J Korean Med Sci.  1999 Jun;14(3):319-322. 10.3346/jkms.1999.14.3.319.

Rheumatoid arthritis associated with myelodysplastic syndrome: a case report

• Nam EJ
• Kang YM
• Kang HR
• Kim JH
• Rho HJ
• Lee MK
• Hyun SH
• Kim GW
• Lee JM
• Kim NS

• KMID: 646312
• DOI: http://doi.org/10.3346/jkms.1999.14.3.319

Abstract

Myelodysplastic syndromes (MDS) are a group of refractory anemias resulting from a clonal stem cell disorder often associated with cytogenetic abnormalities. There is increasing recognition of immunological abnormalities in patients with MDS, including defective B- and T-cell function, hyper- or hypogammaglobulinemia and monoclonal gammopathy. MDS have been associated with Sjogren's syndrome, polymyalgia rheumatica, relapsing polychondritis and systemic lupus erythematosus. Although there may be various rheumatologic features, including acute arthritis in MDS, chronic inflammatory arthritis is uncommonly combined. There have been a few reports that described cases of rheumatoid arthritis (RA) concurrent with MDS, but advanced rheumatoid arthritis with typical joint deformities has rarely been reported. We report a case of rheumatoid arthritis with atlantoaxial subluxation combined with refractory anemia in a 31-year-old woman.

Keyword

Myelodysplastic syndromes; Rheumatoid arthritis

MeSH Terms

Adult
Arthritis, Rheumatoid/radiography
Arthritis, Rheumatoid/pathology
Arthritis, Rheumatoid/complications*
Arthritis, Rheumatoid/blood
Case Report
Female
Follow-Up Studies
Human
Myelodysplastic Syndromes/pathology
Myelodysplastic Syndromes/complications*
Myelodysplastic Syndromes/blood