Ann Dermatol.  1996 Oct;8(4):250-252. 10.5021/ad.1996.8.4.250.

Erythema Multiforme due to Diphenylcyclopropenone

Abstract

A 34-year-old man visited our hospital with alopecia areata on the occipital scalp, which began to develop two months prior to his visit. He was sensitized with 0.2% diphenylcyclopropenone(DPCP) in acetone that was applied to the inner side of his right arm. Two weeks after sensitization, we applied DPCP on his bald lesion once weekly for skin challenge. Following the third application of DPCP, polycyclic erythematous target-like lesions developed around the sensitized area. A clinical diagnosis of erythema multiforme was made. Histologically, the target-like lesion showed few eosinophilic dyskeratosis, exocytosis, and hydropic de-generation of basal layer in the epidermis, and mononuclear infiltration around superficial blood vessels in the dermis. We report herein a rare case of erythema multiforme following topical application of DPCP in the treatment of alopecia areata. This complication must be noted because of the wide-spread and frequent use of DPCP in dermatotherapeutic fields.

Keyword

Diphenylcyclopropenone(DPCP); Erythema multiforme

MeSH Terms

Acetone
Adult
Alopecia Areata
Arm
Blood Vessels
Dermis
Diagnosis
Eosinophils
Epidermis
Erythema Multiforme*
Erythema*
Exocytosis
Humans
Scalp
Skin
Acetone
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