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Delay of Treatment Initiation Does Not Adversely Affect Survival Outcome in Breast Cancer

Yoo TK, Han W, Moon HG, Kim J, Lee JW, Kim MK, Lee E, Kim J, Noh DY

PURPOSE: Previous studies examining the relationship between time to treatment and survival outcome in breast cancer have shown inconsistent results. The aim of this study was to analyze the overall...
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Responses to Overdiagnosis in Thyroid Cancer Screening among Korean Women

Lee S, Lee YY, Yoon HJ, Choi E, Suh M, Park B, Jun JK, Kim Y, Choi KS

PURPOSE: Communicating the harms and benefits of thyroid screening is necessary to help individuals decide on whether or not to undergo thyroid cancer screening. This study was conducted to assess...
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What Is the Ideal Tumor Regression Grading System in Rectal Cancer Patients after Preoperative Chemoradiotherapy?

Kim SH, Chang HJ, Kim DY, Park JW, Baek JY, Kim SY, Park SC, Oh JH, Yu A, Nam BH

PURPOSE: Tumor regression grade (TRG) is predictive of therapeutic response in rectal cancer patients after chemoradiotherapy (CRT) followed by curative resection. However, various TRG systems have been suggested, with subjective...
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Systemic Treatments for Metastatic Renal Cell Carcinoma: 10-Year Experience of Immunotherapy and Targeted Therapy

Kim SH, Park WS, Kim SH, Joung JY, Seo HK, Lee KH, Chung J

PURPOSE: The purpose of this study is to compare the outcomes of first-line systemic targeted therapy (TT) and immunotherapy (IT) in patients with metastatic renal cell carcinoma (mRCC). MATERIALS AND METHODS:...
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TERT Promoter Mutations and Tumor Persistence/Recurrence in Papillary Thyroid Cancer

Myung JK, Kwak BK, Lim JA, Lee MC, Kim MJ

PURPOSE: A telomerase reverse transcriptase (TERT) promoter mutation was identified in thyroid cancer. This TERT promoter mutation is thought to be a prognostic molecular marker, because its association with tumor...
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Cost Effectiveness of Colorectal Cancer Screening Interventions with Their Effects on Health Disparity Being Considered

Lee KS, Park EC

PURPOSE: The purpose of this study was to evaluate the cost effectiveness of colorectal cancer screening interventions with their effects on health disparity being considered. MATERIALS AND METHODS: Markov cohort simulation...
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Concurrent Chemoradiotherapy Versus Chemotherapy Alone for Unresectable Locally Advanced Pancreatic Cancer: A Retrospective Cohort Study

Choi Y, Oh DY, Kim K, Chie EK, Kim TY, Lee KH, Han SW, Im SA, Kim TY, Ha SW, Bang YJ

PURPOSE: The optimal treatment strategy for locally advanced pancreatic cancer (LAPC), particularly the role of concurrent chemoradiotherapy (CCRT), remains debatable. We compared the clinical outcomes of CCRT and palliative chemotherapy...
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Effect of Helicobacter pylori Eradication on Long-Term Survival after Distal Gastrectomy for Gastric Cancer

Kim YI, Cho SJ, Lee JY, Kim CG, Kook MC, Ryu KW, Kim YW, Choi IJ

PURPOSE: Negative Helicobacter pylori status has been identified as a poor prognostic factor for survival in gastric cancer (GC) patients who underwent surgery. The aim of this study was to...
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Relationship between Salt Preference and Gastric Cancer Screening: An Analysis of a Nationwide Survey in Korea

Shin JY, Kim J, Choi KS, Suh M, Park B, Jun JK

PURPOSE: Epidemiological studies have demonstrated an association between excessive salt intake and gastric cancer risk, and this potential risk increases the need for adequate gastric cancer screening in individuals with...
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Splenomegaly and Its Associations with Genetic Polymorphisms and Treatment Outcome in Colorectal Cancer Patients Treated with Adjuvant FOLFOX

Kim MJ, Han SW, Lee DW, Cha Y, Lee KH, Kim TY, Oh DY, Kim SH, Im SA, Bang YJ, Kim TY

PURPOSE: Splenomegaly is a clinical surrogate of oxaliplatin-induced sinusoidal obstruction syndrome (SOS). We investigated development of splenomegaly and its association with treatment outcome and genetic polymorphisms following adjuvant 5-fluorouracil, leucovorin,...
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Dexamethasone Inhibits TGF-β1-Induced Cell Migration by Regulating the ERK and AKT Pathways in Human Colon Cancer Cells Via CYR61

Han S, Bui NT, Ho MT, Kim YM, Cho M, Shin DB

PURPOSE: One of the features in cancer development is the migration of cancer cells to form metastatic lesions. CYR61 protein promotes migration and the epithelial-mesenchymal transition in several cancer cell...
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Chronological Changes of Quality of Life in Long-Term Survivors after Gastrectomy for Gastric Cancer

Yu W, Park KB, Chung HY, Kwon OK, Lee SS

PURPOSE: A few studies have prospectively evaluated changes in quality of life (QoL) after surgery in short-term survivors; however, no prospective study has evaluated the longitudinal changes in QoL in...
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Changing Patterns of Primary Treatment in Korean Men with Prostate Cancer Over 10 Years: A Nationwide Population Based Study

Park J, Suh B, Shin DW, Hong JH, Ahn H

PURPOSE: We investigated changing patterns of primary treatment in Korean men with prostate cancer (PC) and impact of sociodemographic factors on treatment choice from a nationwide cohort over 10 years. MATERIALS...
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Incidence and Survival of Childhood Cancer in Korea

Park HJ, Moon EK, Yoon JY, Oh CM, Jung KW, Park BK, Shin HY, Won YJ

PURPOSE: An epidemiologic study of childhood cancer would provide useful information on cancer etiology and development of management guidelines. MATERIALS AND METHODS: Data from the Korea National Cancer Incidence Database were...
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Analysis of BRIP1 Variants among Korean Patients with BRCA1/2 Mutation-Negative High-Risk Breast Cancer

Kim H, Cho DY, Choi DH, Jung GH, Shin I, Park W, Huh SJ, Nam SJ, Lee JE, Gil WH, Kim SW

PURPOSE: The aim of the current study is to assess the spectrum of genetic variation in the BRIP1 gene among Korean high-risk breast cancer patients who tested negative for the...
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Variation in Practice Patterns of Korean Radiation Oncologists for Spine Metastasis between 2009 and 2014

Yu JI, Park HC, Ahn YC, Chung Y, Koom WS, Song SY

PURPOSE: The Korean Society of Radiation Oncologists (KOSRO) conducted the Patterns of Care Study (PCS) of radiotherapy (RT) for spine metastases in 2009. The current study was conducted to investigate...
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The Clinical Status of Radiation Therapy in Korea in 2009 and 2013

Kang JK, Kim MS, Jang WI, Kim HJ, Cho CK, Yoo HJ, Seo YS, Paik EK, Cha YJ

PURPOSE: The purpose of this study is to estimate the clinical status of radiation therapy (RT) in Korea. MATERIALS AND METHODS: We analyzed open claims data from the Health Insurance Review...
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In Vitro Adenosine Triphosphate-Based Chemotherapy Response Assay as a Predictor of Clinical Response to Fluorouracil-Based Adjuvant Chemotherapy in Stage II Colorectal Cancer

Kwon HY, Kim IK, Kang J, Sohn SK, Lee KY

PURPOSE: We evaluated the usefulness of the in vitro adenosine triphosphate-based chemotherapy response assay (ATP-CRA) for prediction of clinical response to fluorouracil-based adjuvant chemotherapy in stage II colorectal cancer. MATERIALS AND...
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Cisplatin, Gemcitabine, and Lapatinib as Neoadjuvant Therapy for Muscle-Invasive Bladder Cancer

Narayan V, Mamtani R, Keefe S, Guzzo T, Malkowicz , Vaughn DJ

PURPOSE: We sought to investigate the safety and efficacy of gemcitabine, cisplatin, and lapatinib (GCL) as neoadjuvant therapy in patients with muscle-invasive bladder cancer (MIBC) planned for radical cystectomy. MATERIALS AND...
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Clinical Characteristics and Continued Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Administration in EGFR-mutated Non-Small Cell Lung Cancer with Skeletal Metastasis

Hong SH, Kim YS, Lee JE, Kim IH, Kim SJ, Han D, Yoo IR, Chung YG, Kim YH, Lee KY, Kang JH

PURPOSE: The aim of this study was to analyze clinical characteristics of skeletal metastasis in epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) and treatment outcomes of...
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