Nucl Med Mol Imaging.
2016 Dec;50(4):358-361. 10.1007/s13139-015-0385-6.
Systemic Immune Response to Vaccination on FDG-PET/CT
- Affiliations
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- 1Department of Imaging, Dana-Farber Cancer Institute and Department of Radiology, Brigham and Women's Hospital, 450 Brookline Avenue, Boston, MA 02215, USA. hjacene@partners.org
- 2Department of RadiationOncology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
- KMID: 2386161
- DOI: http://doi.org/10.1007/s13139-015-0385-6
Abstract
- A patient with newly diagnosed right lung cancer had transient ¹â¸F-fluorodeoxyglucose (FDG)-avid left axillary lymph nodes and intense splenic FDG uptake on positron emission tomography (PET)/computed tomography (CT). History revealed that the patient received a leftsided influenza vaccine 2-3 days before the examination. Although inflammatory FDG uptake in ipsilateral axillary nodes is reported, to our knowledge, this is the first report of visualization of the systemic immune response in the spleen related to the influenza vaccination on FDG-PET/ CT. The history, splenic uptake and time course on serial FDG-PET/CT helped to avoid a false-positive interpretation for progressing lung cancer and alteration of the radiation therapy plan.
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