Korean J Psychosom Med.  2023 Dec;31(2):165-172. 10.22722/KJPM.2023.31.2.165.

Relationships of Peripheral Inflammatory Marker With Suicide Attempt History

• Oh SH
• Kim SJ
• Shin SH
• Oh HS
• Lee JC
• Im WY
• Lee NH

• KMID: 2550613
• DOI: http://doi.org/10.22722/KJPM.2023.31.2.165

Abstract

objectives
：The purpose of this study is to determine whether there is a significant difference in the neutro-phil-to-lymphocyte ratio and platelet-to-lymphocyte ratio according to the history of suicide attempt in patients with psychiatric diseases.
Methods
：A medical record review was conducted on patients who had been hospitalized in Konyang University Hospital since 2021-03-01 to 2023-02-28 to collect demographic and clinical characteristics. T-test for continuous variables and Chi-square test for categorical variables were performed to determine demographic differences according to the history of suicide attempt, and the ANCOVA test was performed to compare the average value of peripheral inflammatory marker according to the history of suicide attempt with gender and age as co-variates. One-way variance analysis was performed to determine whether the number of suicide attempt causes significant difference of the peripheral inflammatory marker.
Results
：The final analysis target of this study was 266 patients, 101 had history of suicide attempt, and 165 had no history of suicide attempt. The neutrophil-to-lymphocyte ratio (p<0.001) and platelet-to-lymphocyte ratio (p<0.001) were higher in patients with the history of suicide attempt than patients without the history of suicide attempt, but the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were not significantly in-creased depending on the serial increase of number of suicide attempts.
Conclusions
：This study suggests that peripheral inflammatory markers are meaningful and easily accessible indicators for predicting the risk of suicide attempt in psychiatric patients. We expect that prospective follow-up study will be conducted with more subjects and controlled potential confounding variables.

Keyword

Suicide; Inflammation; Neutrophil; Lymphocyte; Platelet