Korean J Otorhinolaryngol-Head Neck Surg.  2024 Apr;67(4):234-239. 10.3342/kjorl-hns.2023.00794.

Dupilumab in the Treatment of Eosinophilic Otitis Media: A Case Report

• Kim JK
• Jin MH
• Kim MW
• Kwak MY

• KMID: 2554650
• DOI: http://doi.org/10.3342/kjorl-hns.2023.00794

Abstract

Eosinophilic otitis media (EOM) differs from classic chronic otitis media as it is a refractory disease with the accumulation of eosinophils in thick mucinous middle ear effusion and mucosa. A 66-year-old male with a history of asthma, chronic sinusitis with polyposis, nasal polyposis, and multiple sets of ventilation tubes was presented to our center for the management of hearing loss and otorrhea. He had a history of consistent otorrhea and hearing loss even with the ventilation tube insertions and medical treatment. Both systemic and intratympanic steroid was administered, but the effect was insignificant and other systemic adverse effects occurred. Finally, the otologic symptoms including hearing loss and otorrhea improved after being given a Dupilumab injection. This case report discusses Dupilumab treatment resulting in remission in a patient suffering from refractory EOM.

Keyword

Dupilumab; Eosinophil; Hearing loss; Otitis media; Steroids