Tissue Eng Regen Med.
2017 Feb;14(1):1-14. 10.1007/s13770-016-0001-6.
Artificial Bone via Bone Tissue Engineering: Current Scenario and Challenges
- Affiliations
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- 1Department of Biosciences and Technology, Defence Institute of Advanced Technology, Girinagar, Pune, MS 411025, India.
- 2Center for Biomaterials, Cellular and Molecular Theranostics, VIT University, Vellore 632104, India.
- 3Center for Interdisciplinary Research, D. Y. Patil University, Kolhapur 416006, India. kadamsachin@gmail.com
- KMID: 2371099
- DOI: http://doi.org/10.1007/s13770-016-0001-6
Abstract
- Bone provides mechanical support, and flexibility to the body as a structural frame work along with mineral storage, homeostasis, and blood pH regulation. The repair and/or replacement of injured or defective bone with healthy bone or bone substitute is a critical problem in orthopedic treatment. Recent advances in tissue engineering have shown promising results in developing bone material capable of substituting the conventional autogenic or allogenic bone transplants. In the present review, we have discussed natural and synthetic scaffold materials such as metal and metal alloys, ceramics, polymers, etc. which are widely being used along with their cellular counterparts such as stem cells in bone tissue engineering with their pros and cons.
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