J Korean Med Assoc.  2019 Aug;62(8):459-465. 10.5124/jkma.2019.62.8.459.

Therapeutic efficacy of Mirena in gynecologic disease

• Lee JY

• KMID: 2455381
• DOI: http://doi.org/10.5124/jkma.2019.62.8.459

Abstract

The levonorgestrel-releasing intrauterine system (LNG-IUS) was originally developed as a method of contraception and was first marketed in Finland in 1990. In Korea, the only LNG-IUS approved for non-contraceptive use is Mirena, a T-shaped device with a vertical stem containing a reservoir of 52 mg of levonorgestrel, which releases 20 µg of levonorgestrel per day. The device's strong local effects on the endometrium benefit women with gynecological conditions such as heavy menstrual bleeding, dysmenorrhea, leiomyoma, adenomyosis, and endometriosis. There is also evidence to support its role in endometrial protection during postmenopausal estrogen therapy and in the treatment of endometrial hyperplasia without atypia and, possibly, early endometrial cancer. Because of its effectiveness, safety, and high patient satisfaction, the LNG-IUS will continue to provide important benefits in women's reproductive health.

Keyword

Mirena; Levonorgestrel releasing-intrauterine system; Menorrhagia; Dysmenorrhea; Endometrial protection

MeSH Terms

Adenomyosis
Contraception
Dysmenorrhea
Endometrial Hyperplasia
Endometrial Neoplasms
Endometriosis
Endometrium
Estrogens
Female
Finland
Genital Diseases, Female*
Hemorrhage
Humans
Korea
Leiomyoma
Levonorgestrel*
Menorrhagia
Methods
Patient Satisfaction
Reproductive Health
Estrogens
Levonorgestrel

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