J Korean Ophthalmol Soc.  2018 Jan;59(1):73-80. 10.3341/jkos.2018.59.1.73.

Longitudinal Evaluation of Retinal Structure in Patients with Traumatic Optic Neuropathy Using Optical Coherence Tomography

• Hwang SH
• Lee JY
• Chi M

• KMID: 2401681
• DOI: http://doi.org/10.3341/jkos.2018.59.1.73

Abstract

PURPOSE
We used optical coherence tomography (OCT) for longitudinal evaluation of structural changes in the peripapillary retinal nerve fiber layer (RNFL), the macular ganglion cell-inner plexiform layer (GC-IPL), and the macula in patients with traumatic optic neuropathy.
METHODS
From May 2012 to April 2015, the medical records of 20 patients with monocular traumatic optic neuropathy who were followed up for over 6 months were retrospectively analyzed. Best-corrected visual acuity was checked and Cirrus high-definition optical coherence tomography (HD-OCT) was used to measure the thicknesses of the peripapillary RNFL, macular GC-IPL, and macula of both eyes at the first visit (within 4 weeks after trauma), at 10 and 24 weeks after trauma, and at the final visits. The differences over time in the parameters of the traumatic and fellow eyes were analyzed.
RESULTS
The final best-corrected visual acuities of the traumatic and fellow eyes differed significantly from those at the first visit (p = 0.007). The average thicknesses of the peripapillary RNFL, the macular GC-IPL, and the macula differed significantly between the traumatic and fellow eyes commencing 10 weeks after trauma (p < 0.001, p = 0.002, p = 0.003, respectively).
CONCLUSIONS
Significant changes in visual acuity preceded structural changes in the retina. Objective assessment of retinal structural changes using OCT yields helpful information on the clinical course of patients with traumatic optic neuropathy.

Keyword

Ganglion cell-inner plexiform layer; Optical coherence tomography; Retinal nerve fiber layer; Traumatic optic neuropathy

MeSH Terms

Ganglion Cysts
Humans
Medical Records
Nerve Fibers
Optic Nerve Injuries*
Retina
Retinaldehyde*
Retrospective Studies
Tomography, Optical Coherence*
Visual Acuity
Retinaldehyde

Figure

• 

  Figure 1 Linear progression of mean retinal nerve fiber layer (RNFL) thickness (µm) of traumatic eye and the fellow eye. Mean RNFL thickness showed significant difference at 10 weeks, 24 weeks after trauma and final follow-up. *Wilcoxon signed rank test (p < 0.05).

• 

  Figure 2 Linear progression of mean Ganglion Cell and Internal plexiform layer (GC-IPL) thickness (µm) of traumatic eye and the fellow eye. Mean GC-IPL thickness showed significant difference at 10 weeks, 24 weeks after trauma and final follow-up. *Wilcoxon signed rank test (p < 0.05).

• 

  Figure 3 Linear progression of mean macular thickness (µm) of traumatic eye and the fellow eye. Mean macular thickness showed significant difference at 10 weeks, 24 weeks after trauma and final follow-up. *Wilcoxon signed rank test (p < 0.05).

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