J Neurogastroenterol Motil.  2022 Apr;28(2):303-311. 10.5056/jnm20216.

Three-dimensional High-resolution Anorectal Manometry in Children With Non-retentive Fecal Incontinence

• Banasiuk M
• Dziekiewicz M
• Dobrowolska M
• Skowrońska B
• Dembiński Ł
• Banaszkiewicz A

• KMID: 2528045
• DOI: http://doi.org/10.5056/jnm20216

Abstract

Background/Aims
Three-dimensional high-resolution anorectal manometry (3D-HRAM) is a precise tool to assess the function of the anorectum. Our aim is to evaluate children diagnosed with non-retentive fecal incontinence (NRFI) using 3D-HRAM.
Methods
In all children diagnosed with NRFI, manometric parameters and 3-dimensional reconstructions of the anal canal subdivided into 8 segments were recorded. All data were compared to raw data that were obtained from asymptomatic children, collected in our laboratory and published previously (C group).
Results
Forty children (31 male; median age, 8 years; range, 5-17) were prospectively included in the study. Comparison of the NRFI group and C group revealed lower values of mean resting pressure (74.4 mmHg vs 89.2 mmHg, P < 0.001) and maximum squeeze pressure (182 mmHg vs 208.5 mmHg, P = 0.018) in the NRFI group. In the NRFI group, the thresholds of sensation, urge and discomfort (40 cm³ , 70 cm³ , and 140 cm³ , respectively) were significantly higher than those in the C group (20 cm³ , 30 cm³ , and 85 cm³ , respectively; P < 0.001). In the NRFI group, 62.5% presented a mean resting pressure above the fifth percentile, and 82.5% of patients presented a maximum squeeze pressure above the fifth percentile. The comparisons between segments obtained from these patients and those obtained from the C group revealed several segments with significantly decreased pressure values in the NRFI group.
Conclusions
Our study demonstrated lower pressure parameters in children with NRFI. In patients with normal resting pressures, 3D-HRAM may reveal segments with decreased pressures, which may play a potential role in the pathomechanism of incontinence.

Keyword

Child; Fecal incontinence; High-resolution manometry