J Pathol Transl Med.  2024 Mar;58(2):98-101. 10.4132/jptm.2024.03.06.

What’s new in thyroid pathology 2024: updates from the new WHO classification and Bethesda system

• Bychkov A
• Jung CK

• KMID: 2553478
• DOI: http://doi.org/10.4132/jptm.2024.03.06

Abstract

In line with the release of the 5th edition WHO Classification of Tumors of Endocrine Organs (2022) and the 3rd edition of the Bethesda System for Reporting Thyroid Cytopathology (2023), the field of thyroid pathology and cytopathology has witnessed key transformations. This digest brings to the fore the refined terminologies, newly introduced categories, and contentious methodological considerations pivotal to the updated classification.

Figure

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  Fig. 1. Differentiated high-grade thyroid carcinoma. (A) High-grade FTC with necrosis (left) and mitosis (upper right). (B) High-grade PTC with mitotic activity.

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  Fig. 2. BRAF-mutant ATC (A) detected by VE1 immunostaining (B).

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  Fig. 3. High-grade MTC is identified by combination of mitotic activity (A, center) and tumor necrosis (B).

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  Fig. 4. AUS subtypes. AUS-nuclear atypia with mild nuclear changes (A) versus AUS-other (B).

Reference

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