J Korean Med Sci.
2003 Aug;18(4):592-594. 10.3346/jkms.2003.18.4.592.
Hemophagocytic Syndrome Associated with Kikuchi's Disease
- Affiliations
-
- 1Department of Pediatrics, College of Medicine, Pusan National University, Busan, Korea. pse0731@hanmail.net
- 2Department of Surgical Pathology, College of Medicine, Pusan National University, Busan, Korea.
- 3Department of Clinical Pathology, College of Medicine, Pusan National University, Busan, Korea.
- KMID: 648915
- DOI: http://doi.org/10.3346/jkms.2003.18.4.592
Abstract
- A 13-yr-old female was admitted to our hospital with fever, seizure, and cervical lym-phadenopathy. Laboratory data showed pancytopenia, elevation of serum transaminase, lactate dehydrogenase, triglyceride, and ferritin levels. Lymph node biopsy revealed features of Kikuchi's disease and there were signs of histiocytosis and hemophagocytic phenomenon in bone marrow. She recovered after treatment with intravenous immunoglobulin and corticosteroids therapy. Hemophagocytic syndrome can be associated with Kikuchi's disease especially in childhood and seems to have a less aggressive clinical course and better prognosis.
MeSH Terms
-
Adolescent
Adrenal Cortex Hormones/therapeutic use
Biopsy
Bone Marrow Cells/metabolism/pathology
Female
Ferritin/blood
Histiocytic Necrotizing Lymphadenitis/*complications/*diagnosis
Histiocytosis, Non-Langerhans-Cell/*complications/*diagnosis
Human
Immunoglobulins/metabolism/therapeutic use
L-Lactate Dehydrogenase/blood
Lymph Nodes/pathology
Lymphatic Diseases/diagnosis
Necrosis
Pancytopenia/diagnosis
Prognosis
Transaminases/blood
Triglycerides/blood
Cited by 2 articles
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A Case of Kikuchi Fujimoto's Disease Accompanied by Hemophagocytic Lymphohistiocytosis
Young-Sang Byoun, Byeong-Bae Park, Sung-Heon Song, Soo-Yuck Park, Seong-Min Chung, Ji-Sun Lee, Sun-Min Kim, Yeon-Jae Kim, Ju-Hyun Lee, Ji-Won Ryu, Jung-Hye Choi, Young-Yiul Lee, In-Soon Kim
Korean J Hematol. 2009;44(4):325-329. doi: 10.5045/kjh.2009.44.4.325.Hemophagocytic lymphohistiocytosis with recurrent Kikuchi-Fujimoto disease
Sang Min Lee, Young Tae Lim, Kyung Mi Jang, Mi Jin Gu, Jong Ho Lee, Jae Min Lee
Yeungnam Univ J Med. 2020;38(3):245-250. doi: 10.12701/yujm.2020.00654.
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