J Korean Surg Soc.  2011 Apr;80(4):241-244. 10.4174/jkss.2011.80.4.241.

The indices of body size and aggressiveness of papillary thyroid carcinoma

• Kim JY
• Jung EJ
• Jeong SH
• Jeong CY
• Ju YT
• Lee YJ
• Hong SC
• Choi SK
• Ha WS
• Park ST

• KMID: 1820013
• DOI: http://doi.org/10.4174/jkss.2011.80.4.241

Abstract

PURPOSE
The incidence of papillary thyroid carcinoma (PTC) is increasing worldwide. Positive associations between indices of body size and thyroid cancer have been reported. However, the relationships to cancer severities and/or behaviors are uncertain.
METHODS
We performed a retrospective analysis of the data of patients who underwent total thyroidectomy due to PTC. The epidemiologic factor and pathologic report after operation were determined based on chart review. The relationships between indices of body size and these parameters were assessed.
RESULTS
Positive association between body mass index and T stage was found, but it was not statically significant. In neck lymph node metastasis, the group with metastasis had a tendency for larger mean height and weight, but significant difference was found only in height. However, in the multivariate analysis, the age and size of nodules were only identified as independent risk factors of neck lymph node metastasis (P = 0.000 and 0.019).
CONCLUSION
There was no independent association between indices of body size and stages of PTC in patients who underwent total thyroidectomy.

Keyword

Body size; Height; Weight; Body mass index; Papillary thyroid carcinoma

MeSH Terms

Body Mass Index
Body Size
Carcinoma
Epidemiologic Factors
Factor IX
Humans
Incidence
Lymph Nodes
Multivariate Analysis
Neck
Neoplasm Metastasis
Retrospective Studies
Risk Factors
Thyroid Gland
Thyroid Neoplasms
Thyroidectomy
Carcinoma
Factor IX
Thyroid Neoplasms

Reference

1. Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA. 2006. 295:2164–2167.

2. Mazzaferri EL. Management of a solitary thyroid nodule. N Engl J Med. 1993. 328:553–559.

3. Hay ID, Bergstralh EJ, Goellner JR, Ebersold JR, Grant CS. Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1779 patients surgically treated at one institution during 1940 through 1989. Surgery. 1993. 114:1050–1057.

4. Cady B. Papillary carcinoma of the thyroid gland: treatment based on risk group definition. Surg Oncol Clin N Am. 1998. 7:633–644.

5. Loh KC, Greenspan FS, Gee L, Miller TR, Yeo PP. Pathological tumor-node-metastasis (pTNM) staging for papillary and follicular thyroid carcinomas: a retrospective analysis of 700 patients. J Clin Endocrinol Metab. 1997. 82:3553–3562.

6. Engeland A, Tretli S, Akslen LA, Bjørge T. Body size and thyroid cancer in two million Norwegian men and women. Br J Cancer. 2006. 95:366–370.

7. Goodman MT, Kolonel LN, Wilkens LR. The association of body size, reproductive factors and thyroid cancer. Br J Cancer. 1992. 66:1180–1184.

8. Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008. 371:569–578.

9. Iribarren C, Haselkorn T, Tekawa IS, Friedman GD. Cohort study of thyroid cancer in a San Francisco Bay area population. Int J Cancer. 2001. 93:745–750.

10. Mack WJ, Preston-Martin S, Bernstein L, Qian D. Lifestyle and other risk factors for thyroid cancer in Los Angeles County females. Ann Epidemiol. 2002. 12:395–401.

11. Dal Maso L, La Vecchia C, Franceschi S, Preston-Martin S, Ron E, Levi F, et al. A pooled analysis of thyroid cancer studies. V. Anthropometric factors. Cancer Causes Control. 2000. 11:137–144.

12. Ron E, Kleinerman RA, Boice JD Jr, LiVolsi VA, Flannery JT, Fraumeni JF Jr. A population-based case-control study of thyroid cancer. J Natl Cancer Inst. 1987. 79:1–12.

13. Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA. 2010. 303:235–241.

14. World Cancer Research Fund/American Institute for Cancer Research. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. 2007. Washigton, DC: Americal Institute for Cancer Research.

15. Paes JE, Hua K, Nagy R, Kloos RT, Jarjoura D, Ringel MD. The relationship between body mass index and thyroid cancer pathology features and outcomes: a clinicopathological cohort study. J Clin Endocrinol Metab. 2010. 95:4244–4250.

16. Edge SB, Byrd DR, Compton CC, Frits AG, Greene FL, Trotti A. AJCC cancer staging manual. 2010. 7th ed. New York: Springer.

17. Leitzmann MF, Brenner A, Moore SC, Koebnick C, Park Y, Hollenbeck A, et al. Prospective study of body mass index, physical activity and thyroid cancer. Int J Cancer. 2010. 126:2947–2956.

18. Sung J, Song YM, Lawlor DA, Smith GD, Ebrahim S. Height and site-specific cancer risk: a cohort study of a Korean adult population. Am J Epidemiol. 2009. 170:53–64.