Yonsei Med J.  2017 Mar;58(2):266-271. 10.3349/ymj.2017.58.2.266.

Stem Cell Therapy for Neonatal Disorders: Prospects and Challenges

• Chang YS
• Ahn SY
• Sung S
• Park WS

• KMID: 2427113
• DOI: http://doi.org/10.3349/ymj.2017.58.2.266

Abstract

Despite recent advances in neonatal medicine, neonatal disorders, such as bronchopulmonary dysplasia and intraventricular hemorrhage in preterm neonates and hypoxic ischemic encephalopathy in term neonates, remain major causes of mortality and morbidities. Promising preclinical research results suggest that stem cell therapies represent the next breakthrough in the treatment of currently intractable and devastating neonatal disorders with complex multifactorial etiologies. This review focuses primarily on the potential role of stem cell therapy in the above mentioned neonatal disorders, highlighting the results of human clinical trials and the challenges that remain to be addressed for their safe and successful translation into clinical care of newborn infants.

Keyword

Mesenchymal stem cells; bronchopulmonary dysplasia; intraventricular hemorrhage; hypoxic ischemic encephalopathy; newborn

MeSH Terms

Bronchopulmonary Dysplasia/*therapy
Cerebral Hemorrhage/*therapy
Genetic Therapy/*methods/trends
Humans
Hypoxia-Ischemia, Brain/*therapy
Infant, Newborn
*Infant, Premature
Stem Cell Transplantation/*methods/trends

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