Yonsei Med J.  1988 Mar;29(1):66-71. 10.3349/ymj.1988.29.1.66.

Photochemotherapy-induced Lentigines on a Vitiliginous Patch Electron Microscopic Observations

• Lee KH
• Bang DS
• Lee WS

• KMID: 693113
• DOI: http://doi.org/10.3349/ymj.1988.29.1.66

Abstract

Patients with vitiligo seem be less prone to the development of lentigines as a side effect of long-term photochemotherapy than do psoriatics. An 8-year-old boy who had a vitiliginous patch on his left thigh, had been receiving photochemotherapy since he was 2 years old. At the age of 3, multiple star-shaped brownish macules developed at the site of treatment. Photochemotherapy was continued until the patient was 6 year old, at which time no improvement in the vitiligo was seen, so photochemotherapy was discontinued. Now 2 years after treatment the lentigines still persist. On electron microscopic examination, the melanocytes showed two patterns of cell death: coagulative necrosis and apotosis together with atypical cytoplasmic and melanosomal alterations.

Keyword

Vitiligo; photochemotherapy; lentigines; coagulative necrosis; apoptosis

MeSH Terms

Case Report
Child
Human
Lentigo/*etiology/pathology
Male
Melanocytes/ultrastructure
Microscopy, Electron
PUVA Therapy/*adverse effects
Vitiligo/drug therapy