J Pathol Transl Med.  2023 Jul;57(4):238-241. 10.4132/jptm.2023.06.07.

Metastatic choroidal melanoma in the breast: a case report and review of the literature

• Abudalu L
• Malhotra V
• Nasir N
• Titi S

• KMID: 2544331
• DOI: http://doi.org/10.4132/jptm.2023.06.07

Abstract

The breast is an unusual site for metastases, accounting for less than 2% of malignant breast lesions but include those from malignant melanomas, carcinomas, sarcomas, and lymphomas from various organs. We diagnosed a very rare case of metastatic choroidal melanoma for a 67-year-old female who presented with a right breast lump and who had been previously diagnosed with choroidal melanoma-monosomy 3 in 2017. To the best of our knowledge, only five such cases have been published so far, with one in a male patient.

Keyword

Breast neoplasms; Uveal melanoma; Metastasis

Figure

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  Fig. 1. Ultrasound of the right breast showing an irregular hyperechoic mass.

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  Fig. 2. Core needle biopsy of the breast showed tumor with adjacent benign fibrofatty tissue.

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  Fig. 3. Core needle biopsy of the breast showed infiltrating tumor with spindle cell differentiation: (A) low power and (B) high power.

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  Fig. 4. Tumors cells showed positive reaction for (A) SOX10 (Patchy), (B) Melan-A, (C) human melanoma black 45, and (D) S100 (focal) immunostains.

Reference

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