J Korean Soc Echocardiogr.  1995 Jul;3(1):17-22. 10.4250/jkse.1995.3.1.17.

A Clinical Study on the Antihypertensive Effect, and the Changes of Left Ventricular Mass and Left Ventricular Diastolic Function of Perindopril

• Jung WS
• Park JW
• Youn HJ
• Lee MY
• Park JC
• Chae JS
• Kim JH
• Choi KB
• Hong SJ

• KMID: 2410427
• DOI: http://doi.org/10.4250/jkse.1995.3.1.17

Abstract

BACKGROUND
Perindopril, a new second-generation angiotensin converting enzyme inhinbitor was administered in essential hypertensive patients in order to observe the clinical effects. METHOD: The changes of blood pressure. heart rate, clinical laboratory examinations, side effects, electrocardiogram, echocardiographic left ventricular mass, and left ventricular diastolic function were evaluated before and after 4-8mg of perindopril for 12 weeks administration in 20 essential hypertensive patients(male 4, female 16 ; mean age 57±12 years).
RESULTS
1) The average of blood pressure of 20 subjects were systolic 172.5±17.4mmHg and diastolic 106.4±7.7mmHg before treatment which were lowered to 142.8±16.0mmHg and 88.6±8.6mmHg respectively ofter 12 weeks(p < 0.05). There was no significant reduction in geart rate. 2) The average of left ventricular mass before treatment was 287.5±61g, which was lowered to 251.3±39.7g. But there was no significant difference in left ventricular mass before and after treatment(P>0.05). There was no significant difference in left ventricular diastolic dysfunction before and after treatment. 3) Side effects were 2 cases of mild dry cough and 2 headache.
CONCLUSION
Perindopril may be an effective initial single antihypertensive agent for the treatment of essential hypertentsion with little side effects.

Keyword

Perindopril; Hypertension; Left ventricular mass

MeSH Terms

Blood Pressure
Clinical Study*
Cough
Echocardiography
Electrocardiography
Female
Headache
Heart Rate
Humans
Hypertension
Methods
Peptidyl-Dipeptidase A
Perindopril*
Peptidyl-Dipeptidase A
Perindopril

Reference

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