J Korean Neurol Assoc.
2003 Apr;21(2):174-182.
Neuroprotective Effect of Genistein Against beta Amyloid-Induced Neurotoxicity
- Affiliations
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- 1Department of Neurology, Ajou University, School of Medicine, 5 San Woncheon-dong, Paldal-gu, Suwon-si, 442-749, Korea. nmboy@unitel.co.kr
- 2Brain Disease Research Center, Ajou University, School of Medicine, Korea.
Abstract
- BACKGROUND
Estrogen is beneficial to patients with Alzheimer's disease but has a limited clinical use due to its proliferative and oncogenic effects on non-neuronal estrogen responsive cells. METHODS: In an attempt to find an estrogen substitute that retains the beneficial effects of estrogen with minimal side effects, we compared the neuroprotective and proliferative effects of genistein, a selective estrogen receptor betaagonist, with those of estrogen. RESULTS: Genistein and 17beta-estradiol showed comparable levels of protection against Abeta-induced death of cultured SH-SY5Y human neuroblastoma cells, which was blocked by an estrogen receptor antagonist, ICI 182, 780. On the other hand, 17beta-estradiol, but not geninstein, induced proliferation of uterine endometrial cells. CONCLUSIONS: Our results suggest genistein as a potential alternative to estrogen in the treatment of Alzheimer's disease.
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