- Positive Symptoms in Antipsychotic-naïve Schizophrenia are Associated with Increased Body Mass Index after Treatment
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Lin SH, Tseng HH, Tsai HC, Chi MH, Lee IH, Chen PS, Chen KC, Yang YK
- KMID: 2513401
- Clin Psychopharmacol Neurosci.
- 2021 Feb;19(1):155-159.
- doi: 10.9758/cpn.2021.19.1.155
Objective: Weight gain is an important risk factor for morbidity and mortality among patients with schizophrenia. We speculated that positive symptoms, related to dopaminergic hyperactivity and altered mesolimbic function, are... -
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- Holistic Consideration of Patients with Schizophrenia to Improve Medication Adherence and Outcomes
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Lee LT, Chen KC, Chang WH, Chen PS, Lee IH, Yang YK
- KMID: 2171043
- Clin Psychopharmacol Neurosci.
- 2015 Aug;13(2):138-143.
- doi: 10.9758/cpn.2015.13.2.138
Although several algorithms have been applied to treat patients with schizophrenia, their clinical use remains still limited, because most emphasize the prescription of antipsychotics. A new algorithm with a more... -
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- Increased Readmission Risk and Healthcare Cost for Delirium Patients without Immediate Hospitalization in the Emergency Department
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Ma IC, Chen KC, Chen WT, Tsai HC, Su CC, Lu RB, Chen PS, Chang WH, Yang YK
- KMID: 2428969
- Clin Psychopharmacol Neurosci.
- 2018 Nov;16(4):398-406.
- doi: 10.9758/cpn.2018.16.4.398
OBJECTIVE: Hospitalization of patients with delirium after visiting the emergency department (ED) is often required. However, the readmission risk after discharge from the ED should also be considered. This study... -
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- Altered Auditory P300 Performance in Parents with Attention Deficit Hyperactivity Disorder Offspring
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Chi MH, Chu CL, Lee IH, Hsieh YT, Chen KC, Chen PS, Yang YK
- KMID: 2464717
- Clin Psychopharmacol Neurosci.
- 2019 Nov;17(4):509-516.
- doi: 10.9758/cpn.2019.17.4.509
OBJECTIVE: Altered event-related potential (ERP) performances have been noted in attention deficit hyperactivity disorder (ADHD) patients and reflect neurocognitive dysfunction. Whether these ERP alterations and correlated dysfunctions exist in healthy... -
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- Serotonin Modulates the Correlations between Obsessive-compulsive Trait and Heart Rate Variability in Normal Healthy Subjects: A SPECT Study with [ 123 I]ADAM and Heart Rate Variability Measurement
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Kuo CY, Chen KC, Lee IH, Tseng HH, Chiu NT, Chen PS, Yang YK, Chang WH
- KMID: 2530462
- Clin Psychopharmacol Neurosci.
- 2022 May;20(2):271-278.
- doi: 10.9758/cpn.2022.20.2.271
Objective: The impact of serotonergic system on obsessive-compulsive disorder (OCD) is well studied. However, the correlation between OC presentations and autonomic nervous system (ANS) is still unclear. Furthermore, whether the... -
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- Wavebreak Mechanism During Ventricular Fibrillation in Isolated Swine Right Ventricle
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Lee MH, Qu Z, Weiss JN, Garfinkel , Karagueuzian HS, Chen PS
- KMID: 2093772
- Korean Circ J.
- 2000 Nov;30(11):1404-1416.
- doi: 10.4070/kcj.2000.30.11.1404
BACKGROUND: Several different patterns of wavebreak have been described by mapping of the tissue surface during fibrillation. However, it is not clear whether these surface patterns are caused by multiple... -
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- The Effects of Excitation-Contraction Uncouplers on the Dynamics of Ventricular Fibrillation in Isolated Swine Right Ventricles
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Lee MH, Karagueuzian HS, Chen PS
- KMID: 2093785
- Korean Circ J.
- 2000 Dec;30(12):1515-1523.
- doi: 10.4070/kcj.2000.30.12.1515
BACKGROUND: Whether or not the excitation-contraction (EC) uncoupler, diacetyl monoxime (DAM) and cytochalacin D (Cyto D) alter the ventricular fibrillation activation patterns is unclear. METHODS: We recorded single cell action... -
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- ALDH2 Gene: Its Effects on the Neuropsychological Functions in Patients with Opioid Use Disorder Undergoing Methadone Maintenance Treatment
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Lee PW, Wang TY, Chang YH, Lee SY, Chen SL, Wang ZC, Chen PS, Chu CH, Huang SY, Tzeng NS, Lee IH, Chen KC, Yang YK, Hong JS, Lu RB
- KMID: 2502135
- Clin Psychopharmacol Neurosci.
- 2020 Feb;18(1):136-144.
- doi: 10.9758/cpn.2020.18.1.136
Objective: Patients with opioid use disorder (OUD) have impaired attention, inhibition control, and memory function. The aldehyde dehydrogenase 2 (ALDH2 ) gene has been associated with OUD and ALDH2 gene... -
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- Central Pontine Myelinolysis in a Normonatremic Patient with Depression
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Liu YC, Yang YK, Chen PS, Chang WH
- KMID: 2519566
- Clin Psychopharmacol Neurosci.
- 2021 Aug;19(3):564-567.
- doi: 10.9758/cpn.2021.19.3.564
A 76-year-old male presented with a recurrent depressive episode, an unsteady gait and cognitive impairment. Extensive blood tests, including hemogram, biochemical tests, folic acid, vitamin B12, and thyroid hormone, showed... -
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- Dextromethorphan Protect the Valproic Acid Induced Downregulation of Neutrophils in Patients with Bipolar Disorder
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Lu RB, Chang YH, Lee SY, Wang TY, Cheng SL, Chen PS, Yang YK, Hong JS, Chen SL
- KMID: 2502136
- Clin Psychopharmacol Neurosci.
- 2020 Feb;18(1):145-152.
- doi: 10.9758/cpn.2020.18.1.145
Objective: Valproic acid (VPA) is an anticonvulsant and commonly long term used as a mood stabilizer for patients with mood disorders. However its chronic effects on the hematological changes were... -
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- Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [99mTc] TRODAT-1
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Lu TH, Lin SH, Tseng HH, Yang YK, Chiu NT, Chen PS
- KMID: 2536489
- Clin Psychopharmacol Neurosci.
- 2022 Nov;20(4):768-772.
- doi: 10.9758/cpn.2022.20.4.768
Objective: Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear. Methods: Fifty-three... -
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- Harm Avoidance is Correlated with the Reward System in Adult Patients with Attention Deficit Hyperactivity Disorder: A Functional Magnetic Resonance Imaging Study
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Lu TH, Lin SH, Chi MH, Chu CL, Yang DY, Chang WH, Chen PS, Yang YK
- KMID: 2539654
- Clin Psychopharmacol Neurosci.
- 2023 Feb;21(1):99-107.
- doi: 10.9758/cpn.2023.21.1.99
Objective: Hypoactivity in the reward system among patients with attention deficit hyperactivity disorder (ADHD) is a well-known phenomenon. Whether the activity in the reward pathway is related to harm avoidance,... -
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- The Calcium and Voltage Clocks in Sinoatrial Node Automaticity
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Joung B, Ogawa M, Lin SF, Chen PS
- KMID: 1490696
- Korean Circ J.
- 2009 Jun;39(6):217-222.
- doi: 10.4070/kcj.2009.39.6.217
Recent evidence indicates that the voltage (cyclic activation and deactivation of membrane ion channels) and Ca2+ clocks (rhythmic spontaneous sarcoplasmic reticulum Ca2+ release) jointly regulate sinoatrial node (SAN) automaticity. Since... -
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- Cervical Vagal Nerve Stimulation Activates the Stellate Ganglion in Ambulatory Dogs
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Rhee KS, Hsueh CH, Hellyer JA, Park HW, Lee YS, Garlie J, Onkka P, Doytchinova AT, Garner JB, Patel J, Chen LS, Fishbein M, Everett T, Lin SF, Chen PS
- KMID: 2297882
- Korean Circ J.
- 2015 Mar;45(2):149-157.
- doi: 10.4070/kcj.2015.45.2.149
BACKGROUND AND OBJECTIVES: Recent studies showed that, in addition to parasympathetic nerves, cervical vagal nerves contained significant sympathetic nerves. We hypothesized that cervical vagal nerve stimulation (VNS) may capture the... -
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- Function and Dysfunction of Human Sinoatrial Node
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Joung B, Chen PS
- KMID: 2389124
- Korean Circ J.
- 2015 May;45(3):184-191.
- doi: 10.4070/kcj.2015.45.3.184
Sinoatrial node (SAN) automaticity is jointly regulated by a voltage (cyclic activation and deactivation of membrane ion channels) and Ca2+ clocks (rhythmic spontaneous sarcoplasmic reticulum Ca2+ release). Using optical mapping... -
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- The Role of the Calcium and the Voltage Clocks in Sinoatrial Node Dysfunction
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Joung B, Chen PS, Lin SF
- KMID: 1779654
- Yonsei Med J.
- 2011 Mar;52(2):211-219.
- doi: 10.3349/ymj.2011.52.2.211
Recent evidence indicates that the voltage clock (cyclic activation and deactivation of membrane ion channels) and Ca2+ clocks (rhythmic spontaneous sarcoplasmic reticulum Ca2+ release) jointly regulate sinoatrial node (SAN) automaticity.... -
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- Association between ABCB1 Polymorphisms and Antidepressant Treatment Response in Taiwanese Major Depressive Patients
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Chang HH, Chou CH, Yang YK, Lee IH, Chen PS
- KMID: 2171025
- Clin Psychopharmacol Neurosci.
- 2015 Dec;13(3):250-255.
- doi: 10.9758/cpn.2015.13.3.250
OBJECTIVE: The multidrug resistance 1 (ABCB1, MDR1) gene, encoding P-glycoprotein, is extensively distributed and expressed in various tissues, such as a blood-brain barrier transporter. P-glycoprotein plays an important role in... -
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- The Interaction of Oxytocin and Social Support, Loneliness, and Cortisol Level in Major Depression
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Tsai TY, Tseng HH, Chi MH, Chang HH, Wu CK, Yang YK, Chen PS
- KMID: 2464714
- Clin Psychopharmacol Neurosci.
- 2019 Nov;17(4):487-494.
- doi: 10.9758/cpn.2019.17.4.487
OBJECTIVE: Loneliness is a specific risk factor for depressive symptoms and suicidal behavior. The present study examined whether the serum oxytocin level would interact with social support and buffers loneliness... -
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- Arrhythmogenic Gene Change and Nerve Sprouting after Acute Myocardial Infarction in Mice
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Oh YS, Kim JH, Choi YS, Park HW, Lee DH, Shin WS, Youn HJ, Lee MY, Chung WS, Rho TH, Kim JH, Chen PS, Choi KB
- KMID: 2093975
- Korean Circ J.
- 2007 Sep;37(9):399-407.
- doi: 10.4070/kcj.2007.37.9.399
BACKGROUND AND OBJECTIVES: Myocardial infarction (MI) elicits nerve sprouting. However, the time course and spatial distribution of this nerve sprouting and its relationship to the expression of neurotrophic factors is... -
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