Kim YJ

BACKGROUND: The clinical and pathological heterogeneity of progressive supranuclear palsy (PSP) is well established. Even with a well-defined clinical phenotype and a thorough laboratory workup, PSP can be misdiagnosed, especially...
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Takotsubo Cardiomyopathy Following Cerebral Infarction Involving the Insular Cortex

Cho HJ, Kim HY, Han SH, Kim HJ, Moon YS, Oh J

BACKGROUND: Takotsubo cardiomyopathy is characterized by clinical features similar to those of acute myocardial ischemia, but without angiographic evidence of obstructive coronary artery disease. We present a patient with takotsubo...
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There is No Association between Cardiovascular Autonomic Dysfunction and Peripheral Neuropathy in Chronic Hemodialysis Patients

Stamboulis E, Voumvouraki K, Zambelis T, Andrikopoulou A, Vlahakos D, Tsivgoulis A, Rallis D, Tsivgoulis G

BACKGROUND AND PURPOSE: The potential association between the severity of autonomic dysfunction and peripheral neuropathy has not been extensively investigated, with the few studies yielding inconsistent results. We evaluated the...
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Prehospital Notification from the Emergency Medical Service Reduces the Transfer and Intra-Hospital Processing Times for Acute Stroke Patients

Bae HJ, Kim DH, Yoo NT, Choi JH, Huh JT, Cha JK, Kim SK, Choi JS, Kim JW

BACKGROUND AND PURPOSE: There is little information available about the effects of Emergency Medical Service (EMS) hospital notification on transfer and intrahospital processing times in cases of acute ischemic stroke. METHODS:...
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Melatonin Potentiates the Neuroprotective Properties of Resveratrol Against Beta-Amyloid-Induced Neurodegeneration by Modulating AMP-Activated Protein Kinase Pathways

Kwon KJ, Kim HJ, Shin CY, Han SH

BACKGROUND AND PURPOSE: Recent studies have demonstrated that resveratrol (RSV) reduces the incidence of age-related macular degeneration, Alzheimer's disease (AD), and stroke, while melatonin (MEL) supplementation reduces the progression of...
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Cost-Effectiveness of Recombinant Tissue Plasminogen Activator in the Management of Acute Ischemic Stroke: A Systematic Review

Jung KT, Shin DW, Lee KJ, Oh M

BACKGROUND AND PURPOSE: This work was undertaken to review the current cost-effectiveness analysis data on thrombolysis by intravenous (IV) therapy with recombinant tissue plasminogen activator (rtPA) for acute ischemic stroke. METHODS:...
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