J Korean Soc Endocrinol.  1998 Sep;13(3):495-500.

Impaired Glucose Tolerance Associated with Klinefalter Syndrome

Abstract

Klinefelter syndrome is one of the most common forms of primary hypogonadism and infertility in males. It is a clinical syndrome consisting of gynecomastia, azoospermia, and increased urinary excretion of follicle-stimulating hormone. Fequency of diabetes mellitus, emphysema, asthma, breast cancer increase in Klinefelter syndrome. We report a 16-year-old male patient with impaired glucose tolerance in association with Klinefelter syndrome, which was confirmed by chromosome analysis. The mechanism of impaired glucose tolerance in this patient was peripheral insulin resistance which clarified by euglycemic hyperinsulinemic clamp test.


MeSH Terms

Adolescent
Asthma
Azoospermia
Breast Neoplasms
Diabetes Mellitus
Emphysema
Follicle Stimulating Hormone
Glucose*
Gynecomastia
Humans
Hypogonadism
Infertility
Insulin Resistance
Klinefelter Syndrome
Male
Follicle Stimulating Hormone
Glucose
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